Stimulants P2np -> DextroAmphetamine synthesis?

[LikeADaVinci]

Hi blue,

I’m interested to know: when reducing P2NP with something like sodium borohydride (NaBH4) is there any way to cause a preponderance of the dextra-amphetamine isomer to form over the racemic mixture? Is there some catalyst for example that will prefer the dextrose over the Levi isomer to form,

Thanks !!

 

[Skorpio]

Hey we don’t really do synth discussion here, but I’m pretty sure that asymmetric catalysts for reductive animation of amphetamines aren’t used in clandestine synthesis, as separation of isomers and re-isomerization of the undesired enantiomer is what gets reported by the DEA.