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  • BDD Moderators: Keif’ Richards | negrogesic

Opioids Opioid/Tramadol

J

jerseyshark

Bluelighter
Joined
Jan 11, 2021
Messages
153
Location
Florida
What has been anyone's experience with percocet/ tramadol ? Is their any potentiation of the oxy from the percocet (20mg total/100 mg tramadol)?
 
There is a difference between "potency" and "synergy". If you take Tramadol and Oxycodone simultaneously, you will be receiving a higher total dose of Opioid agonists. This is as simple as adding factors together. We determine the strength of Tramadol relative to Oxycodone, this factor is:

100mg Tramadol = 6mg Oxycodone

A simplified but useful way of understanding this would be to say, "I'm taking 26mg Oxycodone" if you're trying to understand the broad strokes.

There are certain combinations of drugs that will produce "synergy". This is a term used to describe an end result greater than the sum of its parts, if you will.

If I drink 6 Alcoholic drinks and combine that with 2mg Alprazolam (Xanax) for instance, you're going to end up with an effect greater than what you would have had you taken them separately. This is part of why we are so cautious regarding combinations of different Central Nervous System depressants.

Your situation is different. If you want to take more Opioids, you can take more Opioids and the end result will be pretty much what you would expect.
 
Really wouldn't recommend you do this, when I was addicted to opiates i stupidly started having tramadol alongside Dihydrocodeine As in the same day, delaying the dose wont lower seizure risks by much) , and i had a bunch of seizures during that time and traumatised my family. and it wasn't even enjoyable to be honest. Tramadol ruins the opiate, with its weird speedy effects and its a bit frightening knowing you could have a seizure at any moment. Not at all worth it, risking your life for a really crappy buzz. Tramadol in general shouldn't be used alongside anything, the risk of a seizure isn't a good trade off in my opinion.
 
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FowardMoving said:
Not at all worth it, risking your life for a really crappy buzz. Tramadol in general shouldn't be used alongside anything, the risk of a seizure isn't a good trade off in my opinion.
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And it's slow as fuck to come up on.
jerseyshark said:
How separately? An hour? 2? 30 min?
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I mean like a day at least. They won't have better effects than just taking another 5mg oxy
 
Keif' Richards said:
There is a difference between "potency" and "synergy". If you take Tramadol and Oxycodone simultaneously, you will be receiving a higher total dose of Opioid agonists. This is as simple as adding factors together. We determine the strength of Tramadol relative to Oxycodone, this factor is:

100mg Tramadol = 6mg Oxycodone

A simplified but useful way of understanding this would be to say, "I'm taking 26mg Oxycodone" if you're trying to understand the broad strokes.

There are certain combinations of drugs that will produce "synergy". This is a term used to describe an end result greater than the sum of its parts, if you will.

If I drink 6 Alcoholic drinks and combine that with 2mg Alprazolam (Xanax) for instance, you're going to end up with an effect greater than what you would have had you taken them separately. This is part of why we are so cautious regarding combinations of different Central Nervous System depressants.

Your situation is different. If you want to take more Opioids, you can take more Opioids and the end result will be pretty much what you would expect.
Click to expand...
Thank you Keif. My oxycodone from my pain doc has been reduced and, now I can't obtain mallinkrodt brand which worked well on my back. I can only obtain Rhodes pharma oxycodone which is like taking tylenol unless I take more and chew them, so, I'm looking for "synergy" by finding out if tramadol would help my synergy/reduce my oxycodone use. I've heard M3 , 30mg codeine works very well for synergy when taking after oxycodone, but, I don't know how long after taking oxy it would produce synergy or if one 30mg M3 or 2 pills taking after previously ingesting 20mg of oxycodone, say, two hours earlier. My goal is to reduce my oxycodone use because I'm running out a week early since taking Rhodes pharma. I live in se FL and 99.9% of all pharmacys want cash for opioids, not insurance, AND, they want $250-$575 for 90 15 mg oxycodone mallinkrodt pills. I've traveled to pharmacys all over S FL to hear "we don't accept new pain patients, we only get so many oxys each month and we're out, we don't sell to people who don't live in our county, etc etc etc. SO, I finally went to Publix supermarket and they accepted me to fill my oxys, but with these shit Rhodes. I know they 15mg Rhodes must conform to U.S. standards, which i believe is 13mg of active oxy in a 15mg pill, or 11mg, same as mallinkrodt brand, but there is no comparison in pain reduction between the two. Thus, my question to get synergy. Any other ways to maximize the synergy of oxycodone pills? To be able to take fewer, but enhance results? If you ask mod could provide me and the community some proven suggestions, I and the community would be most thankful. Everything you helped me with on bluelight before has been very useful information, and i respect your responses, and thank you for all your help! Your very knowledgeable! Please share any synergy tips to enhance/but perhaps reduce oxycodone use with the community. I tips my hat to you good sir! JS :)
 
My personal experience is the opposite of everyone's here.

