^^^^^^^Yeah you're probably right. MDMA does accelerate the release of serotonin - and speeds up many organ processes. its putting an extra LOAD on your brain and body... it should be expected that you may come across increased wear to whatever degree.
Apply it to something else - a combustion engine in a car for example - now turbocharge it. All of the engines internals and seals will be put under an additional strain - and depending on how hard the engine is worked (by it's driver...) a mechanic might expect to come across blown gaskets or worn piston bores earlier than a naturally aspirated engine.
carrying on with the analogy, if u burn around day after day, corner after corner, you're entire car is going to cop a battering! balding tyres, thinning brake pads.. a noisier valvetrain (now i like that metaphor

). but what would you expect? itd be hairy to think what would happen if you clipped a curb in your thrashings - it could be disasterous!
Now in terms of burning out on E, you will feel the wear. come downs usually become harsher. and push it hard enough for long enough and you will arrive at the feet of anxiety and depression.
The issue of neurotoxicity i think has truth - and from what ive read no one is sure on the extent of damage, its effects (long-term) and what doses bring it on. However, with responsible, irregular use incorporating appropriate pre-load and/or post-load regimes, i think we as humans do little damage. In the case of sad individuals like our spanish friend who ingests 2.5g in a session(8( !!!), i would say that the tall wave of neurotoxicity he experienced quite likely caused noticeable, irreversible brain damage.
However, regarding the many posts ive read where people claim heavy use has robbed them of their ability to concentrate, stay verbally coherent and retain information... In many cases (and im not saying ALL) these are symptoms of depression and anxiety and the inability to command ones own mind because of it.
I am only so strong in this view because it is what i have witnessed in mates and what i've personally experienced after 6 months of heavy E usage. I blamed my problems on brain damage caused by weed and mdma. It took me 4 months of not taking any ecstacy and weekly counselling to realise this was not the case and gain my self trust and confidence back.
In the long run - mdma may have an effect. I may get alzheimers 5 years earlier than i shouldve, my penis may fall off at teh base when i strike the age of 69 - woe is me. i believe in the quality not the quantity anyways
