Stimulants Potentiating Vyvanse by increasing stomach pH?

[PsychedelicLove]

According to Wikipedia (I know, I know, Wikipedia is unreliable...): "The conversion of lisdexamphetamine to d-amphetamine is not affected by gastrointestinal pH and is unlikely to be affected by alterations in normal gastrointestinal transit times."

So...does this mean the old baking soda potentiation method won't work?

 

[ErgicMergic]

According to Wikipedia, that means that the breaking off of L-Lysine from the Lisdexamfetamine chain won't be affected by making your stomach less acidic with baking soda. This means that once the D-amp is in your system, baking soda will potentiate it by preventing elimination.

I was just about to reply after reading the thread title to suggest that the breaking off of L-Lysine probably needs normal stomach acidity to work, but who knows?

 

[Captain.Heroin]

Well answered Ergic.

 

[laCster]

the lisd-amp must be cleaved by the liver so that it can be absorbed. as a result, the amphetamine is not absorbed in the stomach, but rather in the first intestine after the lysine molecule is removed by liver enzymes.

in theory, changing the stomach pH will not affect the BA of vyvanse

 

[jlj5237]

Keeping stomach pH higher with tums or sodium bicarbonate might not affect absorption, but it will most likely cause the effects to last a bit longer since basic conditions cause you to excrete dexamp at a slower rate. Avoiding acidic foods and drinks throughout the day until the comedown will help as well.

 

[Trigeminal]

^actually wiki says its converted to d-amp by enzymes in red blood cells, which won't happen until AFTER it's absorbed.

OP, wiki says increased pH won't affect CONVERSION of vyvanse to d-amp, that doesn't mean that increased pH wont affect ABSORPTION of vyvnase, which is the prodrug.

Based on the structure of the molecule, and considering lysine is a basic amino acid, so the effect of pH won't be any different compared to d-amp, baking soda WILL increase absorption in the GI tract.

The point here is that conversion and absorption are two different concepts, just because increased pH won't affect conversion of vyvanse to d-amp (which happens in blood) doesn't mean increased pH won't increase absorption of vyvanse, which is the prodrug.

Increased absorption of vyvanse = increased d-amp.

The Lycine is NOT cleaved in the GI Tract, if that was the case, intranasal administration of the drug would not work.

 

[c0nzor]

High acidity helps break down the drug faster thus helping it hit faster and harder but decreasing its duration. So plenty of orange juice should get you your desired effects I should think.

 

[ErgicMergic]

^The increased rate of elimination is true, but acidic environments also decrease initial intestinal absorption. So, make sure it is totally absorbed before taking acids.

I've thought about this, and I'm not sure it "[helps] it hit faster and harder." That makes no sense, since Vitamin C doesn't increase your metabolism, it just decreases the amount reabsorbed through the renal system.

 

[cjb017]

I dont know if this information helps, but my doctor told me this and prescribes me 60 mg of vyvanse daily.

He told me that no matter what route of administration i take the vyvanse, it's not abuse-able. if i inject it, rail it, skin pop it or smoke it, it won't be any different than swallowing the pill. and any way you alter it to swallow it, it won't affect you differently than if you take it normal.

vyvanse is designed to not be abused and designed to make someone not be able to get high from using it in a way it wasn't designed for.

 

[cjb017]

he said that no one on the streets would want to buy my vyvanse because the public generally knows that vyvanse isn't abuseabe like ritalin or dexedrine.

most people i've met in vancouver knows that they can't get high from my vyvanse and they don't want any of it, which i'm glad they don't want it.

I highly doubt if you can't get high from injecting vyvanse any different from swallowing the pill, that adding vitamin c or acidic drinks will change its absorbancy.

 

[Trigeminal]

^The increased rate of elimination is true, but acidic environments also decrease initial intestinal absorption. So, make sure it is totally absorbed before taking acids.

I've thought about this, and I'm not sure it "[helps] it hit faster and harder." That makes no sense, since Vitamin C doesn't increase your metabolism, it just decreases the amount reabsorbed through the renal system.

I think he's assuming the enzymatic reaction that cleaves the lysine is acid-catalyzed. I haven't actually found any information regarding the mechanism of the cleavage, however. All I know is that it takes place in the blood.

 

[Tryptamino]

look up the trypsin method, that'll turn it into dextroamphetamine. not gonna go inot detail cause i guess thats a synthesis of some degree, which isnt allowed? not sure, but theres an old thread about it somewhere here

 

[~NaStYNaI~]

So generally how long does it take to feel the effects of vyvanse?