Heroin Powder Heroin hydrolysis to 6-mam ?

[sicknesz]

Hi, SWIM read that heroin can be converted to the more potent 6-MAM, via a simple hydrolisis, where SWIM lives there's only Type 3 Heroin (or maybe 4 cause it doesnt really need acid to dissolve in water ? (diacetylmorphine hydrochloride ??) anyway what SWMI wanted to ask was, could he put his 1 gramms of poorly dosed powder heroin and convert the small amount of dope to 6-mam with a phosphate buffer (ph 6.4 / 7.4) solution ?? will it works ?? and how could he recrystallized it to a non-liquid form, or maybe he shall inject it that way ??? (guessing phosphate isn't vein friendly lol)

Source :
"Electron-capture gas-liquid chromatography was used to study the spontaneous hydrolysis of heroin in phosphate buffer (pH 6.4 and pH 7.4) at 23 degrees C. Aliquots of solution were taken over a 24-h period. After extraction at pH 8.9 into propan-2-ol (10%)-ethyl acetate, deacetylated products were made into hepafluorobutyrate derivatives which were analyzed quantitatively using nalorphine as the internal standard. Heroin decomposes to 06-monoacetylmorphine (06-MAM) under these conditions. Further decomposition to morphine was not observed. Spontaneous hydrolysis was faster at pH 7.4 (first-order rate constant, 9.6 x 10-5 min-1) than at pH 6.4 (first-order rate constant, 3.0 x 10-5 min-1). In 24 h, the decomposition to 06-MAM was 13 and 4%, respectively."

PMID: 688091 [PubMed - indexed for MEDLINE]

 

[phr]

First off, there's no need for swim.

Further decomposition to morphine was not observed.

That's surprising.

In 24 h, the decomposition to 06-MAM was 13 and 4%, respectively.

And that doesn't seem like a very good yield.


IMO, the effort and risk of bacterial growth isn't worth it. What's wrong with just leaving it as heroin?

 

[scottd420]

Does the body not metalbolize diacetylmorphine to 6-acetylmorphine anyhow? I'm just wondering about the goal of this experiment.

 

[Cane2theLeft]

^The body metabolizes diacetylmorphine to morphine.

 

[muvolution]

This is bordering on synthesis and we don't use SWIM.

I see no point in changing your Heroin to something else, it will either result in shorter duration, a less euphoric and more stupor-oriented high, and the possibility of fucking up your little lab experiment.
If you are thinking about anything like this, you should first try the method (posted many times, many places) for purifying street heroin to an injectable 99% USP solution.

 

[Cane2theLeft]

^You're right, this is synthesis discussion.

I wouldn't try to guess a process like this based on a couple sentences in a single abstract... furthermore, as others have said, this is likely to be ineffective and not worthwhile.