RCs Report and Question(s) about new Methaqualone analogue

[Mana0909]

Hello,

Yesterday, I received my "Mephenaqualone," a relatively new analogue from 2023. It has effects similar to the original substance "Methaqualone," but it is significantly more potent.

I would describe it as a Benzodiazepine with moderate cognitive euphoria (such as talking a lot) and moderate motivation enhancement. Additionally, there is one aspect that I particularly appreciate: while all Benzodiazepines numb your emotions to some degree, Mephenaqualone does not. Substances like Clonazepam, Flunitrazepam, and Rilmazafone are milder in this regard, whereas Alprazolam, Clonazolam, Bretazenil, and Lorazepam can induce dysphoria and make you feel completely emotionless. Mephenaqualone, on the other hand, only numbs negative thoughts and replaces them with euphoria, despite also being a positive allosteric modulator on GABA-A receptors.

I am interested in knowing the potency comparison between Mephenaqualone and various Benzodiazepines. My pellets are violet and contain 4 mg of Mephenaqualone, but there are also 2 mg options available. If anyone could provide a potency comparison of 2 mg Mephenaqualone to Diazepam, Oxazepam, Clonazepam, Alprazolam, etc., it would be extremely helpful.

Additionally, I would appreciate any opinions on "Mephenaqualone" and how it compares to Benzodiazepines in your experience.

Thank you.

 

[canadianpeduser]

Never heard of this; Interestingly classified as a hypnotic sedative, like zopiclone is. Wondering how these would measure up against one another.

 

[Bleaney]

Sounds (and looks like following a brief search online,) more like an old school barbiturate, rather than a benzo.

"It is an analogue of methaqualone, sharing a similar chemical structure and pharmacological effects."

psychonaught wiki.

If this is the case, it's a possible rare
opportunity for some people to get some barbs/ barb analogues. As similar to the famous quaaludes / mandrax as most younger people will ever get.

I only hope it's not as dangerous as the previos methaqualone analogue, etaqualone, where the oral dose needed to produce a high was dangerously close to the lethal level dose.

Sublingual dosing was meant to be much safer, but users complianed of chemical burns etc, so i was put off for some time, but eventually tried etaqualone s/l and it was very nice.

I also look forward to finding out more about Mephenaqualone. Must admit I'd never heard of it before.

 

[Mana0909]

I have had two experiences with Zopiclone. Overall, I would say that Zopiclone induces mild euphoria, which is weaker than that of Mephenaqualone (RC Quaalude). Zopiclone makes you significantly more tired and slows your cognitive processes, leading to sleep. In contrast, RC-Quaalude does not induce such drowsiness. Instead, it provides motivation, and when you go to bed, it feels incredibly relaxing and comforting, similar to the effects of opioids.

On Mephenaqualone, you have a strong desire to engage in conversation, and it feels as though all negative thoughts are numbed. The euphoria experienced is a blend of Phenibut and opioids.

Although Zopiclone can cause mild euphoria, its other effects, such as muscle relaxation, sedation, and anxiety suppression, are weaker compared to RC-Quaalude and other benzodiazepines.

Zopiclone is more akin to a light benzodiazepine than a light Quaalude. The substance that can be compared to Quaaludes is Phenibut in strong doses. I would say that Phenibut is a lighter version of Mephenaqualone (RC Quaalude).
Zopiclone is more like a light version of Temazepam

 

[Mana0909]

Sounds (and looks like following a brief search online,) more like an old school barbiturate, rather than a benzo.

"It is an analogue of methaqualone, sharing a similar chemical structure and pharmacological effects."

psychonaught wiki.

If this is the case, it's a possible rare
opportunity for some people to get some barbs/ barb analogues. As similar to the famous quaaludes / mandrax as most younger people will ever get.

I only hope it's not as dangerous as the previos methaqualone analogue, etaqualone, where the oral dose needed to produce a high was dangerously close to the lethal level dose.

Sublingual dosing was meant to be much safer, but users complianed of chemical burns etc, so i was put off for some time, but eventually tried etaqualone s/l and it was very nice.

I also look forward to finding out more about Mephenaqualone. Must admit I'd never heard of it before.

