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Piperazine effects on ecstasy tolerance

Well, Piperazine's are a 5-HT1A receptor antagonist, and 1 week after a single administration of MDMA into a rat revealed that the 5-HT1A receptor density was increased by approximately 25-30%. Added to that, they both affect your serotonin and dopamine, so it's safe to say that Piperazine's DO have an affect on Ecstasy tolerance. Note though, that in the lab rat study, they gave the rats 30mg MDMA per 1kg of body weight - which is an extraordinarily high does for a rat.
 
K-Dazed said:
Well, Piperazine's are a 5-HT1A receptor antagonist, and 1 week after a single administration of MDMA into a rat revealed that the 5-HT1A receptor density was increased by approximately 25-30%. Added to that, they both affect your serotonin and dopamine, so it's safe to say that Piperazine's DO have an affect on Ecstasy tolerance. Note though, that in the lab rat study, they gave the rats 30mg MDMA per 1kg of body weight - which is an extraordinarily high does for a rat.
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This kid has no idea what he's talking about. The above paragraph is largely speculative and non-sensical, not to mention not helpful in any way to the OP's question.

AFAIK, the cross-tolerance of BZP/MDMA is not thoroughly studied (beyond anecdotal evidence -> though if I'm wrong, someone please correct me) and such non-scientific reports are hard to judge, since BZP and MDMA each build tolerances quickly in users, in addition to the subjective nature of drug experiences. If I had to hazard an educated guess, I would expect them to show some degree of cross-tolerance.

Interestingly, BZP has been shown to cause cross-sensitization with methamphetamine (Brennan K, Johnstone A, Fitzmaurice P, Lea R, Schenk S (2007). "Chronic benzylpiperazine (BZP) exposure produces behavioral sensitization and cross-sensitization to methamphetamine (MA)". Drug Alcohol Depend 88 (2-3): 204–13. doi:10.1016/j.drugalcdep.2006.10.016. PMID 17125936.) The paper referenced suggests BZP induces sensitization to strongly dompaminergic amphetamines. One could go as far as to speculate it could simultaneously build a tolerance for MDMA's SERT effects and simultaneously sensitize the DA system: like I said above - I don't think this is well-studied.
 
shulgin_jr said:
This kid has no idea what he's talking about. The above paragraph is largely speculative and non-sensical, not to mention not helpful in any way to the OP's question.

AFAIK, the cross-tolerance of BZP/MDMA is not thoroughly studied (beyond anecdotal evidence -> though if I'm wrong, someone please correct me) and such non-scientific reports are hard to judge, since BZP and MDMA each build tolerances quickly in users, in addition to the subjective nature of drug experiences. If I had to hazard an educated guess, I would expect them to show some degree of cross-tolerance.

Interestingly, BZP has been shown to cause cross-sensitization with methamphetamine (Brennan K, Johnstone A, Fitzmaurice P, Lea R, Schenk S (2007). "Chronic benzylpiperazine (BZP) exposure produces behavioral sensitization and cross-sensitization to methamphetamine (MA)". Drug Alcohol Depend 88 (2-3): 204–13. doi:10.1016/j.drugalcdep.2006.10.016. PMID 17125936.) The paper referenced suggests BZP induces sensitization to strongly dompaminergic amphetamines. One could go as far as to speculate it could simultaneously build a tolerance for MDMA's SERT effects and simultaneously sensitize the DA system: like I said above - I don't think this is well-studied.
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Interesting, thanks!
 
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