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  • BDD Moderators: Keif’ Richards | negrogesic

Safe ammount of acetaminophen?

^Untrue. Paracetmol/apap/acetimpfapben (yep) is highly hepatoxic. Either chronic use, or a one of use of about 175mg/kg body weight can kill. Paracetemol overdoses are the most common cause of liver failure.
 
shrimps2004 is right. ! gram per dose, 4 grams per day is the recommended safe dose
 
Fresco said:
Take lecithin beforehand and your liver will be protected

I would take 2,000 to 3,000 mg of lecithin to be safe
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I've seen you talking about this several times--do you have any sources or citations for this information? Sounds interesting...
 
7 g in one dose has caused fatalities. 5 g would probably temporarily damage your liver but not quite kill you.
 
Cloud N9nE said:
I take 13 Lortab 10s at once which have 500mg tylenol each so thats 6500 mg of tylenol, youll be fine, I take 30 in a whole day!
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Your not supposed take more than 4000mgs in an hour. What you are doing is damaging your liver. Please don't tell other BLers that it's ok because it's not. You may not notice and damage to your body yet but it will happen.

Why don't you just do a Cold Water Extraction ?
 
Cloud N9nE said:
I take 13 Lortab 10s at once which have 500mg tylenol each so thats 6500 mg of tylenol, youll be fine, I take 30 in a whole day!
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That works for you because your liver has adjusted to this. If any regular person took 30 x 500 mg APAP they'd die on the spot no ifs, ands or buts about it.

This is a convenient reference for all aspects of APAP toxicity.
 
flacky said:
That works for you because your liver has adjusted to this. If any regular person took 30 x 500 mg APAP they'd die on the spot no ifs, ands or buts about it.

This is a convenient reference for all aspects of APAP toxicity.
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I'm sorry, but you're just as wrong as him. The liver does not adjust or acclimate to acetaminophen. It doesn't build up a tolerance and cannot become immune. His liver enzymes are probably through the roof. People have this sense that, if it doesn't kill me, it doesn't do any harm and it's just not true.
 
dokomo said:
I'm sorry, but you're just as wrong as him. The liver does not adjust or acclimate to acetaminophen. It doesn't build up a tolerance and cannot become immune. His liver enzymes are probably through the roof. People have this sense that, if it doesn't kill me, it doesn't do any harm and it's just not true.
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The upregulation of liver enzymes is the definition of a tolerance or acclimation.
 
Hmmm, Your wikipedia source says this:

Paracetamol toxicity is caused by excessive use or overdose of the analgesic drug paracetamol (called acetaminophen in the United States). Mainly causing liver injury, paracetamol toxicity is one of the most common causes of poisoning worldwide...
With progressive disease, signs of liver failure may develop; these include low blood sugar, low blood pH, easy bleeding, and hepatic encephalopathy. Some will spontaneously resolve, although untreated cases may result in death.

Damage to the liver, or hepatotoxicity, results not from paracetamol itself, but from one of its metabolites, N-acetyl-p-benzoquinoneimine (NAPQI). NAPQI depletes the liver's natural antioxidant glutathione and directly damages cells in the liver, leading to liver failure.
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Which basically contradicts what you stated.
 
flacky said:
The upregulation of liver enzymes is the definition of a tolerance or acclimation.
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Actually, it's a desperate attempt by the liver to neutralize harmful substances when it's under substantial stress.
 
I'll leave it at this --- There's a reason that people who pop Vicodins all day don't start turning yellow but the general population does.
 
flacky said:
I'll leave it at this --- There's a reason that people who pop Vicodins all day don't start turning yellow but the general population does.
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Yeah, and theres a reason everything doesnt just fall off of the earth, because its flat right?

Show me some solid scientific, peer-reviewed evidence of exposure-acquired acetaminophen tolerance and I'll gladly agree with you.

People have different natural abilities to process acetaminophen. This ability varies even for individuals on a daily basis depending on factors like food, other medications, etc.
 
following is not backed up with sources so take it as a some dude talking on the net.....


I read a paper on high dosage regular usage of acetaminophen, where it was noted liver enzymes increased with a daily dose of the maximum 4000mg range, it was also noted that over a period of time, the liver enzymes would then normalize as the liver became *used* to the load that was being placed on it.

I always took it that, the liver was working harder, and that then, you better let it just deal with that, adding aditional toxins to it, would be be extremly harmfull as the liver would be at full throttle all ready.....

the liver cant become immune to the toxins it deals with, it just works harder to deal with them, eventually something is going to break.

i know this is a bit of a mindless ramble,
30 pills containing acetaminophen will kill you, if not today, it will catch up to you, and you will have serious liver issues, I would love to be proven wrong.
im no doctor but no-way avoiding issues at that dose....surely ?
 
flacky said:
http://arjournals.annualreviews.org/doi/abs/10.1146/annurev.pharmtox.40.1.581?journalCode=pharmtox

This article makes references to "acetaminophen tolerance." Unfortunately, I don't have the database access to get it.
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I think I may understand where the confusion is.

I have access to the article. The tolerance that this article refers to is the decrease in liver enzyme levels after acetaminophen dosing over time. Though enzyme levels might decrease, the liver is just experiencing toxicity all the same. A massive release of enzymes is a common hepatic response to stress, and these levels can decrease over time but the toxicity is still happening and there is no tolerance to this toxicity. The liver doesn't become resistant to acetaminophen and its damaging effects, it simply lessens its enzyme excreting response.
 
I wish I had database access, because I've heard people with good qualifications agree with my position before and lack of database access clips my wings per se.
 
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