No need to worry, Mephenaqualone is actually even safer than the original Methaqualone. However, you were right—almost all analogues were highly dangerous and could even be fatal when overdosed.

Mephenaqualone is not a barbiturate because it is not a GABA-A agonist. RC-Quaalude (Mephenaqualone) is similar to benzodiazepines, acting as a positive allosteric modulator on GABA-A receptors. The difference is that it shows affinity for the alpha-6 (α6) and alpha-4 (α4) receptors, as well as other sub-receptors within the GABA-A sector. In contrast, normal benzodiazepines only show affinity for α1, α2, α3, and α5 (α = alpha).

Specifically, Mephenaqualone binds to the following GABA-A receptor subtypes:

• α1, α2, α3, α4, α5, α6: These subunits are involved in various effects such as sedation, anxiolysis, muscle relaxation, and anticonvulsant properties.
• β2, β3: These subunits contribute to the overall inhibitory effects of GABA-A receptors.
• γ2S: This subunit is important for the benzodiazepine binding site and modulates the effects of positive allosteric modulators.

The substance is new and highly addictive, significantly more so than typical benzodiazepines like Alprazolam, Diazepam, Clonazepam, etc. However, it is considered safer than Methaqualone and its analogues due to its specific receptor binding profile, which reduces the risk of severe side effects and overdose.

Stay safe.

 

[Bleaney]

So, in laymans terms, it's an analogue of Methaqualone, but more similar to benzodiazepines than barbiturates?

Or, is it more similar to barbs than standars benzos, even though it's not a barbiturate?

Or do both statements or questions apply to some extent? With it potentially being some kind of 'cross over' between the 2 classes?

Apologies but I'm going to be lost if you go too deep into drug related brain chemistry / neuro psychology (all the stuff about different receptors). What is even the proper name for that subject?

You seem to be saying that it's not a barbiturate because it's not a gaba A agonist, but it seems to have a lot of 'binding' activity going on with specific gaba-A receptor subtypes. I guess i need to know the difference between 'binding' and 'agonists'. But when people start talking about this stuff including agonists and antagonists it's like I have a mental block about the whole subject. Or have all you guys that talk about this stuff got masters degrees in whatever these topics are known as?

I mean, I guess I roughly followed the above. But I am still confused as hell tbh.

All I know for sure is that I sure am very partial to GABA enhancing subtsances, along with dopamine boosting ones. And that could be very simply accounted for by my brain having defincies in these areas an account of Autism and ADHD, where it has been shown that each condition is correlated with deficiencies with the levels of each within the brain. And as a result many of us are inclined to try self medicate our way to a better adjusted brain state or state of mind. Call it what you will. Or at least with ADHD you can obtain legit meds and scripts that actually work.

I should add that this new substance would not appear to be a candidate for succesful self medicating, on account of it's seeming highly addictive nature, and doubtless horrific w/d syndrome. Much more one for occasional recreational use by the sounds of things.

 

[Mana0909]

Clarification on Mephenaqualone​

Oh, I'm sorry if I confused you earlier. Let me explain it again:

Mephenaqualone is essentially the same as Methaqualone, but it is 90-100 times more potent. Many say that 3.5mg - 4mg of Mephenaqualone is equivalent to 300mg of Methaqualone. Mephenaqualone has a similar effect spectrum to benzodiazepines, but it does not bind to the same receptors on the GABA system, nor does it bind to any barbiturate receptors. Its binding and effects are quite unique.

When you take 4mg of Mephenaqualone, it feels like (in my opinion) 1.0 - 1.25mg of Clonazepam, mixed with moderate to strong Phenibut/opioid euphoria. The main effect lasts for 3 1/2 - 4 hours, after which only the "benzo-like" effects remain, but the euphoria is gone.

There is nothing similar to Quaaludes or their analogues.

Regarding Cross Tolerance: Only partially. Benzos, Quaaludes (and also barbiturates) might bind to different receptors, but they all result in higher GABA and calcium concentrations. This is why some effects might be weaker when you have a tolerance, while others are not. The only drug that comes close to "Mephenaqualone/Methaqualone" is high-dosed Phenibut. Psychonautwiki might say that Mephenaqualone lasts 15-20 hours, and other sources even go up to 96 hours, but this only applies to the tranquilizer/benzo-like feelings. The euphoria and motivation are gone after 4 hours. That's why I say the effect lasts (after taking the pellet) for 4 hours.

