Can benzos be antagonistic? I.e. is it always ok to mix & match (at safe dosages)??
NSFW:
Many of us know that the various opioid drugs have relatively greater and lesser affinities for the opioid receptors in the brain (and elsewhere). For example, methadone has greater affinity than morphine or oxycodone, so if you take lots of morphine and oxycodone you would want to keep the methadone dosage low. This is slightly antagonistic. Buprenorphine is more antagonistic, narcan and naltrexone even more so.
Oxycodone and hydrocodone are basically additive. Take 'em apart, take 'em together, just take 'em.
Benzos and opioids are usually synergistic. Two plus two equals more than four.
Not sure if any opioid combos are synergistic (maybe fentanyl or ultram).
HERE'S MY MAIN QUESTION:
There are certainly benzodiazepine anatagonists that will bring you back from an OD: flumazenil being the most famous (don't take this if you happen to steal from your neighborhood pharmacy).
So, it follows that there are some benzos that are "better" at binding to the benzo receptor sites than others. If that were true, then you wouldn't want to take more than one type of benzo at a time.
I'm particularly wondering about phenazepam's -- I'm sure no one knows whether it has greater/lesser affinity -- ability to blockade/antagonize, say, xanax or clonazepam.
Anyone know? Thoughts, ideas?
In other words: one benzo at a time, or cocktails?
