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salvia acting like a pseudo MAOI?

chugs

chugs

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Feb 23, 2004
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Recently i've been reading about Mirtazapine and it's interactions with other drugs and thought i might share something i may have discovered, yes i am a great discoverer, all prostrate yourselves before my undeniable logic.

In the erowid vault there is a experience written about a person who consumed salvia whilst on Mirtazapine.

http://www.erowid.org/experiences/exp.php?ID=32885

The experience clearly shows a hypertension event, or if you will, a crisis.

When reading a stock standard description of Mirtazapine from http://www.aafp.org/afp/990101ap/159.html it explains that Mirtazapine shouldn't be taking with

Drug-Drug Interactions

Multiple hepatic pathways are used in the metabolism of mirtazapine, so clinically significant drug-drug interactions are unlikely to occur.3,25 However, little is actually known about drug-drug interactions in the clinical setting.25 Because of its sedative effects, alcohol should not be taken with mirtazapine and excessive sedation may result when it is used with other sedating drugs, such as benzodiazepines.3,26 Mirtazapine should not be used within 14 days of the use of a monoamine oxidase inhibitor because of the possibility that a hypertensive crisis will be triggered.12

could salvia have some pseudo MAOI like affects that were brought on by the Mirtazapine?

Has anyone taken MDMA & Salvia and noticed any physiological (since MDMA has well known and strident affects when interacting with a MAOI?)
 
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I read a report on Erowid of someone claiming to have taken salvia while on MDMA and they said it prolonged the duration of the salvia trip, not much else though.
 
*shrug*... I doubt it.

It's hard to know whether it was a hypertensive event or not. Could have been all kinds of things, panic etc....
 
Actually, that probably isn't far from the truth. I've frequented a nutrition board where a guy swore by salvia as the most potent antidepressant.
 
Well, drug interactions are sth unpredictable, which cannot always be described as a combination of the effects of two or more drugs. I doubt that there would be such a contraindication in the manual that says "Do not take when smoking Salvia Divinorum." I mean that what happened might have nothing to do with MAOI, but just have been triggered by the combination. It might, as well, not happen the next times or with other people. Nothing is known about this.
 
uacvax said:
Actually, that probably isn't far from the truth. I've frequented a nutrition board where a guy swore by salvia as the most potent antidepressant.
Click to expand...

I think salvia as an antidepressant is something learnt psychologically from the trip, rather than the chemicals it releases from the brain (since i've read that people say it can cure depression for weeks, months, or longer).
 
interestingly there are no MDMA + Salvia experience in erowid.
 
That's a bit of a dubious statement. I mean, assuming that it is an antidepressant it seems relatively valid, seeing as that's the only way we've been able to demonstrate that it acts, but kappa agonists and salvinorin have a pro-depression like behaviour effect [1].
 
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