Stimulants Ritalin + Ethylphenidate r/c

[50shadesofDave]

Hi folks, i work in a job that requires 100% concentration for 8hrs, i struggle to wake up in the mornings (it takes a few hours) before i feel ready to take the day on, i've tried many coffee brands but it does jack for me, i don't and won't go down the speed route, but from memory of my rave days i feel like i need that first 15-20 mins jolt you get when it starts working.

I've been reading about ritalin and the r/c ethylphenidate and wondered if anyone had experience of the latter, is it similar to ritalin as i've tried it before and found it very productive, i just find it hard to get so i'm looking for ethylphenidate but only if it is a similar drug.

Thank you folks, take care.

 

[MedicinalUser247]

Ethylphenidate itself is more euphoric. Methylphenidate can be metabolized into Ethylphenidate when combined with Alcohol. I don't recommend you doing it though because it gives you one hell of a hangover.

 

[Pissed_and_messed]

One thing I have to warn you about.

When I was doing amphetamine paste daily, because I have so bad mornings you know (always have), it was kinda hard to fall asleep when I had prepared my morning line to the night table.

I wish you won't face same kind of issues, but if you notice that your sleep goes to shit even tho you should not be affected anymore when going to sleep, you might know the reason then.

 

[Bleaney]

I used a fair bit of ethylphenidate when it was available in the UK as an RC, and snorted and bombed the effects are the same, IIRC. Although I cant be 100% sure on that after such a long time ago.)

Definite increase in energy and focus, but also a huge increase in libido or lechery etc, however you want to put it. Maybe it was just me, but I think that was quit a common side effect from Ethyl.

With Methylphenidate taken orally it feels like pure energy for the brain, and that feels good in itself. Although I have been diagnosed with ADHD so I'm not sure if us ADHDers get more functionality benefits than non ADHDers. Apparently the science and 'you tube experts' say so, but I'm not so sure on that.

Also I dont find Methylphenidate when swallowed, either the IRs or XRs, do anything much sexually, but that can change pretty drastically if you're ever naughty and crush and sniff an IR.

 

[Bleaney]

Ethylphenidate itself is more euphoric. Methylphenidate can be metabolized into Ethylphenidate when combined with Alcohol. I don't recommend you doing it though because it gives you one hell of a hangover.

Only tiny amounts get converted AFAIK, amounts so little that it wont feel like Ethylphenidate. (I looked into it in some depth, as the possibility intrigued me. And I've also had a couple of trial alchohol and methyl sessions, and I couldnt feel any Ethylphenidate type feelings)

 

[50shadesofDave]

Cheers Bleaney, just being able to wake up within two hours would be a bonus at the moment, i'm working everyday up to 24th December and i'm knackered, the morning weariness isn't helping and coffee just doesn't help, i've been downing a large can of redbull on the way to work just to help.
I have seen a site with ethyl but wanted a trip report first.

Thanks folks.

 

[LoginNotSecure]

Ethylphenidate hurt the inside of my nose quite peculiarly in that it would rip it to shreds and then scab within a couple of hours. And it's pretty damn hard not to pick the scab!

 

[Bleaney]

Yeah it was brutal when sniffed. I remember that much, but I can't remember too much more about that ROA. Which probably means that I just bombed it most of the time. Due to the nose pain and damage.

Have you considered Modafinil @50shadesofDave ?

It is effective as a functional stimulant and 'wakefulness promoter' and easy to get on the clearnet from within the UK. Ethyl will probably meaning ordering from an RC retailer from overseas and then you'll have the customs seizure risk, and any potential legal follow ups, unless the vendor is clever with their stealth.

Also can you be sure it is Ethylphenidate? RCs seem to have their brief period 'in the sun' and then mostly seem to vanish, never to be seen of again.

Some stims being tested on Wedinos of late seem to be testing as 3MMC (IIRC) and that seems to be for people ordering Mephedrone, and they are getting this much less good successor instead.

 

[3DQSAR]

I found ethylphenidtate to be far smoother than Ritalin BUT I think it's worth noting that most vendors sell a product that contains all 4 stereoisomers. I don't know why because it's not much extra work to epimerize the product into it's trans isomers. That makes the product notably more potent and notably more euphoric.

Medically I suspect that mixture of isomers was initially marketed with a view to 'evergreening' the product., to reduce initial production costs and possibly to REDUCE the euphoria. But those are all guesses.

