Benzos Raised Tolerence To Amnesia Due To Benzo Tolerence?

[muie]

Hi BL, i've been prescribed clonazepam 4mg/day since 04 to present, along with alprazolam or lorazepam up to 05 for panick attacks though still use them without script ocasionally. The past 10yrs of clonazepam use (daily) has raised my benzo tolerence as expected though when i try i different benzo like loraz or xanax, etc I feel the benzo effects much more than i would with plain clonazepam even if its an equivalent dose. When I started 1mg clonaz would beat 1mg xanax IMO, now 1mg xanax beats even 2mg-3mg clonaz.

This leads me to my question in terms of amnesia which i always hated about benzos (compared to old school choice like amobarbital, meprobamate, soma, etc).

Amensia is minmal to zero when i take my 4mg clonzepam/day, but if i take none or 1mg clonaz along with loraz or xanax i notice the obvious benzo effects (relatively well considering the tolerence factor) but about 3x as much I notice the amensic effects.

Ater 10yrs of benzo tolerence i find taking more than 2mg lorazepam even if i haven't taken any clonazepam or little to none (1mg) the amnesia becomes a huge factor. In other words more than 1mg lorazepam (2mg+) gives more amnesia than drinking a 3/4 bottle of vodka.

Shouldn't tolerence to benzo's amensic effects be on par with tolerence to the sedative effects?

Thanks in advance!

 

[sekio]

I think tolerance to the individual effects of benzos (amnesia, anxiolysis, muscle relaxation, sedation etc) build at differing rates.

 

[Jktm]

^ This.

And benzodiazepines of different types are likely to have different effects on you (hence why drugs like clonazepam/diazepam are used for seizures, lorazepam is only partially effective and is usually used intravenously, and drugs like alprazolam, triazolam, and estazolam are pretty much ineffective in this department). Clonazepam is a 3-dihydro benzodiazepine, while lorazepam is a 3-hydroxy benzodiazepine, and alprazolam is a triazolo benzodiazepine. It is also noted clinically that lorazepam tends to illicit a stronger amnesic effect than other benzodiazepines.