Regarding opioids & (over)excitation wikkepedia states that:
"Diacetylmorphine produces more euphoria than other opioids upon injection. One possible explanation is the presence of 6-monoacetylmorphine (6-MAM), a metabolite unique to diacetylmorphine."
Wikkepdia goes on to say that only for smoked or injected (perhaps due to the presence of heat applied to the powder) in turn giving off another by-product (a strong one too)...6-MAM.
I believe this chemical 6-MAM gives the unexplicable yet undoubtebly urge to smoke over the urge to snort, the fiendish aspect and for those who smoke a lot...that feeling in the top of your head/brain where yours brain cells are being tingley and massaged by endorphins which every 2-3hrs ask for another toke. Since snorting doesn't give the by-product of flame/heat....that should be a more traditional high in terms of relatively classic old school traditional narcotic (like morphine..a bit more synthethic feeling) rather than full on synthethic almost when smoked.
I am almost certain this happens when a person with a low tolerence starts using strong/er narcotics like morphine, oxy or heroin....well I cannot comment on IV use but snorted and/or smoked these narcotics simuntaneously (sp?) produce a state of sedation & stimulation..think of Kratom but in terms of coffee v.s. cocaine or methamphetamine type of difference for the newbies.
Anyways this person can use about 200mg even 300mg of heroin during a normal 24hr period, all this time smoking very high grade cannabis, taking benzos even drinking but NEVER going to sleep even though he/she is nodding out at times, these people become much more productive during this period much in the same way anyone using GHB experiences re-bound syndrome from releasing too many chemicals regulating stimulation such as dopamine.
In the case where the same person with low tolerence for opioids uses the 150mg-300mg heroin during the first couple days, by the 4-5th day the levels of heroin will have accumulated in the body to the point where your body has stored a bunch of metabolites, your brain cells have released tons of dopamine, endorphins, (serationin?..maybe)..anyways after a few days the usual levels/amounts of (6-MAM) you would be used to getting high now have little to no effect...hence why there is coined the term 'strung out' (running to get that same high back) something im sure occurs to smokers ESPECIALLY fentanyl smokers since fentanyl is shorter & more intense (this happens to Iv users too) is the tendency to start for example chasing a point or two in the morning when you wake up (1mg or 2mg if fentanyl) and since these 2 drugs are so powerful smoked most people even those experienced get hung up on the rush at the begining and start to forget about experiencing the opioid nod.
Instead experiencing the rush becomes number one objective and that person can and will do that for the entire day until he reaches levels of drugs so high in his blood causing his to go sleep for a good day or so after this happens. For example, a long time user I know brought over some fenanyl since he was used to H but not fentanyl so we chased it and smoked 5mg between us 2 with relatively low tolerence in around 30min and after every hit we would say we weren't high after we'd wait 1-3min....when the fentanyl ran out we realized we were chasing the high and how fuked we were my friend wasn't able to drive for shit taking him 30min for a 6min drive and going everywhere too.
A sidenote: fentanyl (a fully synthethic opioid) when chased is much more uplifiting and social than H however snorted H is actually sedating as fuck compared even to oral fentanyl.
"Diacetylmorphine produces more euphoria than other opioids upon injection. One possible explanation is the presence of 6-monoacetylmorphine (6-MAM), a metabolite unique to diacetylmorphine."
Wikkepdia goes on to say that only for smoked or injected (perhaps due to the presence of heat applied to the powder) in turn giving off another by-product (a strong one too)...6-MAM.
I believe this chemical 6-MAM gives the unexplicable yet undoubtebly urge to smoke over the urge to snort, the fiendish aspect and for those who smoke a lot...that feeling in the top of your head/brain where yours brain cells are being tingley and massaged by endorphins which every 2-3hrs ask for another toke. Since snorting doesn't give the by-product of flame/heat....that should be a more traditional high in terms of relatively classic old school traditional narcotic (like morphine..a bit more synthethic feeling) rather than full on synthethic almost when smoked.
I am almost certain this happens when a person with a low tolerence starts using strong/er narcotics like morphine, oxy or heroin....well I cannot comment on IV use but snorted and/or smoked these narcotics simuntaneously (sp?) produce a state of sedation & stimulation..think of Kratom but in terms of coffee v.s. cocaine or methamphetamine type of difference for the newbies.
Anyways this person can use about 200mg even 300mg of heroin during a normal 24hr period, all this time smoking very high grade cannabis, taking benzos even drinking but NEVER going to sleep even though he/she is nodding out at times, these people become much more productive during this period much in the same way anyone using GHB experiences re-bound syndrome from releasing too many chemicals regulating stimulation such as dopamine.
In the case where the same person with low tolerence for opioids uses the 150mg-300mg heroin during the first couple days, by the 4-5th day the levels of heroin will have accumulated in the body to the point where your body has stored a bunch of metabolites, your brain cells have released tons of dopamine, endorphins, (serationin?..maybe)..anyways after a few days the usual levels/amounts of (6-MAM) you would be used to getting high now have little to no effect...hence why there is coined the term 'strung out' (running to get that same high back) something im sure occurs to smokers ESPECIALLY fentanyl smokers since fentanyl is shorter & more intense (this happens to Iv users too) is the tendency to start for example chasing a point or two in the morning when you wake up (1mg or 2mg if fentanyl) and since these 2 drugs are so powerful smoked most people even those experienced get hung up on the rush at the begining and start to forget about experiencing the opioid nod.
Instead experiencing the rush becomes number one objective and that person can and will do that for the entire day until he reaches levels of drugs so high in his blood causing his to go sleep for a good day or so after this happens. For example, a long time user I know brought over some fenanyl since he was used to H but not fentanyl so we chased it and smoked 5mg between us 2 with relatively low tolerence in around 30min and after every hit we would say we weren't high after we'd wait 1-3min....when the fentanyl ran out we realized we were chasing the high and how fuked we were my friend wasn't able to drive for shit taking him 30min for a 6min drive and going everywhere too.
A sidenote: fentanyl (a fully synthethic opioid) when chased is much more uplifiting and social than H however snorted H is actually sedating as fuck compared even to oral fentanyl.
