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Bupe strange occurence...

H

hydrobliss

Bluelighter
Joined
Jun 5, 2010
Messages
260
Location
USA
I know that if you are taking opiates and you use bupe it is supposed to send you directly into withdrawal. BUT I can counter this by the expiriment I just did...

I just slammed 100MGs of Oxy.... then slammed (injected) 8MG of Bupe 1 hour later
I am higher than ever.... why?
 
It's not the bupe that causes the immediate WD symptoms. It's the naloxone found in suboxone. Straight bupe is an potent opiate just like fentanyl.
 
I just know some moderator is hoping someone will say this for them... Actually, it is the bupe that causes the precipitated w/d syndrom despite the fact that bupe is a potent opiate. It is also a partial antagonist. Naloxone doesn't do what it's supposed to do, as you can inject a suboxone tablet without going into w/d. But I find that injecting suboxone is not worth it, while subutex totally is.
 
Also I can inject bupe an hour after oxy without a problem at all, because I am dependent on buprenophine, not oxycodone. If I took oxy every day and then did that, there would be a risk of going into precip. w/d, however, since I bupe is what my receptors are used to, when it displaces oxy it won't make me sick, understand?
 
I think I get it. Thats why you can take pain pills while on bupe right? But if your receptors are full of suboxon your waiting your pain pills correct?
 
Bupe will attenuate other opiates in high enough doses. Whether taken before, or after. At large doses bupe acts as an antagonist in the presence of full agonist opiates. At small doses bupe continues to act as an agonist, and its effect is additive.

As far as precip WD, generally you are only going to get them if you would be going into withdrawal if you hadn't dosed the full agonist. If you aren't already fully dependent, but still tolerant, to OC you may not go into precip WD. The more full agonist you have dosed with prior to dosing the bupe the more likely it is to occur.
 
That's interesting. Very interesting.

I mean, if your IV'ing 100mg oxy or 8mg bupe in the first place, your very tolerant. And I don't think it's possible to be that tolerant without also being addicted. Granted, your addiciton may not be as bad as say, mine, because your "regular" dose is lower than 100mg oxy, meaning 100mg oxy gets you high. But 8mg suboxone IV is a shitload. it literally takes 24-40mg sublingual bupe to equal 8mg IV. So huge habit or not, it should have theoretically sent you into DT's. However, as Dhopeless stated, if you already take suboxone regularly, your receptors would be accustomed, and so it would be no problem.

Personally, I have only seen one person go into precipitated WD from bupe, and it went away a few minutes later because they injected more. It is very hard to go into DT's from bupe. You have to have a large addiction to full-agonists, and have to do bupe while your receptors are fully saturated. Remember, IV oxy only lasts an hour or 2 anyway.

So basically, by tje time you did it, half of the oxy IV was already out of your system, and so the bupe filling the receptors didn't cause DT's, since it's partial agonist activity is actually stronger than a small dose of IV oxy. You not having a large addiction plays a part, since obviously, however much you use on a daily basis, 8mg of bupe covers it, without shocking your system. In fact, it even got you high!!!

So no surprise really. People are just scared of bupe for no reason, even though I have banged oxy and dosed bupe shortly afterwards many times(I wait longer than an hour, but still)

(Edit to note that, again, 8mg IV bupe is A LOT. In fact it would take a good tolerance not to get sick...)
 
He definitely has a high tolerance, but it could have been many days since the last time he used a full agonist.

And lorne is right, at least my experience agrees with him, it is pretty hard to precipitate WDs from bupe. But anyone who has ever been shot with narcan, or taken a naltrexone before detoxing knows how bad they can be. But naltrexone and narcan act as inverse agonists in the presence of full agonists, and antagonists without them. So they obviously cause PWD MUCH more easily.
 
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