I've never tried the combo with oxy, but I've had plenty of experience with tramadol + hydrocodone and tramadol + buprenorphine.
I think it synergizes nicely with both hydros & bupe. But how you'll react to tramadol is all dependent on your own bodily chemistry.

Some people don't have the right liver enzymes to convert tramadol in the liver to o-desmethyltramadol, which is a decent full agonist opioid. So those people are going to find tramadol very crappy. So will people with enormous tolerances. The parent drug (the tramadol itself) is only a shitty partial agonist. So if you lack the right enzymes, you won't get the full agonist metabolite's effects.

But if you're some one with no to low tolerance, adding tramadol to your oxy will just potentiate the opioid effect.

100mg of tramadol is a pretty low-standard dose too. I don't think you're gonna get any of the common side effects from 100mg.

The SNRI effects of tramadol are way over exaggerated. It's an incredibly WEAK SNRI, almost indistinguishable. Tramadol is also a TAAR1 agonist, which means it releases serotonin similar to drugs like methamphetamine, MDMA, albeit MUCH MUCH weaker than the latter mentioned drugs. But these qualities of tramadol do give it it's unique effects.

The seizure risk is only really an issue if you go above 400mg a day, so keep your doses lower than that & you shouldn't have too much of a problem.

The best way to take tramadol is stack your doses. Take 50mg and wait an hour & then take the other 50mg. Your body converts more of the following dose into o-desmethyltramadol once you already have some tramadol in your system. Taking it all at once will result in more of the SNRI/speedy effects hitting you all at once.

And yes tramadol takes about an hour & a half to come up, but it's effects can last up to 8hrs, unlike hydrocodone or oxycodone. And for those with really low tolerance, it's effects can last into the next day.

My experience comes from 11 years of being super addicted/dependent on tramadol & researching it's pharmacology. It is a bit of a dirty drug, but for me it was just as enjoyable as other opioids. It had this way of completely eliminating my boredom & made music sound absolutely wonderful. I would sit & nod & listen to music over & over on tramadol & never got bored. It gave me motivation to do things like get up & clean or take a long walk & I would actually enjoy myself while doing those things. When normally I'd be achey & irritated having to do those things. It's a wonderful drug for depression.

It's not very "potent", but potency has nothing to do with how enjoyable the effects will be. It's just a measurement of how much of a drug it takes to illicit an effect.
For example, buprenorphine is like 40x more "potent" than heroin/morphine, but it's not more enjoyable or better heroin. Fentanyl is more potent than heroin, but fentanyl's effects are no where near as enjoyable as heroin's.

Tramadol withdrawals are no joke though either. I went through tramadol withdrawal every month from the ages of 19-30. And every time, it had me completely unable to function & very suicidal & miserable until I could get the following months script. If it wasn't a decent opioid, none of that would have happened to me.

I'd take 300mg of tramadol over 10-20mg of hydro/oxycodone any time.
 
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DeathIndustrial88 said:
My personal experience is the opposite of everyone's here.

I've never tried the combo with oxy, but I've had plenty of experience with tramadol + hydrocodone and tramadol + buprenorphine.
I think it synergizes nicely with both hydros & bupe. But how you'll react to tramadol is all dependent on your own bodily chemistry.

Some people don't have the right liver enzymes to convert tramadol in the liver to o-desmethyltramadol, which is a decent full agonist opioid. So those people are going to find tramadol very crappy. So will people with enormous tolerances. The parent drug (the tramadol itself) is only a shitty partial agonist. So if you lack the right enzymes, you won't get the full agonist metabolite's effects.

But if you're some one with no to low tolerance, adding tramadol to your oxy will just potentiate the opioid effect.

100mg of tramadol is a pretty low-standard dose too. I don't think you're gonna get any of the common side effects from 100mg.

