Fertile
Bluelighter
- Joined
- Mar 31, 2022
- Messages
- 1,627
Hi,
I'm trying to figure out a test reagent that binds to a primary amine (so an aldehyde or ketone) that will produce a different colour depending on what is attached to the carbon (that is attached to the amine). I'm considering something like 3,3',5,5'-tetramethyl[1,1'-bi(cyclohexa-2,5-diene)]-4,4'-dione, 3,3'-dichloro[1,1'-bi(cyclohexa-2,5-diene)]-4,4'-dione, 3,3'-dimethoxy[1,1'-bi(cyclohexa-2,5-diene)]-4,4'-dione or even something asymmetrical.
The point is I am seeking a presumptive test that will provide a unique colour depending on what it is bound to. The electron shift due to the imine will alter the length of the double-bond between the two cyclohexa-1,4-diene rings.
The class of compound also has an (o-substituted) benzophenone moiety and the OBVIOUS choice is 2,4-dinitrophenylhydrazine which forms a yellow/orange solid but once again, I'm trying to figure out if their is some way to alter the C=N bond-length to imbue different colours.
Once I have it working I promise I WILL share it all, but suffice to say that it's very important in making a certain class of drug much safer because the user will know which member of the class it is. The problem is, you see, that some examples are 80-100 times more potent than others and so if you THINK you have the weak one... so you take 3 or 4, you end up unconscious for a day. Mix it with some other drugs and it REALLY is game over.
For those of you that don't know, pyrazolam was designed to be very safe in overdose. To this end, during testing I took 100mg (200 tablets) of the stuff. I slept for 5 days and was groggy for 2 more BUT I was OK. Now, if that had been something equipotent like flunitrazepam (Rohypnol), it would have been fatal. I had noted that 71% of intentional poisonings in Sweden were due to nitrazepam, flunitrazepam and clonazepam. Nitrobenzodiazepines are notably more toxic in overdose.
But this is another class, the benzoxazines. The only one people MAY have come across is etifoxine (Stresam) which isn't very potent BUT I've found enough patents and papers to build a QSAR and it's quite possible to produce an analogue some x100 more potent. For a start it's chiral so if you resolve the (S) isomer, it doubles the potency. 'o-(pseudo)halo reduces potency BUT replacing that 6-chloro with another moiety significantly increases activity. swap the N-ethyl for an N-(2-fluoroethyl) and it's a lot more active and swapping pendant aromatic from a benzene to a 3-pyridyl vastly increases potency. But basic hydrolysis yields a primary amine and a ketone and so I'm trying to use those to identify exactly which homologue a user has.
BTW I guess most people are not old enough but their is a sedative/hypnotic still used in China (and not explicitly controlled anywhere on the planet) - chlormezanone. You can swap the -Cl for a pseudohalogen but since it's made in vast quantities and is dirt cheap (and is well tested), I suggest people give it a try. I won't claim it's AMAZING, but it's better than temazepam, oxazepam and those related low-potency benzos.
I'm trying to figure out a test reagent that binds to a primary amine (so an aldehyde or ketone) that will produce a different colour depending on what is attached to the carbon (that is attached to the amine). I'm considering something like 3,3',5,5'-tetramethyl[1,1'-bi(cyclohexa-2,5-diene)]-4,4'-dione, 3,3'-dichloro[1,1'-bi(cyclohexa-2,5-diene)]-4,4'-dione, 3,3'-dimethoxy[1,1'-bi(cyclohexa-2,5-diene)]-4,4'-dione or even something asymmetrical.
The point is I am seeking a presumptive test that will provide a unique colour depending on what it is bound to. The electron shift due to the imine will alter the length of the double-bond between the two cyclohexa-1,4-diene rings.
The class of compound also has an (o-substituted) benzophenone moiety and the OBVIOUS choice is 2,4-dinitrophenylhydrazine which forms a yellow/orange solid but once again, I'm trying to figure out if their is some way to alter the C=N bond-length to imbue different colours.
Once I have it working I promise I WILL share it all, but suffice to say that it's very important in making a certain class of drug much safer because the user will know which member of the class it is. The problem is, you see, that some examples are 80-100 times more potent than others and so if you THINK you have the weak one... so you take 3 or 4, you end up unconscious for a day. Mix it with some other drugs and it REALLY is game over.
For those of you that don't know, pyrazolam was designed to be very safe in overdose. To this end, during testing I took 100mg (200 tablets) of the stuff. I slept for 5 days and was groggy for 2 more BUT I was OK. Now, if that had been something equipotent like flunitrazepam (Rohypnol), it would have been fatal. I had noted that 71% of intentional poisonings in Sweden were due to nitrazepam, flunitrazepam and clonazepam. Nitrobenzodiazepines are notably more toxic in overdose.
But this is another class, the benzoxazines. The only one people MAY have come across is etifoxine (Stresam) which isn't very potent BUT I've found enough patents and papers to build a QSAR and it's quite possible to produce an analogue some x100 more potent. For a start it's chiral so if you resolve the (S) isomer, it doubles the potency. 'o-(pseudo)halo reduces potency BUT replacing that 6-chloro with another moiety significantly increases activity. swap the N-ethyl for an N-(2-fluoroethyl) and it's a lot more active and swapping pendant aromatic from a benzene to a 3-pyridyl vastly increases potency. But basic hydrolysis yields a primary amine and a ketone and so I'm trying to use those to identify exactly which homologue a user has.
BTW I guess most people are not old enough but their is a sedative/hypnotic still used in China (and not explicitly controlled anywhere on the planet) - chlormezanone. You can swap the -Cl for a pseudohalogen but since it's made in vast quantities and is dirt cheap (and is well tested), I suggest people give it a try. I won't claim it's AMAZING, but it's better than temazepam, oxazepam and those related low-potency benzos.
