Benzos Sublingual Clonazepam and cimetidine? Pontentiation?

[vin]

One simple question, that I haven't found a clear answer too. I usually take 600-800 mg of cimitedine about 2 hours before taking my morning clonazepam and it does really prolongue it's actions (doesn't really make it much stronger though).

Unless my stomach is empty clonazepam doesn't even work at all and I resort to sublingual. Will the cimitedine still potentiate the klonopin even if it's taken sublingually?

 

[dirzted]

Yes, potentiation (involving the inhibition of enzymes anyway) is still effective regardless if the drug enters the body via the stomach.

 

[tricomb]

I like your username.

Clonazepam can't be forced into acting any better than it does taken by itself, I've never had anything potentiate any of the benzodiazepines I've taken and I've taken probably 95% of the benzodiazepines used in modern medicine, may I ask, just what does the cimetidine do? Like for you individually, I know what some other people have reported from attempting to potentiate a benzodiazepine although the consensus by a landslide report that nothing they've tried does anything whatsoever, and that the only way to get more out of a benzodiazepine is to take a slightly higher dose of the benzodiazepine you're trying to potentiate. In conclusion, the only way that I, and most of the people I've discussed this subject with, overall seem to feel that it may be best not to mess around with enzyme inhibitors if there's no point in doing so.

I mean maybe something may extend a half life by a negligible to minor-moderate amounts, so maybe it stays in your system a tiny bit longer, but do you actually feel a significant difference from taking benzodiazepines (especially other than clonazepam, have you taken other benzodiazepines? Clonazepam is a poor example because of it's notoriously annoying onset which takes hours, whereas most benzodiazepines are meant to kick in quickly, plus it's wildcard of a half life, so I'm just asking in general with benzodiazepines...) with potentiating them.

How is it effective or desirable over just taking the clonazepam by itself?

Is cimetidine the only chemical you've used? Clonazepam takes so freaking long to kick in already, no matter what ROA be it IV, sublingual, or oral administration, it still takes the same amount of time for onset to kick in and for it to peak in hours, so what if potentiating with clonazepam actually made it take even longer for your body to feel the clonazepam kick in?

Just curious.

 

[adder]

Theoretically the enzyme inhibition by cimetidine in this case would slow down the metabolism of clonazepam into its 7-amino metabolite. I don't know to what extent and whether it would give any noticeable effects. The said metabolite is active on its own, but to a lesser extent.

Honestly, I don't really think that it's possible to feel that your clonazepam works longer when you take it on a daily basis. I was on clonazepam for 6 years straight and in my experience taking it every day it's very hard to feel when it stops working. When I ran out of it at times, it would take 2-3 days for me to start withdrawing (around a week to completely immobilize me so I couldn't go out and find some). I think it's all in your head and that's the reason why you can't feel it taken orally. It does start working faster taken sublingually and it's more possible to feel some sort of a hit (not a rush, just a little bit stronger feeling at the very beginning, very short-lived) that way than p.o., but that's only when your tolerance isn't high yet.

 

[tricomb]

Yeah I've never felt anything from taking clonazepam ever at any time, after taking it routinely for an extended time period and using it once in a while like if for whatever reason I'm in the very unlikely situation where I need a benzodiazepine and I don't have any of my own and clonazepam is the only option, I will take it but never feel any better. But I figure it'd be better to take it than to not in those situations like say, a stimulant OD not hospitalization-worthy but still technically speaking, the term overdose doesn't mean that the patient will die if not admitted to a hospital, like if I accidentally take an extra tablet of diazepam, technically I overdosed, but it's so mild I won't even notice that I took more than I thought I had.


Clonazepam is supposed to have a high affinity for the anti-convulsant subreceptor though so situations where the seizure threshold is diminished, meaning not just in stimulant ODs, but you know some people insist on trying to abuse tramadol, regularly, and take anti-convulsants because the drug lowers seizure threshold. Alcohol also lowers seizure threshold (after raising it temporarily).