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Opiates and brain deficits

achey node

Greenlighter
Joined
Jan 24, 2014
Messages
6
The received wisdom for the past decade was that opiates DONT cause brain damage. How this myth has been perpetuated for so long is beyond me however. Clinical trial after clinical trial has found apoptosis, hippocampal neurogenic retardatoin, grey matter thinning and hypoxic brain cell death. The end result of this is deficits to attention span learning memory and emotional well being.

Even if one were to pursue an actively healthy lifestyle how can one recover lost growth. From 17-25 there is a period of compensatory growth and peak performance is said to be attained at 22 persisting for a further 5 years. Most opiate addicts begin the addictive cycle at around 16. I personally began at 17 and at 22 am yet to quit. I have aspergers which has inexplicably gone from reasonably mild to severe in the past few years and I mourn the loss of the "golden years" during which I should have matured and rounded out my neurological development

Ive seen many attempts to wave away the numerous studies of grey,white matter ltp of synapses apoptosis neurogenic retardation etc. The most common rationalisation would be " Burroughs/Howard Hughes used opiates so the junkie lifestyle must be at fault".
However not only is there little quantitative data on their usage (though anecdotal reports abound) many studies have been conducted in rats which would neatly sidestep that particular argument. Additionally in most cases opiate addiction tends to result in diminished productivity. Coleridge Taylor may have published Kubla Khan while in the throes of an opium habit, but towards the end of his life his work never reached former glories. Given the magnitude of his genius his later work is still superior but its widely acknowledged that he never reached his full potential. This is probably the most commonly levelled charge made at opiate addicts

The romantic image of the troubled genius afflicted with an opiate habit has seeped into the consciousness of junkies everywhere. This has happened to the extent that people believe that opiates are totally harmless "prohibition is at fault". This attitude led to me continuiong my opiate use for over half a decade. If I had access to the studies and reports that I have posted here I would have discontinued my usage years upon years ago - my life would have been substantially different. As it is I have to come to terms with the fact that I may have lost potential that I might never regain. Add aspergers/ocd to my opiate habit and the last 7 years of my life have been riddled with self harm meltdowns and suicide. Intellectually im still capable but there are a quintillion subtle signs which convince me that I may have caused myself permanent harm

Im a new member so I dont want to seem presumptuous but I think that there needs to be a sticky with studies relating to this issue. Opiates aren't associated with cognitive deficits in the same way that amphetamines are - perhaps for good reason. Nevertheless, they are undeniably and directly neurotoxic. This fact needs to become more widely known.


Stage 3: 7 to 22 years

  • The neural connections or ‘grey’ matter is still pruning, wiring of brain still in progress, the fatty tissues surrounding neurons or ‘white’ matter increase and assist with speeding up electrical impulses and stabilize connections. The prefrontal cortex is the last to mature and it involves the control of impulses and decision-making.
  • Therefore, teenagers need to learn to control reckless, irrational and irritable behavior. Avoiding drugs, alcohol, smoking, unprotected sex and substance abuse.
798px-Human_Brain_Development_Timeline_Image.jpg



http://www.ncbi.nlm.nih.gov/pubmed/10840056
Chronic administration of morphine decreased neurogenesis by 42% in the adult rat hippocampal granule cell layer. A similar effect was seen in rats after chronic self-administration of heroin.

http://www.ncbi.nlm.nih.gov/pubmed/16369836
This study reports that opiate-dependent subjects have gray matter density decreases in prefrontal and temporal cortex, which may be associated with behavioral and neuropsychological dysfunction in opiate-dependent subjects.

http://pediatrics.uchicago.edu/chiefs/documents/morphine_and_apoptosis.pdf
we demonstrated that morphine markedly increased apoptosis of microglia and neurons via a cas-pase-3-dependent pathway.

http://journals.lww.com/neuroreport...rked_decrease_of_immunolabelled_68_kDa.3.aspx
NEUROFILAMENT (NF) proteins, the major components of the neuronal cytoskeleton, have been shown to represent previously unknown targets for the chronic effects of morphine in rats

http://academicpublishingplatforms....gnitive_impairments_at_various_pp.108-114.pdf
Torpid thinking (apathetic mindset), poor imagination, lack of capability to generalize and single out the key point can be specified as the OA-associated cognitive deficits. Memory defects, problems with attention concentration, incapability to follow subject-matter of a conversation, high distractibility and attention switching ability are frequently registered. Defective operative and short-term memory as well as low motivational activity can be specified as typical manifestations. Heroin affects formation of complex inductive inferences, visual-spatial coordination, understanding of logical-grammatical relations, spatial analysis and synthesis; disorders of visual memory, tactile perception and praxis being registered as well

http://www.jneurosci.org/content/22/5/1914.long
Our results revealed that chronic exposure of rats to morphine or heroin, which induced severe drug tolerance and dependence, markedly reduced the capacity of hippocampal CA1 LTP during the period of drug withdrawal (from approximately 190% in control to approximately 120%

http://www.ncbi.nlm.nih.gov/pubmed/...=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP
These findings demonstrated that chronic opiate treatment can significantly modulate synaptic plasticity in the hippocampus, leading to an opiate dependence of the plasticity.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC16588/?tool=pubmed
rats chronically exposed to morphine show impaired acquisition of reference memory (5). Such findings suggest that long-term opiate use may produce maladaptive plasticity in brain structures involved in learning and memory, such as the hippocampus.
 
