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Sublingual Alprazolam?

actually there is a sublingual (meant to dissolve under the tongue) alprozolam. i think the ones i had were 1 mg. dissolves in a sec. seemed to work quicker than eating them. wish i had more. ;)
 
ttfunk said:
actually there is a sublingual (meant to dissolve under the tongue) alprozolam. i think the ones i had were 1 mg. dissolves in a sec. seemed to work quicker than eating them. wish i had more. ;)
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It's called NIRAVAM. Well Niravam is "Orally disentegrating Alprazolam tablets"
 
What the hell is with everyone saying alprazolam tastes bad? It doesn't taste bad at all. Maybe a little chalky, but it has very little taste in comparison with other pills/stuff.
 
biggerstronger said:
What the hell is with everyone saying alprazolam tastes bad? It doesn't taste bad at all. Maybe a little chalky, but it has very little taste in comparison with other pills/stuff.
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actually i'm pretty sure alrprazolam itself has a fairly strong bitter taste. some brands do such a good job disguising it with fillers/binders/whatever that their pills just taste chalky with a hint of bitterness.
 
The bioavailability is equivalent.

Thirteen healthy volunteers received 1 mg of alprazolam, as the commercially available oral tablet, by sublingual and oral routes on two occasions in random sequence. Plasma alprazolam concentrations during 48 hours after each dose were measured by electron-capture gas-liquid chromatography. The peak plasma concentration after sublingual dosage was higher than after oral administration (17.3 vs. 14.9 ng/ml), and the time of peak concentration following sublingual administration was reached (1.17 vs. 1.73 hours after dose). However, these differences did not reach statistical significance. The mean total area under the plasma concentration curve for sublingual administration was slightly but not significantly larger than that following oral dosage (203.7 vs. 194.4 hr.ng/ml) and no significant differences between sublingual and oral dosage were found for elimination half-life (11.7 vs. 11.8 hours) or for clearance (86.4 vs. 92.4 ml/min). Thus, alprazolam absorption following sublingual administration is as rapid as after oral dosage on an empty stomach, and completeness of absorption is comparable. In clinical terms, sublingual and oral dosages of alprazolam are likely to be therapeutically equivalent. The sublingual route may be a useful alternative for panic disorder patients who cannot swallow pills or for those who do not have access to a liquid at the time of dosing.
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Source
 
As soon as I posted on the GBL thread saying how I could only sleep talking alprazolam, I took two mgs sub-lingual and read this thread. I find alprazolam to kick in faster sub-lingual. I actually use this ruote when I have had dinner, find that I cannot fall asleep and take the alprazolam. Stomach content seems to affect widely onset of drug, where as sub-lingual seems to avoid the stomach route hence kicking faster.
 
It's a taste I never got used to either. Yuck.


I'd do SL instead of oral if I had a full stomach... Otherwise oral is fine, maybe parachuted if I was really concerned with onset.
 
I'm currently taking 6 x 50mcg SL having just handed in an essay. I handed the essay in 1 minute late so wil probably have the mark capped at 50% so i'm pretty fucked off right now, and from experience I know this should work. I often take then SL, just a habit as taking 8mg Subutex, and often taking k-pins that way. Taste isn't too BAD, its not like zopiclone or anything!!!
In fact, in the time its taken me to write this post I'm feeling that alprazolam creeping up my back!!

Time to get drunk I think!!

AN
 
burn out said:
it's an acquired taste.
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right right
but the sublingual has a pleasant taste (good old pharma. companies, taking care of business)!
i was trying to think of who that would be medically appropriate for and assumed someone who had a hard time swallowing might prefer that to the pill....
i loved it but never had a script, just got some from a friend.
 
It seems as if taking an alprazolam tablet meant for oral consumption sublingually wouldn't be worth it, but if you had alprazolam powder or pills designed specifically for sublingual administration you could get an even quicker onset and possibly a slightly higher peak.
 
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