chaseconroe
Bluelighter
me and my g/f are take a gram of shrooms each. Anything that i could take to enhance the trip even more?
shroom potentiator
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webbykevin
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Syrian rue seeds, 2 grams, crush them up and cap them and take 1/2 hour before the shrooms, take care with it though, it really kicks things up a couple of gears.
Also, don't eat anything for at least 6 hours before you take the shrooms, it will really help with any nausea and will potentiate the experience too.
Also, don't eat anything for at least 6 hours before you take the shrooms, it will really help with any nausea and will potentiate the experience too.
alteredstate8
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Datura can be very dangerous, before you think about ingesting any quantity of datura you should research it thoroughly. Syrian rue will potentiate it but there are certain foods you have to avoid because it is an MAOI.
sekio
Bluelight Crew
Cannabis is probably the most accessible drug to combine with mushrooms.
Syrian rue is also a potentiator of tryptamines and phenethylamines and can be used for this purpose. I don't reccomend using Datura alkaloids because they are really hard to dose. There can be significant variability among seeds.
Syrian rue is also a potentiator of tryptamines and phenethylamines and can be used for this purpose. I don't reccomend using Datura alkaloids because they are really hard to dose. There can be significant variability among seeds.
aguythatlikessmoke
Bluelighter
why potentiate it ??? just get more shrrooms. Start at 1 G and see how you feel! and if you don't feel to great after 90 Minutes take another half gram.
gingervitus
Bluelighter
Grapefruit! Grapefruit juice!
Avoid food the day you're planning on dropping them aside from maybe some grapefruit, there's a chemical in the fruit that helps to break down the drug or something like that -- that's just what I've heard at least. Not eating food the day means your body will work to eat up the mushrooms sooner and will be less likely to cause nausea as only mushrooms will be in your stomach.
Also, someone suggested pot. My first time on shrooms was a relatively low dose. We got our hands on some Sour Diesel though halfway through the trip though and that was when I started getting visuals. Some people don't like mixing bud with psychedelics as weed really makes things hazier -- less clear minded when normally a trip isn't too hazy. But that's up to you, I didn't notice any bad haziness or problems remembering the trip but hell the bathroom felt like a western movie and the car was made of Legos. It really helped out since we smoked it right when we were about to peak.
Avoid food the day you're planning on dropping them aside from maybe some grapefruit, there's a chemical in the fruit that helps to break down the drug or something like that -- that's just what I've heard at least. Not eating food the day means your body will work to eat up the mushrooms sooner and will be less likely to cause nausea as only mushrooms will be in your stomach.
Also, someone suggested pot. My first time on shrooms was a relatively low dose. We got our hands on some Sour Diesel though halfway through the trip though and that was when I started getting visuals. Some people don't like mixing bud with psychedelics as weed really makes things hazier -- less clear minded when normally a trip isn't too hazy. But that's up to you, I didn't notice any bad haziness or problems remembering the trip but hell the bathroom felt like a western movie and the car was made of Legos. It really helped out since we smoked it right when we were about to peak.
2c-goinsane
Bluelighter
more mushrooms, cannabis and nitrous are the easiest/most enjoyable ways for me to enhance a mushroom trip.
not eating for atleast 4 hours before you dose will help alot ime aswel(dont starve yourself thats not good either), also being on a healthy diet days before you ate them would be ideal aswel just my opinion though i know everyone does things differently.
like others said you could use mushrooms with syrian rue or b. caapi to enhance the experience, i would definitely research as much as you can about that before trying it imo. mixing a maoi with mushrooms will change the mushroom experience quite a bit. from what i have gathered make sure your pretty comfortable with eating mushrooms by themselves before you add a maoi in with them.
not eating for atleast 4 hours before you dose will help alot ime aswel(dont starve yourself thats not good either), also being on a healthy diet days before you ate them would be ideal aswel just my opinion though i know everyone does things differently.
like others said you could use mushrooms with syrian rue or b. caapi to enhance the experience, i would definitely research as much as you can about that before trying it imo. mixing a maoi with mushrooms will change the mushroom experience quite a bit. from what i have gathered make sure your pretty comfortable with eating mushrooms by themselves before you add a maoi in with them.
Thorns Have Roses
Bluelight Crew
There are chemicals in grapefruit juice that inhibit CYP3A4 (that's the most significant effect).
If you'd like more info on this, check out Inhibition of cytochrome P450 by furanocoumarins in grapefruit juice and herbal medicines by Lian Qing Guo and Yasushi Yamazoe.
