Speed Harm Minimisation?

[dailygrind]

Hi All,

There seems to be a hellofalot of info on minimising harm whilst using E, but little on minimising harm using speed.

Does anyone have any pointers on what to pre/post load with etc etc? Any other pointers?

Cheers,

DG

 

[wazza]

Anti-oxidants and l-tyrosine are generally the best.

try this link for a start.

 

[dailygrind]

Thanks wazza thats an excellent link, answered my questions.

-dg

 

[sixthseal.com]

Sodium bicarbonate

http://www.rxlist.com/cgi/generic/dextroamphetamine_ad.htm

rxlist.com states that dextroamphetamines are potentiated by alkalinizing agents like baking soda potentiates and prolongs the effects of amphetamines. Two paragraphs down, under MAOIs, it states that potentiating amphetamines increases the neurological toxic effects as well. Does this mean that using baking soda to potentiate amphetamines increases the neurotoxicity potential and thus should be avoided?

 

[phase_dancer]

Does this mean that using baking soda to potentiate amphetamines increases the neurotoxicity potential and thus should be avoided?

As a general rule; the longer toxic metabolites are present in plasma, the higher the toxicity.

Many drugs exist in the body as protonated and non protonated forms. The substance itself and it's metabolites have their elimination rates affected by pH and rates of protonation/ deprotonation (in this case sticking on or pulling off a hydrogen on an amine group). Baking soda will alter your urinary pH, making it more alkaline and lower rates of protonation.

Because of this, taking baking soda with MDMA or amphetamine will slow down elimination while maintaining high serum levels.

Too much baking soda at any time could cause alkalosis, a potentially life threatening condition. Moderate doses can be used to help with some urinary conditions, or to help eliminate an acid such as acetylsalicylic acid (aspirin)

 

[Paca]

Too much baking soda at any time could cause alkalosis

phase_dancer: any idea as to how much baking soda would actual cause this condition?. Are we talking alot of baking soda, say several hundred grams, or is it a reasonably small amount that can cause alkalosis?

 

[phase_dancer]

I'm not sure what would constitute too much, but we once did a prac in pharmacology where some of class ate 6 x 00 caps of baking soda. Apart from uncomfortable burping no other side effects were reported.

Goodman & Gillman's Pharmacology of Therapeutics 6th Ed. says 10-15 grams of bicarbonate are required to keep the urine persistantly alkaline for 24 hours. The mechanisms involved are many, however sodium retention affects this greatly. As amphetamines alter kidney function and in the case of MDMA, increase potential for edema, care needs to be exercised if you are thinking of using them with bicarb. I certainly wouldn't call the practice harm reduction.