Stay Safe, Mana0909

 

[Bleaney]

Clarification on Mephenaqualone​

Oh, I'm sorry if I confused you earlier. Let me explain it again:

Mephenaqualone is essentially the same as Methaqualone, but it is 90-100 times more potent. Many say that 3.5mg - 4mg of Mephenaqualone is equivalent to 300mg of Methaqualone. Mephenaqualone has a similar effect spectrum to benzodiazepines, but it does not bind to the same receptors on the GABA system, nor does it bind to any barbiturate receptors. Its binding and effects are quite unique.

When you take 4mg of Mephenaqualone, it feels like (in my opinion) 1.0 - 1.25mg of Clonazepam, mixed with moderate to strong Phenibut/opioid euphoria. The main effect lasts for 3 1/2 - 4 hours, after which only the "benzo-like" effects remain, but the euphoria is gone.

There is nothing similar to Quaaludes or their analogues.

Thanks for the further clarification. It seems I might have been confused by mistakenly thinking that Methaqualone was a barbiturate. But it seems that is not the case. I think it has been quite commonly stated on line that it was?

But I'm still confused about the following entry on Wikipedia

"Methaqualone is a hypnotic sedative. It was sold under the brand names Quaalude."

Is this not correct?

Otherwise I dont understand how it can be essentially the same as Methaqualone, and yet have nothing similar to Quaaludes, which were just a brand name of methaqualone.

 

[Nas47]

some analogue of metaqualone...never tried even this...meta\qualuds stuff...but is a strong hypnotic as i remeber,may be some barb?nevr used in meds.here...this stuff could be more or less potent

 

[Mana0909]

Yes, that is correct. I'm just using the name "Quaaludes" also for Mephenaqualone because it is essentially the same as the original "Methaqualone." Sorry if this was confusing.

Methaqualone was initially a replacement for barbiturates, which were highly dangerous. Many thought that after barbiturates, the first benzodiazepine "Chlordiazepoxide (Librium)" came in 1963, followed by "Diazepam (Valium)" in 1965.

However, this assumption was incorrect. In 1951, Methaqualone (brand name: "Quaaludes" or "Lemon714") came on the market. It was highly successful because it was significantly less dangerous than barbiturates. The difference is that barbiturates are full agonists on GABA-A receptors, while Quaaludes only bind to a few receptors in the GABA-Alpha sector. Barbiturates bind to the entire sector, on all sub-receptors, and benzodiazepines do the same.

The difference is that benzodiazepines bind to different GABA-Alpha sub-receptors than Quaaludes/Methaqualone, meaning some effects might be similar, but others are not.

Stay Safe,Mana0909

 

[Mana0909]

Barbiturates: Bind to the entire GABA-A (Alpha) sector, meaning all the sub-receptors.
Methaqualone/Mephenaqualone: Bind to some GABA-A (Alpha) sub-receptors, but only selective ones.
Benzodiazepines: Bind like Methaqualone/Mephenaqualone to some selected GABA-A sub-receptors, but on different sub-receptors than Mephenaqualone.

Effect: All of them lead to a higher GABA concentration and a larger calcium channel, resulting in the typical tranquilizer effects. Some effects are stronger, some weaker, and some different. But overall, they lead to the same result.

- Mana0909

 

[emkee_reinvented]

Clarification on Mephenaqualone​

Oh, I'm sorry if I confused you earlier. Let me explain it again:

Mephenaqualone is essentially the same as Methaqualone, but it is 90-100 times more potent. Many say that 3.5mg - 4mg of Mephenaqualone is equivalent to 300mg of Methaqualone. Mephenaqualone has a similar effect spectrum to benzodiazepines, but it does not bind to the same receptors on the GABA system, nor does it bind to any barbiturate receptors. Its binding and effects are quite unique.

