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SSRI + Racetam + Ecstasy

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LeetG

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Oct 8, 2010
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Anyone have experience with this combo?


Currently on 10mg lexapro and want to go raving. Already reduced frequency of lexapro to every second day, eventually planning to be off it for a week before popping (test phase), if that doesn't work, I will take another two weeks off (rave phase).
 
My wife takes the same meds and dosage as you. She takes it every day and felt the effects of MDMA last time we rolled. Although she had a blast, we both agreed that her response was slightly blunted from her SSRI usage.

We are rolling tonight and both trying a 3200mg attack dose of piracetam about 2-3 hours before we drop. I will post back and let you know if she perceives her high to be more intense or different at all. This is something I've been really curious about myself because of all the great things I've heard about piracetam.
 
I'm not sure if piracetam is going to magically just stop what an SSRI does to your brain..
piracetam is a wonderful smart drug, but for people NOT on SSRIs.
If you are going to do MDMA while OFF an SSRI, it's best to wait at least a month to flush it out of your system completely.
But if you are on an SSRI, it's not really a good choice to get off of it.. just to roll. which can create even more depression..
 
This is an interesting topic that I haven't really seen answered.

I was doing some research on the combination of piracetam and SSRI's without MDMA as I couldn't find too much concerning the 3 together.

There is a post here on bluelight with 1 person's reactions to SSRI's and Piracetam.

Meat Bag said:
I've tried combination of paroxetine (don't remember exact dose, one tablet) and piracetam (800mg.), and I can say it was one horrible experience! Terrible anxiety, hands shaking, nausea, change of color perception. For first 1-2 hours after effects kicked in I was quite agitated, but then agitation droped off (but no anxiety though), after that I fall in very disturbed sleep for the next 16 hours or so. Effects were fully dropped of only next evening.
But I'm not prescribed to paroxetine or any other SSRI.
Two weeks after, my friend, who was prescribed to it due to her depressive state (for two-three months) tried to combine her standard dose with 800mg. of piracetam, and she was experienced exactly same effects with less anxiety reaction.
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Source: http://www.bluelight.ru/vb/showthread.php?p=6543279


Another user on another forum stated that his use of Piracetam carried no bad side effects with the combination of any SSRI.

No interaction between piracetam and fluoxetine (or any other SSRI).
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Source: http://www.imminst.org/forum/topic/44678-piracetam-and-fluoxetine-prozac/
Source: http://www.imminst.org/forum/topic/36727-combining-piracetam-with-an-ssri/


Most sites suggest that it isn't a dangerous combination - but I haven't come across any strong, concrete evidence suggesting it's completely safe. I think it's safe to say that it won't kill you, but I cannot speak for other risks. Keep in mind the Piracetam is a very safe chemical, but SSRI's on the otherhand aren't so much.
 
My wife is on 10mg lexipro daily. We tested her interaction with piracetam by itself and she stated she felt much more clear headed but it was a really week effect. Last time, her first, she took 2 capsules of Molly separated by about an hour and a half. She had heightened sensation and energy but no empathy. This weekend was her second time. She preloaded with 3200mg piracetam two hours before she took her first capsule. Total dosage this time was 2.5 capsules. One then another after one hour and then another half an hour after that. She had a much more intense roll, was loved up and feeling the empathy... Was really blown away because she didn't expect it.

This does t have to be because of the piracetam, it could just be from a slightly increased dose. We will be using it from now on, the antioxidant effect is enough alone.
 
Mesial glad to hear that about your wife. Was piracatam mixed with lexapro, or did she discontinue usage of lexapro prior to the roll?

With the results of your wife, this looks promising as I always theorized racetams would have an effect. I will try a racatam combo in two couple of weeks and post results here. Currently have piracetam, but have oxiracetam and aniracetam in the mail.
 
LeetG said:
Mesial glad to hear that about your wife. Was piracatam mixed with lexapro, or did she discontinue usage of lexapro prior to the roll?

With the results of your wife, this looks promising as I always theorized racetams would have an effect. I will try a racatam combo in two couple of weeks and post results here. Currently have piracetam, but have oxiracetam and aniracetam in the mail.
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She kept taking her lexipro, just like everyone else who is taking an antidepressant should do. She is on the medicine for anxiety, not for depression but stopping drugs to roll is not a good excuse. You should talk with your doctor before ceasing use of your medicine.

She took her lexipro when she woke up, and we rolled around 730pm. Mind you I do not feel piracetam affected my roll at all however. It's been two days since and I feel great but we had some really clean capsules.

Please let us know if you have any success yourself. Like I said before it may not have been the piracetam; we were in a drastically different setting and dose was increased by half a pill.

We are going to try the combination again in the end of January for our next roll. Can't wait!
 
Dsargkf said:
This is an interesting topic that I haven't really seen answered.

I was doing some research on the combination of piracetam and SSRI's without MDMA as I couldn't find too much concerning the 3 together.

There is a post here on bluelight with 1 person's reactions to SSRI's and Piracetam.



Source: http://www.bluelight.ru/vb/showthread.php?p=6543279


Another user on another forum stated that his use of Piracetam carried no bad side effects with the combination of any SSRI.