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Great post, I would actually like to see/hear more about this topic from other opiate users or former users. As a former opiate addict who used heavily everyday for two years and every now and then for a year before that it would be interesting to read more about what long term damage I might have caused. I've been off them for a little over a year now and can definitely tell my brain still isn't "firing" like it use to before the use.
Thanks for am awesome post.
 
I guess its a good thing I was already 25 when I began to develop my opiate addiction. though I am sure the 100s of binge drinking episodes and smoking of marijuana multiple times daily for 8 years had some effect on my brain development. Btw one those things is legal and the other is getting really close to being so.

I do agree that opiates have some neurotoxic effects. Maybe not so much the parent drugs but the metabolites can be harmful when they are constantly flowing in the blood stream. Its the metabolites, the glucuronides to be precise, that seem to be the most toxic.
 
I haven't looked into the research, but finding changes in an fMRI isn't the same as actual deficits.
 
Where does Buprenorphine fit into this? I shudder to think... Year of heroin abuse have done enough cognitive damage, and being back on bupe, the only promising sign I see is the eyes dont get so dark, u dont look so sick on bupe, so maybe just better for the liver/kidneys? Think it's liver.

Guys, what'ya know?
 
Where does Buprenorphine fit into this? I shudder to think... Year of heroin abuse have done enough cognitive damage, and being back on bupe, the only promising sign I see is the eyes dont get so dark, u dont look so sick on bupe, so maybe just better for the liver/kidneys? Think it's liver.

Guys, what'ya know?

What do you mean about liver and kidneys? Opiates have never been shown to be toxic to those organs. As far as bupe goes it is an opiate, plain and simple.
 
What do you mean about liver and kidneys? Opiates have never been shown to be toxic to those organs. As far as bupe goes it is an opiate, plain and simple.

I'm referring to the amount of strain they put on the liver. I know when I do dope my eyes get dark. bupreorphine doesn't have this effect. I'm starting a conversation- it's not plain and simple. Buprenorphine is an oddball- I have no sources to back up this asssertion : P
 
well i was a long time user/addict of opiates(oxy,heroin,methadone) but have been clean from thenm for 6-7 years..the biggest problems i have noticed from my opiate use are the following

1-anhedonia, persistent low lying anhedonia is present i my life..exercise and medication only help to a very small degree..

2-lack of 'get up and go'..lack of motivation is also a problem..low energy too

3-i seem to have memory problems, difficulty concentrating but the major problems i have noticed are the above 2 symptoms..tbh i have thought about going back on some opiate maintanence treatment just to feel normal again..
 
Again, opiates aren't known to adversely affect or strain the liver at all.
The APAP from pills certainly can, but opiates do not


Holy Toast, this is off a manufacturers website-

Buprenorphine HCl sublingual tablets may cause
liver problems.
Call your doctor right away if:
• Your skin or the white part of your eyes turns yellow
(jaundice).
• Your urine turns dark.
• Your bowel movements (stools) turn light in color.
• You don’t feel like eating much food for several days or
longer.
• You feel sick to your stomach (nausea).
• You have lower stomach pain.
Your doctor will do blood tests while you are taking
buprenorphine HCl sublingual tablets to make sure
your liver is okay.
• Buprenorphine HCl sublingual tablets can cause
your blood pressure to drop. This can make you feel
dizzy if you get up too fast from sitting or lying down.
• Buprenorphine HCl sublingual tablets can cause
allergic reactions that can make it hard for you to
breathe. Other symptoms of a bad allergic reaction
include hives, swelling of your face, asthma (wheezing)
or shock (loss of blood pressure and consciousness).
Call a doctor or get emergency help right away if you
get any of these symptoms.

Thanks for the input Belfort
 
^np, what are some good opiate addiction websites?ive tried google but dont come up with much but id like to hear from more long term users of opiates, problems they encountered.
 
Harm Reduction Advice

^np, what are some good opiate addiction websites?ive tried google but dont come up with much but id like to hear from more long term users of opiates, problems they encountered.

Belfort- Addictionsurvivors is one I've seen come up numerous times I'm looking for facts or anecdotes.

I wonder how much the reduction in 02 and from high dose opioid-induced respiratory depression affects these changes in the brain.
I get so sad and angry every time I hear about someone ODing and their friends just slapping them or whatever else else, instead of giving rescue breathing "My friends will think I'm gay if I give mouth mouth". You could protect them from brain and organ damage. If you are hanging with high risk users, I Highly Recommend carrying around a rubber glove with the thumb cut off- perfect barrier for mouth to mouth recussitations.
 
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Where does Buprenorphine fit into this? I shudder to think... Year of heroin abuse have done enough cognitive damage, and being back on bupe, the only promising sign I see is the eyes dont get so dark, u dont look so sick on bupe, so maybe just better for the liver/kidneys? Think it's liver.