When you take 4mg of Mephenaqualone, it feels like (in my opinion) 1.0 - 1.25mg of Clonazepam, mixed with moderate to strong Phenibut/opioid euphoria. The main effect lasts for 3 1/2 - 4 hours, after which only the "benzo-like" effects remain, but the euphoria is gone.

There is nothing similar to Quaaludes or their analogues.

Regarding Cross Tolerance: Only partially. Benzos, Quaaludes (and also barbiturates) might bind to different receptors, but they all result in higher GABA and calcium concentrations. This is why some effects might be weaker when you have a tolerance, while others are not. The only drug that comes close to "Mephenaqualone/Methaqualone" is high-dosed Phenibut. Psychonautwiki might say that Mephenaqualone lasts 15-20 hours, and other sources even go up to 96 hours, but this only applies to the tranquilizer/benzo-like feelings. The euphoria and motivation are gone after 4 hours. That's why I say the effect lasts (after taking the pellet) for 4 hours.

Stay Safe, Mana0909

Only taken Etaqualone, as comparison.
But my understanding was you can OD, on Qualones.
While on a Benzo that is very difficult/ impossible ?

If a re creative dose is close to a OD is important to know to.
Can you OD on solely -Qualones ? You have info on the LD50 ?

And if it can cause seizures, in contrary to benzo's.
I read that, can t confirm. Seems a point to investigate too.

Etaqualone when compared with Temazepam.
The only benzo i consider re creative.
,The differences were noticeable though ROA differed. Oral vs Vaped.

Temazepam 15 mg [maybe 30 mg would in strengt be a bit equal]
It had me walking with a grin, warm, mellow, walking in the sun.
Kicked in within 10 minutes and lasted a while with a slow decline to baseline.
Benzo naieve, so 15 fell pretty hard. Honeymoon phase.

A sprinkle of Etaqualone vaped, like it was made for it. I was in a Euphoric bliss,
5 minutes ? during. It took me down out, flat on the ground within seconds.
Wonder what if i had done 2/ 3 sprinkles ? Was back to baseline in no time to.
Would i have passed out and hit my head on the rocky ground.

Resembling Qualones and Benzos, they are not alike.
A comparison with GHB is closer, though in strength not effects.
My opinion, Etaqualone was nice and probably dangerous.

 

[Mana0909]

Only taken Etaqualone, as comparison.
But my understanding was you can OD, on Qualones.
While on a Benzo that is very difficult/ impossible ?

If a re creative dose is close to a OD is important to know to.
Can you OD on solely -Qualones ? You have info on the LD50 ?

And if it can cause seizures, in contrary to benzo's.
I read that, can t confirm. Seems a point to investigate too.

Etaqualone when compared with Temazepam.
The only benzo i consider re creative.
,The differences were noticeable though ROA differed. Oral vs Vaped.

Temazepam 15 mg [maybe 30 mg would in strengt be a bit equal]
It had me walking with a grin, warm, mellow, walking in the sun.
Kicked in within 10 minutes and lasted a while with a slow decline to baseline.
Benzo naieve, so 15 fell pretty hard. Honeymoon phase.

A sprinkle of Etaqualone vaped, like it was made for it. I was in a Euphoric bliss,
5 minutes ? during. It took me down out, flat on the ground within seconds.
Wonder what if i had done 2/ 3 sprinkles ? Was back to baseline in no time to.
Would i have passed out and hit my head on the rocky ground.

Resembling Qualones and Benzos, they are totally not alike.
My opinion, Qualones are nicer and probably way more dangerous.

Hello and Thanks,​

Yes, I agree with you. Quaaludes are, in my opinion, the best sedatives you can get. I'm so happy that I had and still have the chance to order Mephenaqualone pellets.

Etaqualone? Sounds very exciting. I had never heard of this analogue. I only know that Mephenaqualone is 99% the same as the original Methaqualone/Quaaludes (except for the potency). But you describe exactly how Mephenaqualone (I'm just calling them all Quaaludes from now on) kicked in. The euphoria was so beautiful; I wanted to talk, talk, talk, and I was so motivated to do stuff, to study, to do anything.

