JackiesBabyy
Bluelighter
- Joined
- May 16, 2011
- Messages
- 595
How would this compare to oral/insufflation?
(I'm talking about IR pills, obviously)
(I'm talking about IR pills, obviously)
Sublingual adderall.
- Thread starter JackiesBabyy
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NeighborhoodThreat
Bluelight Crew
Probably around the same time frame as insufflation, maybe a bit longer. Of course, it has the benefit of not tearing up your sinuses.
It will be noticeably faster than oral for sure. When I take amphetamines, sometimes I'll sublingually take half the dose and orally take the other half. Works quite well.
It will be noticeably faster than oral for sure. When I take amphetamines, sometimes I'll sublingually take half the dose and orally take the other half. Works quite well.
morphonorconic
Bluelighter
I prefer to take adderall sublingually. Kicks in very quickly but lacks the edginess you sometimes experience with insufflation. I'd recommend it to a friend.
SerotonergicHaze
Bluelighter
I took dexedrine sublingually once and it was a bit of a disappointment. I think just oral + antacid is better. If you really want to make it kick, take around 70mg DXM about an hour or two before dosing. I'm not sure how safe the combination is since DXM is an NRI and SRI, but the latter is not particularly germane to amphetamines. 70mg DXM + 25mg Dex usually was pretty euphoric
ErgicMergic
Bluelighter
Sublingual d-amp is no big deal, just a quicker onset bypassing first pass metabolism. However, sublingual L-amp (in Adderall) apparently has a higher sublingual BA from what I've read on BL, and ime it kicks in extremely fast, making even 3.75mg Adderall (1/8 of 30mg IR) very noticeable, almost too intense on the PNS, even causing bellringers with the intense vasoconstriction. It almost kicks in instantly, it's pretty ridiculously intense, this is why chewing Adderall is so effective vs. chewing Dexedrine.
Adderall's a helluva drug, and it gets in to too many of the wrong teenage hands. Dexedrine should be commonplace in the US, imo, less abuse potential at therapeutic dosages, less side effects, and with less of a "tweak" or edginess than can be chased through insufflation or sublingual administration. Adderall makes me feel like I'm on something, while Dex simply makes me more alert and focused without making me feel like I'm on drugs.
70mg DXM with 25mg D-amp is safe, SH, since d-amp does not have appreciable NE or 5-HT activity, unlike l-amp (adderall), which has potent NE activity.
Adderall's a helluva drug, and it gets in to too many of the wrong teenage hands. Dexedrine should be commonplace in the US, imo, less abuse potential at therapeutic dosages, less side effects, and with less of a "tweak" or edginess than can be chased through insufflation or sublingual administration. Adderall makes me feel like I'm on something, while Dex simply makes me more alert and focused without making me feel like I'm on drugs.
70mg DXM with 25mg D-amp is safe, SH, since d-amp does not have appreciable NE or 5-HT activity, unlike l-amp (adderall), which has potent NE activity.
SerotonergicHaze
Bluelighter
Dexamphetamine has strong NE activity. However compared with other stimulants, it is lower relative to dopamine activity.
The difference with dexamphetamine is that it does not have a huge preference for NET. So a dose adequate enough to produce a fun level of DAT binding, still results in some NET binding. However, a drug that prefers NET, would result in heaps of NET binding in order to get the same fun level of DAT binding. A large or even moderate dose of dex, would cause quite significant norepinephrine release,
I'm being pedantic, but still.
In regards to why Dexedrine is not used as much as Adderall. I think it's because Dexedrine lacks the 'kick', I find myself sleepy even after 30mg worth. The kick of adderall is helpful in treating the sleepy, daydreamy kind of ADD, but the issue is I think it kicks too hard. Perhaps the pharm companies could try 85% Dextro, 15% Levo, or even 60% D-amp, 30% D-methamp, 10% l-amp. The meth would make it more mellow but still very focusing, and the small L-amp would give it a slight kick to get you out of bed
The difference with dexamphetamine is that it does not have a huge preference for NET. So a dose adequate enough to produce a fun level of DAT binding, still results in some NET binding. However, a drug that prefers NET, would result in heaps of NET binding in order to get the same fun level of DAT binding. A large or even moderate dose of dex, would cause quite significant norepinephrine release,
I'm being pedantic, but still.