Foreigner
Bluelighter
Grapefruit juice before the trip, weed after the peak.
Don't do datura. That shit fucks people up for life.
Don't do datura. That shit fucks people up for life.
Thorns Have Roses
Bluelight Crew
^You do realize it is possible to take it at sub-deliriant doses, right? I haven't combined it with a psych yet, nor done it at all in a while (it's really not good enough to do if you have anything else on hand), but I intend to try the former before the month is out hopefully. Until then I will not recommend the combo...especially not to someone who hasn't worked with datura before.
Really? I did not know that. I thought it would become stronger and more intense with a pharmaceutical MAOI just like Syrian Rue produces. I don't understand it either because inhibition of MAO would allow a bigger build-up of tryptamines, right? Or is there a difference in type (competitive vs. non-competitive or something). They're probably all reversible (the ones that are suitable), I heard that irreversible MAOIs would be unbelievably dangerous.
Do you have much experience with mushrooms, the both of you? Because Syrian Rue can cause very strong potentiation, I found it to be quite overwhelming and for a fair part in an unwanted way. Even though I was aware of this chance. If you do decide to take it, that suggested 2 grams is what I would also consider a maximum if I were you.
Grapefruit juice can potentiate via the 'lemon tek potentiation' way which is not really understood and properly proven like MAO inhibition is.
The mentioned CYP 3A4 (I really thought it inhibited the subtype 2D6 as well or instead but I just found out I was wrong) activity is a way of saying it does not work with mushrooms because the tryptamines are not broken down by those cytochromes / enzymes.
This kind of potentiation works by stopping/slowing/limiting the breakdown of a drug which logically allows for a higher build-up in concentration in the body and thus also stronger effect. The inhibitor should therefore slow the relevant and responsible enzyme and not some unrelated one.
For this reason grapefruit juice can make mushrooms stronger (through said lemon tek potentiation which is thought to be based on in vitro alkaloid conversion), but in a whole other way than how grapefruit juice can make opiates or DXM or a number of other things stronger (cytochrome P450 inhibition).
I think that the stronger a combined drug is on it's own, the less we should call it potentiation and the more we should call it synergy.
Other drug effects adding up in unrelated pharmacological mechanisms is not potentiating the mushroom's mechanisms.
Cannnabis for example, seems like synergy to me and it's not simply making the effects of mushrooms stronger but changing the resultant effect as well.
Ketamine: same thing.
Syrian Rue: does make the experience more spiritual and different (I'm not the only one who thinks so), but more of a potentiator especially considering the way it acts.
Moclobemide: apparently for DMT there is less 'change' in effect with oral ingestion compared to vaporizing DMT. So I'd have thought you could say it has little truly psychoactive effect on it's own or it 'colors' a drug experience less than Syrian Rue. But Sekio says differently when talking about mushrooms rather than DMT and of course I believe him.
Do you have much experience with mushrooms, the both of you? Because Syrian Rue can cause very strong potentiation, I found it to be quite overwhelming and for a fair part in an unwanted way. Even though I was aware of this chance. If you do decide to take it, that suggested 2 grams is what I would also consider a maximum if I were you.
Grapefruit juice can potentiate via the 'lemon tek potentiation' way which is not really understood and properly proven like MAO inhibition is.
The mentioned CYP 3A4 (I really thought it inhibited the subtype 2D6 as well or instead but I just found out I was wrong) activity is a way of saying it does not work with mushrooms because the tryptamines are not broken down by those cytochromes / enzymes.
This kind of potentiation works by stopping/slowing/limiting the breakdown of a drug which logically allows for a higher build-up in concentration in the body and thus also stronger effect. The inhibitor should therefore slow the relevant and responsible enzyme and not some unrelated one.
For this reason grapefruit juice can make mushrooms stronger (through said lemon tek potentiation which is thought to be based on in vitro alkaloid conversion), but in a whole other way than how grapefruit juice can make opiates or DXM or a number of other things stronger (cytochrome P450 inhibition).
I think that the stronger a combined drug is on it's own, the less we should call it potentiation and the more we should call it synergy.
Other drug effects adding up in unrelated pharmacological mechanisms is not potentiating the mushroom's mechanisms.
Cannnabis for example, seems like synergy to me and it's not simply making the effects of mushrooms stronger but changing the resultant effect as well.
Ketamine: same thing.
Syrian Rue: does make the experience more spiritual and different (I'm not the only one who thinks so), but more of a potentiator especially considering the way it acts.