Yes, I understand what you mean when you say Quaaludes can't be compared to benzodiazepines. I also understand why they are illegal—they are way more addictive than benzodiazepines and don't really have a better "medical use." Temazepam is the benzodiazepine that I would count among the better ones, along with Clonazepam, Temazepam, and Flunitrazepam. The euphoria still can't be compared anywhere near to Quaaludes, but it can transform a bad day into a good one.

Now, to your question about whether you can overdose with Quaaludes. My highest dose was 28mg, and on top of that, 5mg Clonazafone (which is a Clonazepam prodrug...5mg Clonazafone equals 1.75 mg - 2.5 mg Clonazepam). Because I have a moderate benzodiazepine tolerance, I didn't experience a blackout. I would even say Quaaludes are way smoother than benzodiazepines and they trigger an insane craving, really. It's really difficult to overdose on Quaaludes and die from it because you would probably fall asleep before anything could happen. However, when you mix it with alcohol, it's an entirely different situation.

I don't like alcohol, so this is only from third-hand information, but when you mix those two drugs, it can cause severe brain, nerve, and organ damage. I didn't read much into it because, as I've said, I hate alcohol. Overall, I would say that Quaaludes, when taken solo, are a safe substance, but with an insane addiction and dependence potential that can be compared to opioids such as heroin or Roxy's.

EDIT: Did you mean that the effect only lasted 5 minutes on "Etaqualone" and that the comedown was pure horror?

Stay Safe,Mana0909

 

[emkee_reinvented]

EDIT: did you mean that the effect only lasted 5 minutes on "Etaqualone" and that the come down was pure horror?

Stay Safe,Mana0909

It kicked in so fast it was overwhelming, so laid down.
Otherwise would have happened anyway, experienced a euphoric bliss.
But was not what i would say stimulated, contrary a sedative euphoria.

After the peak there was a residual nice feel lingering,
sedation diminished. So functional again, sober within 30 minutes ?

And very GHB like imo.

Etaqualone/ France https://en.wikipedia.org/wiki/Etaqualone
350 mg tablets, dosages up to 500 mg.
When you have a gram/ 2 or 3 doses. Overpriced.

 

[Mana0909]

It kicked in so fast it was overwhelming, so laid down.
Otherwise would have happened anyway, experienced a euphoric bliss.
But was not what i would say stimulated, contrary a sedative euphoria.

After the peak there was a residual nice feel lingering,
sedation diminished. So functional again, sober within 30 minutes ?

And very GHB like imo.

Etaqualone/ France https://en.wikipedia.org/wiki/Etaqualone
350 mg tablets, dosages up to 500 mg.
When you have a gram/ 2 or 3 doses. Overpriced.

Thank You Very Much​

Do you know if it's safe? Mephenaqualone is a holy grail because it's the same as Methaqualone and isn't toxic.

Oh, now that you mention it, I have never taken GHB either. That's because I'm very scared of overdosing and ending up in the hospital. It's very important for me to never end up in an ambulance. When I take stimulants such as Vyvanse/Elvanse, I always make sure to have benzodiazepines and Quaaludes (Mephenaqualone) at home.

It sounds like Etaqualone has a similar potency to Methaqualone. But Mephenaqualone is 100 times more potent; around 2mg is a normal dose, and 4mg is considered "heavy" (reference: Psychonautwiki). Mephenaqualone is much more expensive than benzodiazepines.

Did you try to take Etaqualone orally or insufflated? How long did it last, and did you experience strong rebound symptoms?

EDIT: I removed the section where I listed the prices for RC-Quaaludes. If someone is interested in this or other substances, they can easily find the information online.

Stay Safe,Mana0909

 

[emkee_reinvented]

One oral try 250 mg did nothing, 750 left knowing 350 was a normal dose.
So never again. No no rebound, after 1 hit.
Is it dangerous, i think more then average. Falling on your head.
Concerning the one you mention it is potency that a danger.
No eyeballing that.

Toxic ? Must be info to be found on ?
Benzo s are, so cant see why Qualone s would not.

 

[Mana0909]

One oral try 250 mg did nothing, 750 left knowing 350 was a normal dose.
So never again. No no rebound, after 1 hit.
Is it dangerous, i think more then average. Falling on your head.
Concerning the one you mention it is potency that a danger.
No eyeballing that.

