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Someone Please, Effexor and GHB ?

T

ttocs

Ex-Bluelighter
Joined
Jan 6, 2006
Messages
358
Since I can't seem to get any responses in the OD forum about this combo. I figured I'd try here and hopefully somebody could shed some light. Anyway, in the past I've been fine with the combination of Paxil + GHB, and Lexapro + GHB with no negative effects or drug interactions.

I am wondering about the combination of EFFEXOR XR + GHB, since effexor is an SNRI, Seroontin and Norepenephrine Reuptake Inhibitor. I don't see how it would cause any problems. But if someone could please repond to me and help me out it would be greatly appreciated. I understand that while under an antidepressant medication that I should not be using recreational drugs at all. But I am going to keep my GHB usage limited ie: (weekends only). So if anyone has tryed this combo in the past or would know of any drug interactions, please let me know. Otherwise I don't see how it could be a problem since GHB does not effect either system. As far as I know, GHB only interacts with dopamine and GABA-B.

Anyone???:\

Thanks and much appreciated.
 
Nobody knows? I thought people on bluelight.ru were quite intelligent when it came to pharmacology. Effexor is different from Remeron, because Effexor is an SNRI, similar to Cymbalta. It's not a tetracyclic antidepressant, so there is no histamine release with effexor.

Bump this thread again I guess.
 
Your attitude isn't gonna help you get many responses thats for sure.

Anyway at high doses effexor starts to act as a dopamine reuptake inhibitor. Around 300mg's i think. How strongly it acts on it i dont know. What that means in terms of interacting with ghb i dont really know either.

Also i would imagine that the doses that effexor interacts with certain neurotransmitters varies from person to person.
 
paranoid android said:
Your attitude isn't gonna help you get many responses thats for sure.

Anyway at high doses effexor starts to act as a dopamine reuptake inhibitor. Around 300mg's i think. How strongly it acts on it i dont know. What that means in terms of interacting with ghb i dont really know either.

Also i would imagine that the doses that effexor interacts with certain neurotransmitters varies from person to person.
Click to expand...


Most people are not prescribed over 225mg's, so effexor is not really considered a dopamine reuptake inhibitor. My attitude was fine, I thought bluelight was the place to come for questions like this but I guess a lot of people on here are not qualified to speak about GHB or antidepressants.
 
http://www.bluelight.ru/vb/showthread.php?t=108959&highlight=Effexor+GHB

Venlafaxine:
Recreational Drug Interactions
Alcohol, GHB (and related substances), Benzos (Xanax, Valium, Klonopin etc), Opiates (Heroin, Codeine, Vicodin, Oxy etc), Barbituates, Ketamine: These drugs can be safely combined with venlafaxine, and there effects will not be significantly altered.

Hope that helps. Guess like anything if your unsure, start with a small dose.
 
I guess only people with the blackest of depressions go up in the 300mg dosage range for effexor. I dont even think it starts to affect norepinephrine until you get to around 225mg. So at the starting dose of 37.5mg its only going to be acting on serotonin.

I managed to get as far as 75mg a day i think. Then i just got sick of it.
 
I was put on effexor in 1994 before it was even approved I think. I'm fairly sure my shrink decided to throw me into a trial without even informing me. I started on 37.5 2x/day. I got increased heart rate and blood pressure, and some nausea and sleepiness. He quickly ramped me up to 75mg 4x/day within about 2 weeks, and the side effects got worse. I complained I was sleeping almost 20 hours a day, so his suggestion was "take all 4 pills at bedtime." I had a fun ambulance ride. Shortly after that I threw the bottle out and refused to let him prescribe me anything else.

To this day I still consider it one of the nastiest drugs I've ever run across. Considering GHB gave me a very similar bad reaction, I don't think mixing the two would be a good idea...
 
I take 300mg/day of Effexor XR, and my psychiatrist is thinking of uping it to 400mg, so a high dose isn't that uncommon.
 
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