Hello I started my heroin detox using subutex but I'm still having unbearable diarrhea. I looked around the forum and online to try find out just how much imodium ad I can take without throwing my subutex out of whack. Is it safe to take a regular dose of 30mg or should I take a smaller dose?
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OD Moderators: Keif’ Richards | negrogesic
Bupe Started my heroin detox using subutex. Need immediate help with Imodium AD dosage!!!
- Thread starter blckhwk
- Start date
Mr.Scagnattie
Bluelighter
Where did you get that a regular dose is 30mg's...? The recommended dose for treating the symptoms of diarrhea is like 4mg's.. If you're already on bupe, you do not need to be munching 30mg's of loperamide.
Do you normally take 30mg of loperamide? 
I'm not sure of the difference in affinity strength for the µ-receptors in the GI tract between buprenorphine and loperamide, but loperamide's is high enough I think it should work to some degree. Whatever dose of loperamide you normally use during detox and see how that plays out.
I'm not sure of the difference in affinity strength for the µ-receptors in the GI tract between buprenorphine and loperamide, but loperamide's is high enough I think it should work to some degree. Whatever dose of loperamide you normally use during detox and see how that plays out.
It's 16mg per 30mL (6 teaspoons/3 table spoons).
In pill form it comes in 2mg tablets, and for opioid detox, I would normally work around 8-12mg/day taken in one dose. This will probably constipate you just as bad as the opioids did, but I was fine with that as I didn't feel like sitting in the bathroom while going through acute withdrawals. I didn't like doing anything during this period, but sitting on the toilet was definitely at the top of my "shit list" (pun intended
).
In pill form it comes in 2mg tablets, and for opioid detox, I would normally work around 8-12mg/day taken in one dose. This will probably constipate you just as bad as the opioids did, but I was fine with that as I didn't feel like sitting in the bathroom while going through acute withdrawals. I didn't like doing anything during this period, but sitting on the toilet was definitely at the top of my "shit list" (pun intended
).
sekio
Bluelight Crew
Buprenorphine has a higher affinity for opioid receptors than loperamide does, I don't know if it will do much at all if you are using bupe as well. You can try it and see, of course, but if it doesn't help don't push the dose up. People have died from being reckless with loperamide especially in combination with other drugs.
Loperamide exhibited potent affinity and selectivity for the cloned micro (Ki = 3 nM) compared with the delta (Ki = 48 nM) and kappa (Ki = 1156 nM) [...]
http://www.ncbi.nlm.nih.gov/pubmed/10087042
Published data clearly shows the Ki or binding affinity of buprenorphine is 0.2157 nM, while that for naloxone is 1.1518 nM. [...]
http://www.ncbi.nlm.nih.gov/pubmed/21215785
Because buprenorphine has a lower affinity it binds tighter to opioid receptors and will displace loperamide from them. As such I'd expect it to be more effective when you haven't taken a Suboxone dose recently.
Also, because in the end loperamide is just an opioid that acts peripherally, it will prolong the physical nastiness of withdrawals (gut issues and other physical malaise) if you use it at a high dose or for too long. Use it as sparingly as you can because you'll end up burning yourself if you go on prolonged courses of Immodium...
Loperamide exhibited potent affinity and selectivity for the cloned micro (Ki = 3 nM) compared with the delta (Ki = 48 nM) and kappa (Ki = 1156 nM) [...]
http://www.ncbi.nlm.nih.gov/pubmed/10087042
Published data clearly shows the Ki or binding affinity of buprenorphine is 0.2157 nM, while that for naloxone is 1.1518 nM. [...]
http://www.ncbi.nlm.nih.gov/pubmed/21215785
Because buprenorphine has a lower affinity it binds tighter to opioid receptors and will displace loperamide from them. As such I'd expect it to be more effective when you haven't taken a Suboxone dose recently.
Also, because in the end loperamide is just an opioid that acts peripherally, it will prolong the physical nastiness of withdrawals (gut issues and other physical malaise) if you use it at a high dose or for too long. Use it as sparingly as you can because you'll end up burning yourself if you go on prolonged courses of Immodium...
Experience has taught me that Stool Sofners , under a good generic Name is better than any Imodium, However your under the idea that since quitting H is going to have you running to the Bathroom. Not the case if you were completely honest with needed amount of Sobuxin. As with Sobuxin, it will still be constipating may (not much) a little different then your treatment dose!
Hope that helps in some way!
Hope that helps in some way!