Guys, what'ya know?

What exactly are your referring to by dark eyes? Around the outside, like what people call baggy eyes, which is probably a result of poor sleep and lack of a proper nutritional diet associated with opiate addiction. Not something I would associate directly to liver or kidney damage.

Or do you mean the sclera? Which if they are jaundiced and dark from that, then it is probably a sign of liver damage. But I have never heard opiate abuse causing that. Maybe Hep C which is associated with heroin use, but the drug itself does not cause that.

Belfort- Addictionsurvivors is one I've seen come up numerous times I'm looking for facts or anecdotes.

I wonder how much the reduction in 02 and from high dose opioid-induced respiratory depression affects these changes in the brain.
I get so sad and angry every time I hear about someone ODing and their friends just slapping them or whatever else else, instead of giving rescue breathing "My friends will think I'm gay if I give mouth mouth". You could protect them from brain and organ damage. If you are hanging with high risk users, I Highly Recommend carrying around a rubber glove with the thumb cut off- perfect barrier for mouth to mouth recussitations.

Could even go as far as to buy a pocket CPR mask. They are no more than $10. Sure might be tough to carry it around everywhere, but maybe keep one in your car or if there is a place you do the majority or your using, then keep it there. Car is good because it is going to be with you and not too far away the majority of the time. I actually have one in my car, mainly because I am an EMT and I work details on the side for youth football. So I need to have a small bag of equipment to deal with injuries and the possible medial emergency. I gotta score me a vial of narcan and an atomizer someday, then I'll be all set for any ODs. Of course having Narcan around is a good idea, too.

It is really sad the things people do when someone falls out, instead of rescue breaths. As an EMT I tell you almost everyone throws water on the person, and I just shake my head. That seems to be the go to move. It seems the most likely time a person is being given CPR its by some random person(s) who found them. I do not advocate for mouth to mouth in these situations, and lay person CPR calls for compression only in the case of an unresponsive person, no pulse check is called for. The friends and family seem most likely to just do pointless things like throw water on them, shake them violently, yell at them and just panic.
 
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Right on RTrain! I guessed you were in the field, from the tone of your writing : ) As you may have suspected I'm also an EMT, thinking about working in an ER as a Tech or nurse.

I notice heroin use causes bags around my eyes that are independent of nutritional or other external factors. I quite health conscious, mak sure to keep the bowels moving when using, eat organic high nutrient foods, when I'm not juicing.

I've been thinking about getting scripted a mini 02 tank, to go along with my modest go-bag. Becuase I they are disposable I don't think I want to repeatedly spend the money on cpr masks, though I'll probaby waste money on one anyway :D I'm a sucker for gizmos and gandgets...

I haven't found many ears willing to take seriously the consequences of opiate addiction. I can't be friends with people who refuse to listen to common sense advice that could protect another from harm : ( Good bye old friends!

I have a few vials of Narcan, though luckily I haven't had to use em yet! Haven't had any luck giving em away either...

PS I don't work and use at the same time, one reason I'm not currently working.
 
awesome post man. after 3 years of opiate/legal buds use mainly heroin i stutter alot more i like spaces in my thinking i say umm 1000 times. not only that i actually live a healthy lifestyle i eat clean and train. im still retarded though it fuckin sucks. its tough as hell to learn things. i get depressed and lazy often too. been clean off dope for 9 months now too, well i slipped here and there but didnt start up again.
 
well i was a long time user/addict of opiates(oxy,heroin,methadone) but have been clean from thenm for 6-7 years..the biggest problems i have noticed from my opiate use are the following

1-anhedonia, persistent low lying anhedonia is present i my life..exercise and medication only help to a very small degree..

2-lack of 'get up and go'..lack of motivation is also a problem..low energy too

3-i seem to have memory problems, difficulty concentrating but the major problems i have noticed are the above 2 symptoms..tbh i have thought about going back on some opiate maintanence treatment just to feel normal again..

are you doing ANYTHING else at all? cause your post makes me depressed as shit dude. i have all those symptons and i struggle to see cure it whatever way i can. its just the learning and motivation that i really want back. i want to do everything someone my age is supposed to be doing.
 
good post..luckily i was 27 when i started heroin..hmm i still believe that alcohol causes A LOT more damage to the brain and it is still acceptable to drink and some young people find it even cool to be binge drinking..
 
well i was a long time user/addict of opiates(oxy,heroin,methadone) but have been clean from thenm for 6-7 years..the biggest problems i have noticed from my opiate use are the following

1-anhedonia, persistent low lying anhedonia is present i my life..exercise and medication only help to a very small degree..

2-lack of 'get up and go'..lack of motivation is also a problem..low energy too

3-i seem to have memory problems, difficulty concentrating but the major problems i have noticed are the above 2 symptoms..tbh i have thought about going back on some opiate maintanence treatment just to feel normal again..


I have this to the worst degree ever, im 20, i literally dont have the energy to do anything, like its so terrible, ill be fucking dope sick, and i dont have the energy to drive a few houses down and get shit. Any solutions you find i would be very interested.
 
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