Opioids Opioid stacking

[fairnymph]

When you mixe stuff, you are always increasing the risk over and above a simple addative mix.

Tapentadol is an odd one. I looked into it and while it'a MOR affinity is low, it appears to act as a SUPERaconist i.e. it activates the site more then the body's endogenous opioids.

It appears the nitazenes are both potent AND are superagonists so I foresee a major problem for anyone who becomes physically dependent i.e. there is no dose of methadone or buprenorphine that will fully substitute. I hate to say it but to me, nitazenes seem like a one way street. I mean, FANTASTIC for the dealers but very bad for the consumers.

But with nitazenes and fentanyl analogues on the market, nobody could compete on price. Someone COULD produce an alternative that was much better subjectively (and there are still some examples that are quite potent i.e. x80 M) but we are seeing Grisham's law played out in the most tragic manner.

Take care ofr yourself, man!

I’ve read some really gnarly posts on Dread about people who are using crazy high doses of nitazenes (so high I’m surprised they’re alive; they clearly worked up a mega tolerance over time) and searching for ever stronger ones because nothing else cuts it just like you. These are people who claim to actually prefer them and see them out though, so I don’t really pity them. But still - alarming. And the withdrawals are far worse than from any other type of opioid. I’ve had a taste of that myself from what’s in European h.

 

[fairnymph]

To answer the OP, I have rarely combined opiates/opioids because I try not to combine drugs in general and especially not downers. The withdrawal is always worse from multiple opioid compounds than just a single one. This is part of why poppy pod tea has such brutal withdrawals. I do not use for fun but for pain so I can’t report on any recreational effects, but I have not found any synergistic increase in pain relief from combining opiates. Just more side-effects. I’d avoid just stick to oxy, and consider other ways to lower your dose/tolerance. I find ketamine as an NMDA antagonist quite useful in this regard, and cimetidine also has notable potentiation. But be careful with cimetidine because the withdrawal from it can be unpleasant if you’re also withdrawing from an opiate (severe stomach pain); wait until you’re off the opiate before withdrawing from it.

 

[Keif' Richards]

Everything within my personal experience with these drugs and what I've read tells me that this effect is not "synergy", it's just taking more Opioids. There isn't any mechanism in Codeine that should increase the potency of Oxycodone or vice versa. It doesn't work that way. If you're just trying to get a more potent effect, just take them both at the same time, as there is no advantage to this split-dosing you're describing.