Toxic ? Must be info to be found on ?
Benzo s are, so cant see why Qualone s would not.

When I say "toxic," I mean it doesn't cause nerve, brain, or organ damage.
At least, not Mephenaqualone! However, this substance is very new, and we don't know every detail about it yet.

Not every benzodiazepine is toxic; it varies from substance to substance.
For example, substances like methaqualone can cause severe nerve damage.
The current information we have on Mephenaqualone suggests that it is similar to methaqualone and relatively safe.
There are no reports of death or injury, at least not on the internet.

Stay Safe, Mana0909

 

[Nas47]

safe...safe,,,idk abouth that....but damn sure is addictive

 

[Bleaney]

Thank You Very Much​

Do you know if it's safe? Mephenaqualone is a holy grail because it's the same as Methaqualone and isn't toxic.

Oh, now that you mention it, I have never taken GHB either. That's because I'm very scared of overdosing and ending up in the hospital. It's very important for me to never end up in an ambulance.

If its active in doses of 2 - 4mg raw powders that is going to be nigh on impossible to weigh accurately, leaving volumetric dosing in PG for example, and then measuring with a 2ml syringe as the only safe option. (Dissolving 100mg of the compound into 100 ml of PG would give a very straightforward 1:1 measuring ratio, with 1ml = 1mg)

If it dissolves in PG?

GBL / GHB was / is easy to dose safely if you use a 2ml syringe, as you can get very precise dosing that way, which is important as you know. As the margin between high and comatose OD is not huge. Just start low and gradually work up.

I was nearly always OK taking that stuff at home under relatively controlled conditions. However I ran into issues when trying to take it on a night out, as there were so many random factors involved that lead to me fucking up my doses. Such as asking for 1/2 a pint of lemonade, but getting 1 pint instead and then messing up my calculations, and indeed ending up in the back of an ambulance. Obviously you would need to research all the dose levels between low, normal, high, OD, and lethal, if you're ever going to pursue GBL or GHB.

It's one of the most enjoyabale substances I've ever tried, but you have to know what you're doing.

 

[Mana0909]

If its active in doses of 2 - 4mg raw powders that is going to be nigh on impossible to weigh accurately, leaving volumetric dosing in PG for example, and then measuring with a 2ml syringe as the only safe option. (Dissolving 100mg of the compound into 100 ml of PG would give a very straightforward 1:1 measuring ratio, with 1ml = 1mg)

If it dissolves in PG?

GBL / GHB was / is easy to dose safely if you use a 2ml syringe, as you can get very precise dosing that way, which is important as you know. As the margin between high and comatose OD is not huge. Just start low and gradually work up.

I was nearly always OK taking that stuff at home under relatively controlled conditions. However I ran into issues when trying to take it on a night out, as there were so many random factors involved that lead to me fucking up my doses. Such as asking for 1/2 a pint of lemonade, but getting 1 pint instead and then messing up my calculations, and indeed ending up in the back of an ambulance. Obviously you would need to research all the dose levels between low, normal, high, OD, and lethal, if you're ever going to pursue GBL or GHB.

It's one of the most enjoyabale substances I've ever tried, but you have to know what you're doing.

You don't have to worry,

it's not being sold as powder. Mephenaqualone is sold as pressed pellets. There are 2mg and 4mg options. I got the 4mg option and currently have 30+ left.
Next week, my next charge with 50 pellets will arrive—already hyped. Yes, the Quaaludes got me. In my opinion, it's the best substance ever.
I fully understand now why Quaaludes were made illegal worldwide.

GBL and GHB act on the GABA-B (Beta) receptors, like Phenibut and 2F-Phenibut. I'm still sad that Phenibut is now illegal in my country.
It was my favorite substance. If I were to rate Mephenaqualone with a 10/10, Phenibut would get a 9.8/10! That's how much I loved this powder.

I have to admit that I'm too afraid of taking GBL or GHB because overdosing is so easy with those substances.
Even though I've heard that the rush is pure pleasure and many call it the best substance, my decision and opinion won't change.

Despite this i'm already more than happy with my Quaaludes, but I'm happy for you that you enjoy those two substances so much.

Stay Safe, Mana0909