Has anyone else had the opportunity to taste (R) 7,α-dimethyl tryptamine?
It's not actually a totally novel compound. Back in the 1960s Upjohn identified that α ethyl tryptamine was a monoamine releaser/reuptake inhibitor and then went on to show that 7-methyl αET was an order of magnitude more potent (in animal models). The larger α side-chain meant it had vastly lower 5HT2a affinity so not trippy.. Hence αET was reputedly sold as MDMA (or MDA, I'm not certain just HOW it was presented).
What Upjohn failed to do was to try that 7-methyl in combination with their earlier work on methyl tryptamines. I think it most likely because they were aware that it likely had significant 5HT2a agonist activity. That there are two stereoisomers of the α substituted tryptamines is not discussed in any English language reference I am able to find. I'm uncertain if they hadn't found a way to resolve the isomers OR if the complexity of the synthesis made it less attractive. In some other nations resolution WAS evidently possible but who knows how facile it was?
For example, (S) αMT was briefly a novel antidepressant used in some Soviet Bloc nations under the brand-name Indopan. I believe 5-10mg once a day was the prescribable dose-range i.e. a dose that would not be hallucinogenic . So at least by the 1970s, Soviet chemists HAD resolved the isomers. I suppose when animal models are employed, the (S) WILL appear to be the active.
So, while the (R) isomer of 7,αMT is much less potent by mass, it's subjective effects are substantially different from the (S) or even a racemate.
I'm certainly in no position to state how safe (R) ) 7,α DMT is, but I can confirm that at 75mg, the subjective effects are very similar indeed to those of a similar dose of MDA. I was emphatically warned to consume the sample orally and veiled references to negative experiences resulting from people vaping the stuff.
I'm a little surprised that this compound isn't more common. But if I had to guess, it would be that the resolution step poses significant problems. It's entirely possible that to reach an appropriate EE, resources and yields make it unattractive. After all, either you are throwing away over half the product (the (S) and mechanical losses) OR you have to perform a racemization on the unwanted isomer.
I am in no way promoting this compound, merely noting that there exist a number of tryptamine derivatives that display classic entactogen effects
It's not actually a totally novel compound. Back in the 1960s Upjohn identified that α ethyl tryptamine was a monoamine releaser/reuptake inhibitor and then went on to show that 7-methyl αET was an order of magnitude more potent (in animal models). The larger α side-chain meant it had vastly lower 5HT2a affinity so not trippy.. Hence αET was reputedly sold as MDMA (or MDA, I'm not certain just HOW it was presented).
What Upjohn failed to do was to try that 7-methyl in combination with their earlier work on methyl tryptamines. I think it most likely because they were aware that it likely had significant 5HT2a agonist activity. That there are two stereoisomers of the α substituted tryptamines is not discussed in any English language reference I am able to find. I'm uncertain if they hadn't found a way to resolve the isomers OR if the complexity of the synthesis made it less attractive. In some other nations resolution WAS evidently possible but who knows how facile it was?
For example, (S) αMT was briefly a novel antidepressant used in some Soviet Bloc nations under the brand-name Indopan. I believe 5-10mg once a day was the prescribable dose-range i.e. a dose that would not be hallucinogenic . So at least by the 1970s, Soviet chemists HAD resolved the isomers. I suppose when animal models are employed, the (S) WILL appear to be the active.
So, while the (R) isomer of 7,αMT is much less potent by mass, it's subjective effects are substantially different from the (S) or even a racemate.
I'm certainly in no position to state how safe (R) ) 7,α DMT is, but I can confirm that at 75mg, the subjective effects are very similar indeed to those of a similar dose of MDA. I was emphatically warned to consume the sample orally and veiled references to negative experiences resulting from people vaping the stuff.
I'm a little surprised that this compound isn't more common. But if I had to guess, it would be that the resolution step poses significant problems. It's entirely possible that to reach an appropriate EE, resources and yields make it unattractive. After all, either you are throwing away over half the product (the (S) and mechanical losses) OR you have to perform a racemization on the unwanted isomer.
I am in no way promoting this compound, merely noting that there exist a number of tryptamine derivatives that display classic entactogen effects
