Poziotinib

[Zephyn]

Poziotinib​

It is built on an anilino-quinazoline scaffold and inhibits the epidermal growth factor receptors EGFR, HER2/neu, and Her 4[3] and binds covalently to its targets.[4]


I got fired from my job due to mostly drinking during work, indirectly, anyway, I am considering booking a flight to go have this experimental cancer drug tested on me in exchange for $10k.

Tried to put this in advanced drug discussion but anyway this is vastly past my rudimentary understanding of pharmacology. Wtf does this shit do exactly ?

 

[telepathetic]

I hope you don't get sick or die.

 

[Nagelfar]

I hope you don't get sick or die.

Please try to be more constructive with your concerns when taking the time to answer someone's query, or it just runs risking transgression of our community guideline with what can amount to personal abuse.

Candor can be appreciated when informative (esp. as the N&PD subforums tend toward imparting discussion of objective principles and be a safe place for NPOV approach of subject matter in a solely technical sense)

 

[Skorpio]

Poziotinib​

It is built on an anilino-quinazoline scaffold and inhibits the epidermal growth factor receptors EGFR, HER2/neu, and Her 4[3] and binds covalently to its targets.[4]


I got fired from my job due to mostly drinking during work, indirectly, anyway, I am considering booking a flight to go have this experimental cancer drug tested on me in exchange for $10k.

Tried to put this in advanced drug discussion but anyway this is vastly past my rudimentary understanding of pharmacology. Wtf does this shit do exactly ?

What kind of study is it (I'm assuming phase I due to the high pay).

Basically it is a fairly broad spectrum EGFR inhibitor with a covalent mechanism of action.

Epidermal growth factor receptors are tyrosine kinase receptors that can be inappropriately activated in certain cancers, sending growth signals when they should not be doing that. Blocking these receptors can be a way to pause the growth of cancer if it is driven by this pathway (often the receptors will mutate and a different approach will be needed).

This class of drugs seems to be known for producing skin side effects and some gi effects: (skin effects kind of make sense because it is epidermal growth factor)

Managing EGFR inhibitor side effects in lung cancer patients - Oncology Nurse Advisor

Epidermal growth factor receptor inhibitors are a mainstay of lung cancer treatment. Oncology nurses can do much to ensure their most effective use.

www.oncologynurseadvisor.com

The fact that the drug binds covalently means that it will have a much longer duration of action than drugs that associate and dissociate from the binding site of a protein. This drug will likely block egfrs for the life of the protein which could be in the timescale of weeks.

I am no doctor of course.
My opinion I have is that medical trials (I've done a few in my day) never overpay. I would be prepared for a fairly strenuous event.