Moclobemide: apparently for DMT there is less 'change' in effect with oral ingestion compared to vaporizing DMT. So I'd have thought you could say it has little truly psychoactive effect on it's own or it 'colors' a drug experience less than Syrian Rue. But Sekio says differently when talking about mushrooms rather than DMT and of course I believe him.
Foreigner
Bluelighter
Doesn't matter. After the horror stories I've read and heard from those closest to me, no way in hell would I ever dose with that.
Rorthron
Bluelighter
Datura is sometimes used in traditional Ayahuasca, so it's not unheard of. At the DMT-nexus some years ago there were several trustworthy reports that 3 Datura stramonium seeds are quite effective as potentiators without any noticeable deliriant effect. Also they seem to be quite useful in avoiding nausea in DMT beverages (atropine is an anticholinergic). I've never heard it being used with shrooms, though.
Yes but traditional ayahuasa is made by shamans who have pretty deep knowledge about these things. And if it turns out to be too much I bet they will explain the resulting delerious state as something spiritual that fits the story. Also the threshold for heavy effects can be different in such cultures. I read that one initiation rite for some tribe exists of a warrior-to-be person coming of age who has to wear a glove made of ants that have a particularly brutal sting. And they have to repeat this! So I'm guessing that a fucked up datura trip might be something that could be normal, and it is tried to guide or treat it in some way.
About the cannabis and mushroom combination: something I've heard others say and agree with myself is that during the peak and even plateau depending on dosage, smoking cannabis can make the trip too confusing. Even if it also makes it nicer regarding visuals. On the comedown however it is especially awesome to smoke. For habitual smokers the combination may be considerably more tolerable. I don't think I would recommend the combo for a beginning tripper but with 1 gram it could boost a trip that is otherwise just a little too weak to interesting levels.
About the cannabis and mushroom combination: something I've heard others say and agree with myself is that during the peak and even plateau depending on dosage, smoking cannabis can make the trip too confusing. Even if it also makes it nicer regarding visuals. On the comedown however it is especially awesome to smoke. For habitual smokers the combination may be considerably more tolerable. I don't think I would recommend the combo for a beginning tripper but with 1 gram it could boost a trip that is otherwise just a little too weak to interesting levels.
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webbykevin
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Some of them do, a vanishingly small number these days, In 1986 McKenna said if you go to the Amazon you are going to drink a lot of swill before you meet a Shaman skilled, caring and expert enough to look after you with a good quality brew and quality guidance, that was 25 years ago and real shamans were already thin on the ground at that time.
I imagine in these days of eco/spiritual tourism a lot of western wanna be shaman don't even get close to the the real magic.
Foreigner
Bluelighter
I respect different traditions but I will never change my mind about datura. Everyone I know who has done ayahuasca repeatedly with datura is fucked up for good, and the sad thing is that they don't even realize it. They aren't even aware of their own crazy talk.
Also, the dosage threshold between useful and bat-shit crazy with datura is very marginal. Unless you have 10 generations of ancestral knowledge to backup your procedure, or you're a fucking surgeon with dosing, I wouldn't.
We're talking about shrooms here. Add MAOIs if you must, or even grapefruit juice, but don't add datura on your own if you know shit all about it.
I don't care if other ppl think I'm a fear-mongering <snip>. Datura is the only drug that scares the living hell out of me, and I'm very experienced with etheogens.
Also, the dosage threshold between useful and bat-shit crazy with datura is very marginal. Unless you have 10 generations of ancestral knowledge to backup your procedure, or you're a fucking surgeon with dosing, I wouldn't.
We're talking about shrooms here. Add MAOIs if you must, or even grapefruit juice, but don't add datura on your own if you know shit all about it.
I don't care if other ppl think I'm a fear-mongering <snip>. Datura is the only drug that scares the living hell out of me, and I'm very experienced with etheogens.
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Thorns Have Roses
Bluelight Crew
foreigner said:
Not gonna try to dissuade you from your disinterest, nor do I want to continue this derailment I have contributed to, but I'd like some more details about these experiences. Throw me a PM or something. How much previous datura experience did these people have, had they tested the alkaloid content of the plant through titration of homogeneous material harvested all at once, what part of the plant did they use (whether it was in its growth or generative phase also matters, well obviously seeds and flowers can only be gathered in the latter though), how much plant matter had to be used to achieve desired effect level in previous experimentation, what species of datura was it, etc. etc.? Effects on the combined experience relative normal also being a matter of interest, of course.