Opioids Questions about potential mixed Kratom and oxy/hydro withdrawal

[Mycophile]

So up until a few days ago I hadn't taken Kratom in months, but I hurt myself doing martial arts so I've been taking a dose a day as of a few days ago. I get Kratom wd very quickly and easily and it lasts long: 2 doses can be enough for a week's worth of annoying WD. On the other hand, whenever I have been prescribed hydrocodone or oxycodone, so long as I take prescribed doses, i get no WD.

So, in a couple days I have a doctor's appointment and they will hopefully give me some hydro or oxy to use to sleep because I'm having trouble sleeping due to pain and I can't sleep on kratom cause even though it makes the pain go away I find it stimulates me. So I would then be taking hydro/oxy at night while mildly dependent on Kratom.

I have never been in this situation before where I was using and at least a little dependent on Kratom while then switching over to a traditional opioid, so I'm wondering, what it is likely to happen?

Like, if I stopped Kratom right now I'd have 5-7 days of wd, but what if I stop taking Kratom during the day but I'm taking small amounts of oxy/hydro at night which wouldn't normally be enough to cause dependency? Will I be going through Kratom WD during the day and then have it go away at night because of the oxy or hydro?

Or what if (cause yes, I enjoy Kratom and it helps for pain and irritability) I don't immediately stop taking the Kratom and I was taking some during the day and then at night taking Oxy/hydro: would I probably need to count a week starting from my last Kratom dose to predict when the WD would be over, or could the hydro/oxy somehow maintain my dependence on it and might it be that the Kratom WD might not even start till I stopped taking the hydro/oxy?

And can I expect that my WD symptoms from one or both (Kratom and the traditional opioid) will feel like typical Kratom WD, or could it have aspects of oxy/hydro WD?

 

[Mycophile]

Anyone?

 

[daturetard]

I find that kratom blocks up my receptors (traditional opioids can't really attach) and it would be better to save the oxy/hyrdo for another time when you're off kratom, and take something targeted at sleep like ambien, Ativan, mirtazepine, clonidine, or even doxylamine or dph. Any drugs from most of these classes should do the trick.

 

[Mycophile]

Ok, so the doctor prescribed me really strong naproxen to lower inflammation in my neck and lidocaine patches for the pain. I just want to know: is it safe to take kratom and/or kratom extracts while on naproxen and lidocaine?

I mean, the naproxen is just a stronger version of Aleve, and I've taken Aleve with kratom and kratom extracts plenty of times, but not lidocaine.

I usually don't even take kratom but I have been lately cause of the pain and irritability, and even though I now have something else for the pain, lets be honest, I like the way Kratom feels.

Is Kratom an NSAID or blood thinner? Cause they say not to take naproxen with other blood thinners. I would THINK that it isn't really in the same way as aspirin, ibuprofen and naproxen, but I could be wrong.

Please let me know if this combination is safe.

 

[JackARoe]

I find that kratom blocks up my receptors (traditional opioids can't really attach) and it would be better to save the oxy/hyrdo for another time when you're off kratom, and take something targeted at sleep like ambien.

Yeah I have to be off kratom for at least a few days to even feel a moderate dose of oxycodone even though it is stronger. I learned that early on. I think it is simple tolerance and not antagonism like bupe. (just a guess) As long as I am using kratom nothing less than 50 mgs of oxycodone will be felt. Where as once kratom is out of the system the other pain meds work better. But yes it takes at least a few days off or even a week. Every once in a while I read about how some people balanced that out and alternate between the two with success. But kratom has helped me not use pills because they won't work without a few days break.

 

[Mycophile]

Yeah I have to be off kratom for at least a few days to even feel a moderate dose of oxycodone even though it is stronger. I learned that early on. I think it is simple tolerance and not antagonism like bupe. (just a guess) As long as I am using kratom nothing less than 50 mgs of oxycodone will be felt. Where as once kratom is out of the system the other pain meds work better. But yes it takes at least a few days off or even a week. Every once in a while I read about how some people balanced that out and alternate between the two with success. But kratom has helped me not use pills because they won't work without a few days break.

Could you please answer my other question from before?

Is it safe to take kratom powder and extracts while taking naproxen and using lidocaine patches? Could the kratom somehow negatively affect how the lidocaine metabolizes? Because that's something some people online said could happen but I don't know. And is kratom an NSAID?

I can avoid kratom most of the time that I'm on these drugs if necessary, but right now I'm pretty much definitely going to take an OPMS black shot because I just really want to and I'd planned on it, and then tonight hours after its worn off I'll be using a lidocaine patch and later I'll take naproxen.

Please let me know if there's issues with this.

Thanks

 

[daturetard]

Hey I get you need an answer but doing your own research in a situation like this I'd highly suggested. We do not know and it's a pretty unique situation to be in, it doesn't sound too bad but Naproxen is liver toxic as well as kratom..

 

[JackARoe]

Could you please answer my other question from before?

Is it safe to take kratom powder and extracts while taking naproxen and using lidocaine patches? Could the kratom somehow negatively affect how the lidocaine metabolizes? Because that's something some people online said could happen but I don't know. And is kratom an NSAID?

Well when I get sciatica I totally take naproxen or ibuprofen with kratom. That mix seems safe. I do not think kratom is a NSAID or a blood thinner. Lidocaine patches are probably safe too. I do not anticipate any negative interactions.

I feel it is safe to say in 2025 that kratom is fairly safe. Even with all these potent extracts (which I predict will lose popularity in time) we see very little issue. The media has not even put out a news article anytime recently about "killer kratom". (in 2006 that was common) There are not many issues. I think like cannabis you would have to hit someone over the head with a kilo to hurt them. Again all just my opinion.

