Roxindole

[Smyth]

Anybody ever heard of this? Maybe it is not very popular because it flirts with the dreaded "THP" functionality.

 

[hussness]

It's on biopsychiatry.com, which is where I'm guessing you got it from too. I looked it up in the exhaustive drug guide for the US, and it wasn't listed. What I would be most interested in would be evidence from the clinical trials indicating that a THP connected in this fashion is NOT neurotoxic.

 

[Smyth]

It probably is neurotoxic though. Not the compound but its N-dealkylated metabolite. I guess that might be why it is indicated for use in schizos?

 

[hussness]

I don't understand why neurotoxicity justifies its use in treating schizophrenia. Are all tertiary amines dealkylated by metabolic enzymes? If so, which family of enzymes is this?