Source: http://www.imminst.org/forum/topic/44678-piracetam-and-fluoxetine-prozac/
Source: http://www.imminst.org/forum/topic/36727-combining-piracetam-with-an-ssri/


Most sites suggest that it isn't a dangerous combination - but I haven't come across any strong, concrete evidence suggesting it's completely safe. I think it's safe to say that it won't kill you, but I cannot speak for other risks. Keep in mind the Piracetam is a very safe chemical, but SSRI's on the otherhand aren't so much.
Click to expand...

Best response to the subject. There shouldn't be risks, but piracetam isn't going to magically negate the effects of the SSRI.
 
mesial said:
We tested her interaction with piracetam by itself and she stated she felt much more clear headed but it was a really week effect.
Click to expand...

I'm going to assume this was a short term attack dose (2400-3200mg). I have heard that it takes a little while for piracetam's full cognitive effects to kick in so I would be interested in the outcome of a long term experience with this combination.

As you said it took her around 2.5 caps to feel profound empathy - it brings the question if the dosage would have given those effects without the addition of piracetam as she is on a low dose of an SSRI. I have experienced people feeling the effects of MDMA (empathy included) from a higher dose of MDMA while they were on an SSRI (although I wouldn't suggest attempting such as it can lead to horrible side effects such as serotonin syndrome).


AylaV said:
Best response to the subject.
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Thank you :)


On another note, I discovered a study done on mice that shows that piracetam increases tryptophan levels in older subjects.

After piracetam administration, old mice showed a notably greater increase of their brain tryptophan than young animals. Furthermore, piracetam significantly improves the learning capacity of young mice, but the drug is remarkably more active in improving the performance by old mice.
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Source: http://www.ncbi.nlm.nih.gov/pubmed/6165698


Could this mean that piracetam increases the amount of serotonin levels within humans as that would account for the potentiation of MDMA? I'm not a doctor nor do I have any medical background, but this intrigues me.

Opinions?
 
We only use attack doses since there is a large number of posts on BL that indicate that this is the best option when trying to increase the effect of certain drugs. If we were studying for exams or needed to have a clear mind to prepare for something in the future I would try piracetam daily but this just is t of interest to me right now.

As for her feeling the empathy, the piracetam could have helped but I also know that dosage of MDMA could do it. I'm 280lbs and I felt nothing but sweaty palms when I took 1.5 of our clean tested capsules. Took one more an hour later and I was ear to ear grinning. Took another half about 60 mins later. She took one and a half and definitely started rolling then one more around an 90mins later. I wouldn't consider that a large dose that could potentially cause serotonin syndrome. Plus, just like was mentioned, her ssri dosage is low.
 
mesial said:
We only use attack doses since there is a large number of posts on BL that indicate that this is the best option when trying to increase the effect of certain drugs. If we were studying for exams or needed to have a clear mind to prepare for something in the future I would try piracetam daily but this just is t of interest to me right now.
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I was referring to piracetam having a weak effect on her solely without the use of MDMA.

mesial said:
I'm 280lbs and I felt nothing but sweaty palms when I took 1.5 of our clean tested capsules.
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Interesting. Do you have a tolerance to MDMA? Also, are you aware of the dosages in each capsule? I would be surprised that if it was clean molly that 100mg would have no effects but sweaty palms. Brings be to believe that it may be adulterate or there's a tolerance issue.

mesial said:
I wouldn't consider that a large dose that could potentially cause serotonin syndrome. Plus, just like was mentioned, her ssri dosage is low.
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If each cap is around ~100mg, you've taken around 250mg. For you that may not be a larger issue because you may have a tolerance and previous exposure to the drug. Your wife on the other hand, I'm assuming hasn't rolled before due to her SSRI medications so we can say she has no tolerance. I'd say her consuming ~250mg her second time rolling is a fairly high dose (for her), especially with interaction with an SSRI. I understand she is on a low dose, but that doesn't remove the risks associated with this combination. I'm just trying to keep safety in mind :)
 
Totally see where you are coming from and I appreciate the comments. I have not read any exact numbers on how much MDMA has caused SS in those who have suffered from it. We will not be increasing the dose for her from this point. She is 160lbs and this was also her second time rolling. The only tolerance she has is due to the ssri she is taking. I'm pleased she can share the experience and I would certainly not want to push the limit. I have a hunch that although we had clean capsules that there was much less than 100mgs in each. I don't have a scale and I don't think it would matter due to unaccounted for filler. The capsules were half full.
 
mesial said:
Totally see where you are coming from and I appreciate the comments.
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You're quite welcome :) I have enjoyed this discussion very much and have managed to learn a few things out of it.

Unfortunately, I don't think exact numbers will ever exist as this greatly varies from person to person and medication to medication dosages. Each person may have a different effect, some more prone to serotonin syndrome than others. I would agree that an SSRI may technically require more MDMA to achieve effects, but this also raises the damage caused.

I'm not sure if frequent use of MDMA while on an SSRI is a good idea even though you may have had beneficial effects from the first (or second in this case) attempts to roll. I would be very careful with this combination, especially with long term usage.

mesial said:
The capsules were half full.
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I can't assume any weight based on this, but if it's a 0 sized capsule, that means it would likely contain upwards of 200-250mg of material if half full. I would also say that there is something else in there that may not be MDMA so it would be hard to judge how much is in each cap.
 
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