 

[Mycophile]

Well when I get sciatica I totally take naproxen or ibuprofen with kratom. That mix seems safe. I do not think kratom is a NSAID or a blood thinner. Lidocaine patches are probably safe too. I do not anticipate any negative interactions.

I feel it is safe to say in 2025 that kratom is fairly safe. Even with all these potent extracts (which I predict will lose popularity in time) we see very little issue. The media has not even put out a news article anytime recently about "killer kratom". (in 2006 that was common) There are not many issues. I think like cannabis you would have to hit someone over the head with a kilo to hurt them. Again all just my opinion.

Yeah, it pissed me off how when I was doing a search on this an article by the Mayo Clinic came up called "Kratom: Unsafe and Ineffective." It proceeded to talk about the very few deaths associated with it and say other negative shit about it. I mean, generally speaking I hold the Mayo Clinic in high regards, but here I think whoever wrote that for them is either uninformed and/or has an agenda to push. Then again, the FDA is pushing a bullshit agenda so why wouldn't the Mayo Clinic?

Anyways, thanks. Also, I like to take edibles and vape weed for pain and just for fun, and it should be pretty unlikely that weed would have any kind of negative interaction with lidocaine, but just checking: there's no reason that an edible should interfere with the absorption of the patch right?

Also, with my Kratom I take potentiators like Turmeric, Curcumin, cayenne pepper and black seed oil. There's no reason those should mess with the lidocaine or Naproxen right?

 

[Mycophile]

Hey I get you need an answer but doing your own research in a situation like this I'd highly suggested. We do not know and it's a pretty unique situation to be in, it doesn't sound too bad but Naproxen is liver toxic as well as kratom..

Yeah, I did already do a search and couldn't find much so I wanted to ask a mod, and I got my answer.

You really think naproxen is TOXIC for the liver? I've never heard that. I mean, it puts a strain on it like just about all meds do in some way, but it's Tylenol that is actually really bad for the liver as far as I've heard. I've also never heard that Kratom is toxic for the liver. There are certain people who react badly to it, but most people are unaffected as far as their livers where Kratom is concerned. I think you are just talking about 2 things which put a little strain on the liver, but I don't think there's serious issues.

 

[JackARoe]

Yeah, it pissed me off how when I was doing a search on this an article by the Mayo Clinic came up called "Kratom: Unsafe and Ineffective." It proceeded to talk about the very few deaths associated with it and say other negative shit about it. I mean, generally speaking I hold the Mayo Clinic in high regards, but here I think whoever wrote that for them is either uninformed and/or has an agenda to push. Then again, the FDA is pushing a bullshit agenda so why wouldn't the Mayo Clinic?

Anyways, thanks. Also, I like to take edibles and vape weed for pain and just for fun, and it should be pretty unlikely that weed would have any kind of negative interaction with lidocaine, but just checking: there's no reason that an edible should interfere with the absorption of the patch right?

Also, with my Kratom I take potentiators like Turmeric, Curcumin, cayenne pepper and black seed oil. There's no reason those should mess with the lidocaine or Naproxen right?

Yes edibles would be safe with these combos. I am not seeing anything that is putting up a red flag in that post. I would take all of those at once and sometimes I do (except lidocaine patch but that should not be affected)

I would hope if anyone saw a danger here they would speak up. In fact I am sure they would. We have a lot of knowledgeable people here that would have spoken up.

Over the years one very endearing thing about you Myco is the caution you use moving forward. That is commendable. Better cautious than reckless.

I will say take the stuff with some food to protect the stomach. Some crackers and peanut butter mix well with kratom and all that other stuff in the stomach.

 

[Mycophile]

Yes edibles would be safe with these combos. I am not seeing anything that is putting up a red flag in that post. I would take all of those at once and sometimes I do (except lidocaine patch but that should not be affected)

I would hope if anyone saw a danger here they would speak up. In fact I am sure they would. We have a lot of knowledgeable people here that would have spoken up.

Over the years one very endearing thing about you Myco is the caution you use moving forward. That is commendable. Better cautious than reckless.

I will say take the stuff with some food to protect the stomach. Some crackers and peanut butter mix well with kratom and all that other stuff in the stomach.

Thanks for the compliment. I like to have fun like everyone else, but I do try to be careful.

Yeah, they made sure to tell me that I need to eat a FULL meal with the naproxen or I could get an ulcer. So I guess if it's time to take it then I have to force something substantial down even if I'm not hungry.

 

[daturetard]

You really think naproxen is TOXIC for the liver? I've never heard that. I mean, it puts a strain on it like just about all meds do in some way, but it's Tylenol that is actually really bad for the liver as far as I've heard. I've also never heard that Kratom is toxic for the liver.

Current research suggests both of these drugs are bad for your liver. Anything that 'strains' your liver, is liver toxic. It's just a kind way to put it. Think alcohol. Many toxins are safe in specific doses.

 

[Mycophile]

Current research suggests both of these drugs are bad for your liver. Anything that 'strains' your liver, is liver toxic. It's just a kind way to put it. Think alcohol. Many toxins are safe in specific doses.

I guess it's a matter of degree because there's nothing that the liver doesn't have to process. I very much doubt that Kratom or Naproxen are nearly as hard on your liver as alcohol or tylenol. I'm not generally concerned about mixing the two as there doesn't seem to be any serious contraindications.

 

[daturetard]

I guess it's a matter of degree because there's nothing that the liver doesn't have to process. I very much doubt that Kratom or Naproxen are nearly as hard on your liver as alcohol or tylenol. I'm not generally concerned about mixing the two as there doesn't seem to be any serious contraindications.

Yeah, I wouldn't say 'as bad as Tylenol or alcohol' but that's a low bar. There are definitely doses of each that would create equivalent toxicity, however.