In regards to why Dexedrine is not used as much as Adderall. I think it's because Dexedrine lacks the 'kick', I find myself sleepy even after 30mg worth. The kick of adderall is helpful in treating the sleepy, daydreamy kind of ADD, but the issue is I think it kicks too hard. Perhaps the pharm companies could try 85% Dextro, 15% Levo, or even 60% D-amp, 30% D-methamp, 10% l-amp. The meth would make it more mellow but still very focusing, and the small L-amp would give it a slight kick to get you out of bed
ErgicMergic
Bluelighter
SH, from what I understand, d-amp only has a 1:1, DA:NE, release, and when you consider the subjective potency of DA to NE, a normally used ADD dosage of Dexedrine has very little NE release that we can feel. I have inattentive ADD, and nod quite often on Dexedrine, I need to use caffeine or ephedrine or another PNS stimulant in low dosages to counteract that.
That "kick" from the Adderall has all sorts of side effects, though. L-amp is so powerful and nasty that it actually changes your personality when you're on it, you might not notice it but your friends and family certainly do. It induces much more of the autonomous, robot WORK!WORK!WORK! ethic, which can be tiring and annoying when you're not working. It also flattens your emotions and blunts your creativity, I have no idea how L-amp is so powerful compared to Ephedrine, chemically, maybe better BBB crossing and more CNS NE release? And these are at low dosages, I've never taken more than 7.5-10mg of Adderall IR at a time, I take no more than 5-7.5mg of Dex IR at a time.
What I do, like you mentioned, is actually make my own combos. I mix Dexedrine to Adderall at a 2:1 or 3:1 ratio, which is basically what you mention, during the rare times I can actually get my hands on Addies. I usually take Dexedrine to Caffeine at a 1:5-1:7 ratio, or Dex:Ephedrine at a 1:1 ratio. I agree that the Adderall has too much kick, and think that replacing L-amp with Ephedrine at a 1:10 replacement ratio would actually be a better choice for a new Adderall formulation, as L-amp is so potent and nasty. The only problem is that it would look so stupid to pick up your generic "Dextroamphetamine sulfate, Ephedrine HCL" at the pharmacy. Soccer moms would gather in legions to decry putting "asthma medications!!! omg!!!" in to little Johnny's Adderall. 8)
That "kick" from the Adderall has all sorts of side effects, though. L-amp is so powerful and nasty that it actually changes your personality when you're on it, you might not notice it but your friends and family certainly do. It induces much more of the autonomous, robot WORK!WORK!WORK! ethic, which can be tiring and annoying when you're not working. It also flattens your emotions and blunts your creativity, I have no idea how L-amp is so powerful compared to Ephedrine, chemically, maybe better BBB crossing and more CNS NE release? And these are at low dosages, I've never taken more than 7.5-10mg of Adderall IR at a time, I take no more than 5-7.5mg of Dex IR at a time.
What I do, like you mentioned, is actually make my own combos. I mix Dexedrine to Adderall at a 2:1 or 3:1 ratio, which is basically what you mention, during the rare times I can actually get my hands on Addies. I usually take Dexedrine to Caffeine at a 1:5-1:7 ratio, or Dex:Ephedrine at a 1:1 ratio. I agree that the Adderall has too much kick, and think that replacing L-amp with Ephedrine at a 1:10 replacement ratio would actually be a better choice for a new Adderall formulation, as L-amp is so potent and nasty. The only problem is that it would look so stupid to pick up your generic "Dextroamphetamine sulfate, Ephedrine HCL" at the pharmacy. Soccer moms would gather in legions to decry putting "asthma medications!!! omg!!!" in to little Johnny's Adderall. 8)