One thing we predicted would be a decent stimulant is the closely related phenyl(piperidin-2-yl)methanone. But it turned out that what appears to be a very simple compound to produce was actually rather difficult. Reaxys provided a reference that proved not to work. In the end we wondered if we could legally acquire phenyl(piperidin-2-yl)methanol and perform an oxidation. But that proved to be problematic in itself for a few reasons.

Long, long ago a few of us would occasionally indulge in a 'sidewinder' in the form of Dexedrine and diazepam. One for one. We didn't go crazy, only two or three of each but initially one feels all of the benefits of Dexedrine without any of the side-effects and the longer duration of the diazepam meant that the experience was dynamic. Like a very gentle slope to relaxation.

We never used the mixture as an alternative to living, we used it and went to visit museums, art galleries, stately homes and so on. Things that require long but not strenuous exercise interspersed with the need to focus on information. But that's 30+ years ago. But even then I only ever trusted medicines obtained from local pharmacies OR things whose provenance and purity I knew explicitly.

I'm always reminded of that Nordic vendor who confused bromo-Dragonfly with another, much less potent compound which resulted in his death and that of six others. That's why all pharmacies apply the '2 man rule' i.e. one person fills a prescription, another has to confirm that the prescription is correct.

 

[50shadesofDave]

Yea i tried modalert with no real effect, other than an intense rash all over my body.

 

[3DQSAR]

Yea i tried modalert with no real effect, other than an intense rash all over my body.

I was given a single 200mg tablet. I can honestly say that I didn't notice any effects whatsoever. It had been obtained legally via a prescription but I couldn't work out HOW such a drug could be abused.

Now I'm extremely sensitive to stimulants which has only got worse as I've aged so I presumed if anyone would notice the effects, it would be me.

I read a very informative paper which detailed the development of psychostimulants. I don't recall every detail but it was something like this:

amphetamine -> phenmetrazine -> desoxypipradrol -> tetrahydroisoquinolines (nomifensine/dichlorfensine etc.) -> hexahydropyrrolo[2,1-a]isoquinolines (e.g.JNJ-7925476 Mc-N5652)

What's important to note is that in all cases the researchers extensively studied that ring-substitution patterns.

Obviously as synthetic complexity and the increase in enantiomers has made each generation less facile than the last to produce but not impossible. I don't have IC50 data on the later classes but at lest they all seemed to use the previous generation as the baseline.

DAT NET 5HT (nM)
Dichlorfensine 10.9 8.80 10.3
3,4-dichloro 0.99 0.68 1.8

Likewise if one interrogates the papers discussing the THIQs, at least some of them will refer back to ring-substituted PEAs.

But before people ask, I'm reasonably sure that unlike the PEAs, one cannot introduce 5HT2a affinity.

 

[3DQSAR]

Yea i tried modalert with no real effect, other than an intense rash all over my body.

I was given a single 200mg tablet. I can honestly say that I didn't notice any effects whatsoever. It had been obtained legally via a prescription but I couldn't work out HOW such a drug could be abused.

Now I'm extremely sensitive to stimulants which has only got worse as I've aged so I presumed if anyone would notice the effects, it would be me.

I read a very informative paper which detailed the development of psychostimulants. I don't recall every detail but it was something like this:

amphetamine -> phenmetrazine -> desoxypipradrol -> tetrahydroisoquinolines (nomifensine/dichlorfensine etc.) -> hexahydropyrrolo[2,1-a]isoquinolines (e.g.JNJ-7925476 Mc-N5652)

What's important to note is that in all cases the researchers extensively studied that ring-substitution patterns.

Obviously as synthetic complexity and the increase in enantiomers has made each generation less facile than the last to produce but not impossible. I don't have IC50 data on the later classes but at lest they all seemed to use the previous generation as the baseline.

DAT NET 5HT (nM)
Dichlorfensine 10.9 8.80 10.3
3,4-dichloro 0.99 0.68 1.8

Likewise if one interrogates the papers discussing the THIQs, at least some of them will refer back to ring-substituted PEAs.

But before people ask, I'm reasonably sure that unlike the PEAs, one cannot introduce 5HT2a affinity. I know this might seem obvious, but then I realize that some genius actually had produced and attempted to sell 2,5-dimethoxy-4-bromo aminorex.

 

[izo]

I Found ethylphenidate to be a Bit less good than ritalin. Still an ok stimulant but there are better ones out there. But it’s ok if you Need something for focusing.

