RCs Novel stimulant 2-Hydroxy-4-Ethylphenmetrazine (2-HO-4-EPM)

[roi]

4-ethyl-2-hydroxy-3-methyl-2-phenylmorpholine

That would be the first 2-substituted phenmetrazine derivative on the RC market so far.

Does anyone have a little more information on this one?

 

[sekio]

As a hemiacetal this will open to N-ethyl-N-(2-hydroxyethyl)-cathinone.

 

[roi]

Recently renamed to "2-HO-Phenmetetrazine".

 

[THCified]

Interested in how this one will be compared to regular Phenmetrazine effects-wise (which is, at least that's what i gathered on info about it, a lovely Chem). Afaik 3F-Phenmetrazine doesn't have much/if any similarity to it's Parent Compound, right?

 

[roi]

Update: Now it's called Phenhometetrazine. Oh well.

 

[psynce of sound]

So if what Seiko said is correct this is possibly going to be a prodrug to a cathinone. Would this cause any issues under current UK laws?
Also any speculation if it is a prodrug then will it have a varied effect spectrum.

 

[roi]

Phenmetrazine analogues are legal in the UK.

 

[doppelgänger1]

As a hemiacetal this will open to N-ethyl-N-(2-hydroxyethyl)-cathinone.

Won't there still be the beta-OH instead of ketone?

 

[adder]

Won't there still be the beta-OH instead of ketone?

That's not how hydrolysis works. Hemiacetal hydrolyzes to a ketone/aldehyde and an alcohol. Here is a good example of the mechanism involved (the reaction at the bottom), the presented hemiacetal is also cyclic, the only difference is it hydrolyses to an aldehyde.

 

[sekio]

For those who want names, doodles, structures, etc.
Hydrolysis will probably be the major degradation route in "warm, wet" environments, like people, or bags that have got wet and left to dry, etc.
Dehydration will increase in environments where there's acid catalyst present and strong dessicants around to remove the water, or if the compound is heated excessively. So no smokin this one.

 

[adder]

This one is very similar to radafaxine. Apparently, it's going to be basically useless as a recreational drug. I doubt that any appreciable amounts of a secondary amine will be produced before it's excreted as it seems fairly hydrophilic.

 

[sekio]

I also thought N-alkyl phenmetrazines were inactive until dealkylated.

 

[roi]

Now "officially" called N-Ethylphenmetrazol.

 

[Ozle]

If this is indeed a metabolite of bupropion, then it's useless shit. I recall taking bupropion for my (admittedly excessive) smoking habit several years back, and apart from making me constantly on edge and anxious it did absolutely nothing for me.

 

[sekio]

It's closely related to, but not the same as, radafaxine (buproprion metabolite). This one is the 'metabolite' of N,N-diethyl-cathinone.

I don't know how pleasurable it'll be, for sure...