Benzos Question about benzos, water solubility, and mucus membranes.

[StrangeOne23]

I'm always seeing that most benzos aren't absorbed through your mucous membrane in your nasal cavity because they aren't water soluble. Yet for some reason they say they can be absorbed through the membranes in your mouth. Where are people getting the idea that if something is water soluble it isn't absorbed through nasal mucous membranes? Is this just a common myth that has been spread so much it is now acted on like it is common knowledge or something? I'm not saying they are wrong but I have never once seen anyone post a source of this information to back it up. The fact that there are nasal spray formulations of some of these non water-soluble drugs seems to directly contradict what they are claiming. I know you can claim the formulations have things to aid their absorption but the claim being made is that it is IMPOSSIBLE for a water soluble drug to be absorbed through nasal mucous membranes. Please do not delete this thread saying it gets brought up all the time because I searched for quite a while and am unable to find an answer to my specific question. Thank you.

Also any links to studies involving any benzos and nasal bioavailability and/or onset would be greatly appreciated. There used to be one showing that some water soluble benzo actually had a higher bioavailibility when insufflated than oral from the University of Ky but I can no longer find it. I found a thread of someone saying that they posted a big thing of links in the past regarding this but it is no longer available. A lot of the older forum discussions are just gone.

 

[Las Veghost grower]

Mucus is not water so benzos likely have some solubility in mucus, just not a whole lot so it makes more sense to just eat them

 

[OpiateKiller]

I judge people who snort benzos

 

[StrangeOne23]

"
Mucus is not water so benzos likely have some solubility in mucus, just not a whole lot so it makes more sense to just eat them
"
Do you even need to dissolve the drug 1st for it to be able to pass through the membrane tho? Maybe the drug itself is capable of doing this, passing through the membrane without it dissolving? I've never seen any sources showing solubility necessarily has anything to do with it passing through a mucus membrane. I'm not saying it doesn't or that anyone is wrong, but I've never seen anyone back it up. Of course they do say it isn't absorbed.