polyneuropharmacology; potentiation, synergism, augmentation, supplementation, Joy!

[streetsurfer]

Is it possibble that the next great advances in the treatment of mental illnesses will come from

There seems to be a growing number of people (myself included) who have combined traditionally contraindicated drugs with great success.

What about recreationally? Instead of going on a meth fuel weekend mix up the right doses of different pharmaceticals and possibbly get a better effect?

I would imagine there is the possibblity of some kind of interaction between two drugs that could cause an illness. Could a mixture of two benign substances become carcinagenic? What other mechinisms are there that long term damage could be caused that couldn't be redily hypothasised to happen?

I just invented the term polyneuropharmacology heh heh

 

[Tokey-tokerson]

huh? Um yes some drugs are synergetic.

 

[fastandbulbous]

I would imagine there is the possibblity of some kind of interaction between two drugs that could cause an illness. Could a mixture of two benign substances become carcinagenic

Like meth and salami? Salami & other cured meats contain sodium nitrite, which in combination with methamphetamine (or any secondary amine such as MDMA, ketamine etc) produce nitrosoamines which are known, potent carcinogens

 

[BilZ0r]

I don't consider going manic a great success.

How would polypharmacy be dangerous? By increasing the risk of pharmacokinetic and pharmacodynamic interactions. Whether this is an increased risk of tolerance/addiction/dependence or just overdose, or anywhere in between.

 

[nanobrain]

^^^^hm, i believe the term you just invented is 'polydrug abuse'...

with that in mind, there is much to be said for properly balanced supplementation w/neurotransmitter precursors, nootropics and nootropic doses of some of the many exotic phen / trypt derivs for mood augmentation, BLTC / transhumanist / Hedonistic Imperative style.

and if you are not intimately familiar with own neuropsychopharmacological / metabolic idiosyncracies, you could end up in a biosomatic shitcreek without the proverbial paddle, potentially making for the last ride. thoughts to ponder.

 

[indelibleface]

Like meth and salami? Salami & other cured meats contain sodium nitrite, which in combination with methamphetamine (or any secondary amine such as MDMA, ketamine etc) produce nitrosoamines which are known, potent carcinogens

Also, if you were so inclined, I guess in theory you could combine certain shampoos with salami, and produce nitrosamines as well (at least, any shampoo containing diethanolamines, like cocamide DEA). I remember there was a media scare a few years back in which nitrite contaminants in certain shampoo/conditioner products would react with the DEA ingredient and create nitrosamines.

And then, of course, the shampoo companies denied significant levels of the contaminant, a few of them switched to alternative ingredients, like cocamide MEA or PEA (phenethylamine?!), and everyone pretty much forgot about the whole thing.

 

[fastandbulbous]

Also, if you were so inclined, I guess in theory you could combine certain shampoos with salami, and produce nitrosamines as well

Not unless you've taken to drinking shampoo or using salami as a hair care product - used normally they never get a chance to get anywhere near each other

 

[nanobrain]

^or you are misguidedly using shampoo as a lubricant when playing 'hide the salami' or 'bury the sausage'?

 

[fastandbulbous]

^ Always somebody who has to decend into smut, isn't there?!

 

[moracca]

staying away from the bury the sausage venture, is cured meats + certain drugs a significant concern? ie, should one stay away from eating cured meats around the time he would be consuming drugs?

 

[nanobrain]

^working in the biomedical field and dealing w/bowel and stomach cancer patients all the time, i'll tell you this - y'all should hardly eat any cured meats, if at all, as there is a definite link w/nitrosamines and certain types of neoplasms.

nitrites used to preserve and flavouor meats tend to form nitosamines invivo anyhow, without the additional need for amphetamine or RCs.

your best bet is to, ahem, bury your hotdogs and salamis...in the back yard.

 

[Jamshyd]

LMAO @ Shampoo and Salami :D

On a more serious note, I have actually never heard of the nitrosamine risk with using secondary amine drugs. Interesting it has not been leeched on by the anti-drug media.

On the subject of polypharmacy though... I have reason to believe that taking Ketamine with any stimulants (that includes MDMA in my book) would reduce the incidence of hyperexcitable toxicity. Idiosyncracies aside, of course.