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Scientific reason for the high

R

Rude Rabbit

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Feb 22, 2010
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What exactly causes the high? Is it when THC binds to the cannabinoid receptors CB1 and CB2? If the body produces its own cannabinoids why can't we automatically get high? Is it because we have built up a tolerance to our own cannabinoids?
 
DMT in your brain is just a theory. it hasn’t been proven. For the cannabis question, i think it is because we have a chemical in our brain called anamidine or w.e, but the THC mimics it and causes dopamine in certain parts of the brain? Not sure if this is right though??
 
I'm sure it alters the way neurons function in the hypothalamus, thus distorting our perception? I confess that's a very basic, and incomplete, explination, hopefully someone will elaborate.
 
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it stimulates receptors that expect to be stimulated differently by a different chemical, therefore tricking your body and producing a different effect because it is not used to these receptors being used this way. the chemical THC is foreign to your body so it will produce an effect, your body produces some chemicals that are close to it

this is what i remember from psychology class, but i was stoned so it may be distorted. hehe
 
it's higher levels of activity than are produced by natural stimuli and homeostasis. aslo, it likely increases CB activity in different areas of the brain that do not often experience simultaneous increases in activity from natural stimuli. and maybe the natural stimuli that increase CB activity levels also have an effect on other pathways and NTs that marijuana's active chemicals do not.
 
Cannabis has psychoactive and physiological effects when consumed. The minimum amount of THC required to have a perceptible psychoactive effect is about 10 micrograms per kilogram of body weight. Aside from a subjective change in perception and, most notably, mood, the most common short-term physical and neurological effects include increased heart rate, lowered blood pressure, impairment of short-term episodic memory, working memory, psychomotor coordination, and concentration. Long-term effects are less clear.
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i got that off google, cool huh?
 
implying that you can get lots of cool things from google
so maybe OP should of searched google firstly
 
Visionary_Kpsycho said:
DMT in your brain is just a theory. it hasn’t been proven. For the cannabis question, i think it is because we have a chemical in our brain called anamidine or w.e, but the THC mimics it and causes dopamine in certain parts of the brain? Not sure if this is right though??
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Anandimide -
an endorphin (natural painkiller).
its in cannabis too.


and the scientific reason is that man has evolved over hundreds of thousands of years with cannabis, so we have cannabinoid receptors in out brains.
the compounds from the ingested material bind to these receptors, making you high.



and yes, it has been proven that we naturally produce DMT in our pineal gland.
it is what makes us dream.
speculation is that in near death experiences, the flash of white light is a flood of dmt into the brain.
(same whiteness is gained with HIGH dose DMT trip)
every living creature (near enough) does the same, and the majority of plants etc contain it naturally.
 
^you wrote that anandamide is "an" endorphin and i almost stabbed my computer and jumped out the window.


endorphin controls actions needed for biological function, why opiate/oid withdrawl can and will induce severe physical withdrawl symptoms after prolonged use.


Anandamine is only one of the natural cannabinoids that occur in the brain. It is not even the main one. Cannabinoids bind to C1 and C2 which control perception and some cognitive actions. Conclusively, many have gone cold turkey from cannabis with zero physical withrawl symptoms; with opiates the number is more like .0001%-none as opposed to about 95% for cannabis.

It even makes more sense:endorphin-orphin-orphine-morphine.

endorphin and endomorphin and enkephalin are main peptides for happiness that will manifest itself in severe deppression upon cessation. After one day or so of irritability most former cannabis users feel sharp as a nail and ready to live.
 
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