The SNRI effects of tramadol are way over exaggerated. It's an incredibly WEAK SNRI, almost indistinguishable. Tramadol is also a TAAR1 agonist, which means it releases serotonin similar to drugs like methamphetamine, MDMA, albeit MUCH MUCH weaker than the latter mentioned drugs. But these qualities of tramadol do give it it's unique effects.

The seizure risk is only really an issue if you go above 400mg a day, so keep your doses lower than that & you shouldn't have too much of a problem.

The best way to take tramadol is stack your doses. Take 50mg and wait an hour & then take the other 50mg. Your body converts more of the following dose into o-desmethyltramadol once you already have some tramadol in your system. Taking it all at once will result in more of the SNRI/speedy effects hitting you all at once.

And yes tramadol takes about an hour & a half to come up, but it's effects can last up to 8hrs, unlike hydrocodone or oxycodone. And for those with really low tolerance, it's effects can last into the next day.

My experience comes from 11 years of being super addicted/dependent on tramadol & researching it's pharmacology. It is a bit of a dirty drug, but for me it was just as enjoyable as other opioids. It had this way of completely eliminating my boredom & made music sound absolutely wonderful. I would sit & nod & listen to music over & over on tramadol & never got bored. It gave me motivation to do things like get up & clean or take a long walk & I would actually enjoy myself while doing those things. When normally I'd be achey & irritated having to do those things. It's a wonderful drug for depression.

It's not very "potent", but potency has nothing to do with how enjoyable the effects will be. It's just a measurement of how much of a drug it takes to illicit an effect.
For example, buprenorphine is like 40x more "potent" than heroin/morphine, but it's not more enjoyable or better heroin. Fentanyl is more potent than heroin, but fentanyl's effects are no where near as enjoyable as heroin's.

Tramadol withdrawals are no joke though either. I went through tramadol withdrawal every month from the ages of 19-30. And every time, it had me completely unable to function & very suicidal & miserable until I could get the following months script. If it wasn't a decent opioid, none of that would have happened to me.

I'd take 300mg of tramadol over 10-20mg of hydro/oxycodone any time.
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Thank you the for such awesome information! JS
 
If u are able to metabolize tramadol into M1 metabolite, it Is actually more potent MOR agonist than oxycodone. It just take more time for effects to start but they also lasts 2-3x longer. And monoaminergic effects of tramadol are crazy strong but affinity Is described as very weak. IT Is actually SNRI + serotonine releaser+ dopamine raising agent ( caused by Its effects on opioid receptors ).
 
WellTram said:
If u are able to metabolize tramadol into M1 metabolite, it Is actually more potent MOR agonist than oxycodone. It just take more time for effects to start but they also lasts 2-3x longer. And monoaminergic effects of tramadol are crazy strong but affinity Is described as very weak. IT Is actually SNRI + serotonine releaser+ dopamine raising agent ( caused by Its effects on opioid receptors ).
Click to expand...
Thank you WT.JS
 
may be the brand i get is absolute crap(tram)...but cannot feel any pleasure from 300,400 or 500mg....does not matter how much i take.....but it has pain relieving properties.....that's why i take it...a lot of broken and injured parts in my body
 
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I have an upcoming surgery and speaking with the nurse I found out the Dr will prescribe Tramadol for daytime use and Norco for bedtime in the first couple weeks. I'm very nervous about taking these together, but evidently this Dr thinks this is a way to decrease the Norco use. Should I be worried?
 
kris66 said:
I have an upcoming surgery and speaking with the nurse I found out the Dr will prescribe Tramadol for daytime use and Norco for bedtime in the first couple weeks. I'm very nervous about taking these together, but evidently this Dr thinks this is a way to decrease the Norco use. Should I be worried?
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Worried about what? Tramadol is fine for daytime, with its speedy attributes. Norco? You mean oxys? Or hydros? What are we talking about? Either way, no, you have nothing to worry about. I'm assuming your a seasoned user of opiates. Yes, your doc could use Tramadol to reduce the Norco consumption
 
I assume she meant hydrocodone. I've never had Tramadol before. I was thinking about the possibility of Serotonin Syndrome.

I've had a problem with hydrocodone in the past but I've been off it for awhile now but I'd still rather take something I'm use to and know how I respond to it.

Thanks.
 
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