 

[3DQSAR]

I Found ethylphenidate to be a Bit less good than ritalin. Still an ok stimulant but there are better ones out there. But it’s ok if you Need something for focusing.

As I mentioned, the people who introduced ethylphenidate failed to perform the extra step that reduced the 4 enantiomers to 2. We did and the product was notably better. Now we didn't isolate the active isomer as it would have more than doubled the cost but we did have samples made. It turns out that if one consumes only the active, it's duration is shorter or more specifically, once it begins to wear off, it totally wears off within a couple of hours.

 

[freshhood]

I've tried ethylphenidate years ago and it blows all the other stims I've tried out of the water. It's sad that it's out of the market everywhere. If someone knows how to convert methylphenidate to ethylphenidate please let me know

 

[Bleaney]

I've tried ethylphenidate years ago and it blows all the other stims I've tried out of the water. It's sad that it's out of the market everywhere. If someone knows how to convert methylphenidate to ethylphenidate please let me know

Apparently alcohol converts methylphenidate to ethylphenidate within the body. But not to any noticeable extent, it seems to me.

I've taken normal therapeutic level doses of methyl and moderate to heavy amounts of alcohol a few times. I guess I just felt more awake than I would have done without the stimulant.

It's possible that you'd have to push the methylphenidate dose an unknown amount higher, and maybe also the amount of alcohol and speed of consumption. This kind of thing happened naturally when I used to take amphetamines and drink, but I dont think methylphenidate is as recreational as amphetamines.

tl:dr Just speculating, but it seems you'd have to push the methylphenidate or alcohol consumption doses pretty high to ever experience any of the conversion that alcohol is meant to do in the body, after consuming both.

 

[Pissed_and_messed]

Yea I read about it and it asks for the liver enzymes+alcohol+methylphenidate I don't remember why. And the rate of conversion is not really that remarkable so the amount of alcohol in blood has to be really high for any significant amount of ethylphenidate to be formed.

 

[3DQSAR]

Apparently alcohol converts methylphenidate to ethylphenidate within the body. But not to any noticeable extent, it seems to me.

I've noted the fact that this observation turns up quite regularly.

Sci-Hub | Methylphenidate and its ethanol transesterification metabolite ethylphenidate: brain disposition, monoamine transporters and motor activity. Behavioural Pharmacology, 18(1), 39–51 | 10.1097/FBP.0b013e3280143226

The wording of the summery strikes me as being quite telling. It does not assert that the results have any clinical significance but notes that ' The consequences of EtOH consumption on the therapeutic effects or abuse liability of MPH remains an area of active clinical investigation (Patrick, 2005; Patrick et al., 2006).'

So yes, transesterification is a thing, but the amounts involved don't appear to be clinically significant.

I suppose if people are truly concerned swapping to the French medication levophacetoperane (essentially the reversed-ester of methylphenidate) would solve the issue.

BTW levophacetoperane suggests that possibly the seemingly simpler compound, Phenyl(2-piperidinyl)methanone MAY be of interest and it is mentioned in a few papers (according to PubChem) but as it turned out, synthesis was not as easy as it seemed.

 

[peace seeker 76]

I used a fair bit of ethylphenidate when it was available in the UK as an RC, and snorted and bombed the effects are the same, IIRC. Although I cant be 100% sure on that after such a long time ago.)

Definite increase in energy and focus, but also a huge increase in libido or lechery etc, however you want to put it. Maybe it was just me, but I think that was quit a common side effect from Ethyl.

With Methylphenidate taken orally it feels like pure energy for the brain, and that feels good in itself. Although I have been diagnosed with ADHD so I'm not sure if us ADHDers get more functionality benefits than non ADHDers. Apparently the science and 'you tube experts' say so, but I'm not so sure on that.

Also I dont find Methylphenidate when swallowed, either the IRs or XRs, do anything much sexually, but that can change pretty drastically if you're ever naughty and crush and sniff an IR.

hiya just a quick question
can u crush and snort medikinet 30mg (Methylphenidate) extended release Capsules? any Dangers?

 

[3DQSAR]

hiya just a quick question
can u crush and snort medikinet 30mg (Methylphenidate) extended release Capsules? any Dangers?

You would need to check the list of excipients but in general, it's unpleasant rather than having any more risks than consuming methylphenidate via a parenteral route. I am unaware of any specific dangers although if you take other medication, check compatibility.