Plugging 100mg tramadol
- Thread starter Brocks360
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Carpetshark
Bluelighter
I would really advise against it. Dont get me wrong, im a huge fan of plugging anything that I cant imbibe anywhere else, but Tramadol? NaBrah.
Ive never had a good time on lots of tramadol like I did other opiates. It feels dirty, chemically saturated, and really gets into my head.
Id rather plug shots of Southern Comfort, Mountain Dew chaser lol.
Ive never had a good time on lots of tramadol like I did other opiates. It feels dirty, chemically saturated, and really gets into my head.
Id rather plug shots of Southern Comfort, Mountain Dew chaser lol.
PPE
Greenlighter
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izo
Bluelighter
Why do you want to plug tramadol? It needs to get metabolized in the liver…
CavernsoftheMind
Bluelighter
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- Nov 28, 2024
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You propably want to have as much of the Tramadol metabolized to O-Desmethyltramadol (which is way more euphoric & a stronger opioid than Tramadol itself), so oral is best for the First Pass effect metabolization.
If plugging / shooting Tramadol would work well, they'd put Naloxone in it like in Tilidin.
If plugging / shooting Tramadol would work well, they'd put Naloxone in it like in Tilidin.
DeathIndustrial88
Bluelighter
No, it needs your liver in order to metabolize into the active full agonist metabolite.
Really not much to add beyond some detail. The responses in this thread are bang-on.
Tramadol is mainly an SNRI, and plugging will highlight that aspect. Tramadol is a prodrug for O-desmethyltramadol, just as codeine is a prodrug for morphine. O-desmethyltramadol is formed by the cytochrome P450 2D6 enzyme in the liver, and is both more potent and selective as a mu opioid agonist than tramadol. In this case first-pass metabolism from oral administration is a boon, as you get an immediate hit of O-desmethyltramadol, rather than a biphasic shift from SNRI effects to opioid effects (with weaker overall opioid effects due to the lower area under the curve without first-pass metabolism).
Tramadol is mainly an SNRI, and plugging will highlight that aspect. Tramadol is a prodrug for O-desmethyltramadol, just as codeine is a prodrug for morphine. O-desmethyltramadol is formed by the cytochrome P450 2D6 enzyme in the liver, and is both more potent and selective as a mu opioid agonist than tramadol. In this case first-pass metabolism from oral administration is a boon, as you get an immediate hit of O-desmethyltramadol, rather than a biphasic shift from SNRI effects to opioid effects (with weaker overall opioid effects due to the lower area under the curve without first-pass metabolism).
PPE
Greenlighter
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- Jun 7, 2025
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By plugging, I was hoping to get relief faster (5min). But after plugging 100mg there was zero effect. I tried it a couple more time, but again no effect. So that’s when I decided to reach out to bluelight. Going forward, I will take 50mg orally and wait 30min, and take another 50mg. Thank you for your insight.
On a separate note, I’ve been plugging 200-300mg gabapentin. It helps me relax at end of day and then I take .25 Xanax to sleep. It’s very effective. And then in the morning I start my day with 10mg adderall. I think it’s safe I just hope I’m not taxing my liver.
On a separate note, I’ve been plugging 200-300mg gabapentin. It helps me relax at end of day and then I take .25 Xanax to sleep. It’s very effective. And then in the morning I start my day with 10mg adderall. I think it’s safe I just hope I’m not taxing my liver.