Nootropics to battle withdrawal

[JonnyDeath]

Nootropics are said to be the "smart" drugs.
Drugs that help you focus, remember etc.

They also are incredibly effective for battling withdrawal because they are neuroprotectants.
As many of you know, addiction starts in the brain even in regard to physical dependency.

I will not publicly declare myself an addict or drug dependent because I am not...I also know the legal system intimately and why such a declaration is a shot in the foot too many people today are manipulated into
.
I can however help people battling withdrawal particularly opiate or synthetic opiate withdrawal as there is new information proving synthetic opiate withdrawal can be worse than organic.
Also be aware that to be a synthetic, it's not necessarily man made as in completely synthesized from compounds but, a new type of opiate is made from an organic opiate and this is why it is labeled synthetic or partially synthetic.

Noopept is probably your go to guy to wipe out a lot of withdrawal symptoms specifically those which are psychosomatic, psychoneurotic etc.

As we are all wired differently, one might have a nightmare coming off codeine while another is fine while the very same two are opposite on a synthetic like Tramadol or even Methadone withdrawal.
I've been on a variety of pain killers as prescribed and a handful of times just for the fun of it.
I am reading a lot of arrogance from people from one drug to the next.
I booted hydrocodone without any real withdrawal...more easily than cannabis in fact so we are all incredibly different.

I believe a lot of withdrawal differences have to do with emotional dependency as opposed to physical.
Emotional dependence also has a huge effect on peace of mind so the ability to think rationally is also a tremendous issue.
Anything can act as an antidepressant depending on the individual so quitting anything can result in serotonin gone haywire.

Again I can not stress it enough.
If you're going off of anything but most specifically a synth or natural opiate, get yourself some Noopept and Aniracetam.
I don't sell the shit, am not involved in the industry and have nothing to gain.
I can just assure you it works incredibly well and you are not trading one dependence for another.

Nootropics are a really bizarre, new class of drugs and I imagine if someone produces one that is recreational, it will take the world by storm because there will never be a dependency issue.

 

[RoboRobot]

This is an interesting topic. Both nootropics and synthetic opiate withdrawal are in my life, so Im quite interested.

Do you have any studies or proof of this? (not that Im discrediting you, just wondering.)

 

[yfmpro350]

you deff got my attention but what is a nootropics

 

[JonnyDeath]

While I am not and never have been drug addicted or drug dependent, I have had withdrawal when going off long term use of prescribed medication.

Nootropics are a new class of drugs with clinical studies all across the board which is why so many remain unregulated and unclassified. The drug has not been used to corner a specific area of medicine but when that happens, we will begin to see more of these drugs land on the list of controlled substances.
However, there are already Nootropic drugs that are controlled substances that must be prescribed by doctors in the USA.

Nootropics are drugs that cross the blood brain barrier and effect neurological processes of the brain and, the brain's interaction with the organs of the body.
This means biochemical and neurological involvement with 100% of the body but most specifically, it all starts in the brain once metabolized.

New is in regards to just a couple years which when you're young, seems like what it is not. A long time.
A 10 year mark is pretty standard and some very dangerous drugs remain on the market for decades before finally being banned.

My comment on Nootropics for withdrawal are first hand experience.
Wipes it out in about 5 minutes.
Just like opiates, these drugs can pass the blood brain barrier.
These drugs effect neuroreceptor uptake of key chemicals produced by our body that interact with various organs in the body.
Noopept, a neuroprotectant, is by my theory protecting the brain from the physical withdrawal's burden on the brain.

This is what destroys a chance at full recovery for most people.
If you were feeling like you were fighting off a vicious flu or other viral infection but had peace of mind and peace of emotion, successfully defeating the addiction would not be such a scary and seemingly impossible goal.
Weening and addiction/dependency supplementation work but to what extent?

Weening seems to be the best course of action for pharmaceuticals.
Supplementation has shown it never works considering that successful addicts never leave the rehab program.
They go to work in the rehab field and if they did not, would definitely return to drug dependency or abuse.

A drug you take that wipes out the mental and emotional neurosis, psychosis etc. and has no high or addictive potential?
I believe that what is occurring is the drug is protecting the brain from the organs.(research the "gut brain" to get a better grasp of an organ's power over the brain)
Rather than suppress the brain and various organ conflict through what I will simply refer to as a numbing agent, the nootropic must be governing the biochemical/neurological interaction between brain and major organs.

All I can say for certain is try it for yourself.
Try more than one.
I've only taken Noopept and Aniracetam primarily in combination and in mega mega dosage.
I wasn't aware of proper Noopept dosing and took 1 full gram.
However.
Even under proper dosing, I just didn't experience much until I took much larger dosages.

This link runs the gauntlet of lab experiments with Noopept.
You can also perform a "noopept toxicity" search yourself.
It's been shown to be safe and when examples of organ stress were noted, they were found to be completely reversible.
Also be aware that they give these lab rats, rabbits, dogs etc. doses that are insanely high.
Not only based on body weight but metabolic rate so it's beyond equivalent of us taking 10 grams of a drug in question.
It's more like 100 grams possible 1000 because these animals have anywhere from 5x to 25x the metabolic rate of a human being.

http://www.ncbi.nlm.nih.gov/pubmed/?term=noopept

 

[Coolwhip]

Not to nitpick, but while you may have not been addicted, if you went through withdrawals then, by the very definition of the word, you were dependent.

 

[JonnyDeath]

Not to nitpick, but while you may have not been addicted, if you went through withdrawals then, by the very definition of the word, you were dependent.

Dependent falls under many terminological definitions with drugs though.
Withdrawal from a substance can also be defined as a biological opposition to what was established, normal body chemistry because your body has incorporated it into other biological processes related to specific organs, tissues and their normal functions.

Dependent is abused as a legal safety synonym for addicted to keep drug dealing Dr Feilguhds out of jail lol

I'm dependent on food because if I do not eat it I will die.
I'm not dependent on a drug because if I do not take it, my body will adjust while symptoms of withdrawal run their course.
Do you follow?

You are saying it accurately in regard to being dependent being synonymous with addicted however, withdrawal is not defined as only occurring if you are dependent/addicted.
Do you follow?

Withdrawal is not incriminating addiction or dependency.
It is incriminating of a change of behavior and an adjustment period.

If you say you are drug dependent in legal regard, nobody can twist your arm just yet but....
It's to say you are psychologically stable but your body is dependent and you do not need inpatient treatment, jail etc. to resolve this admitted problem with legal merit.
If you say you are addicted, you now wear the scarlet letter lol
This is self incrimination and they can twist your arm.

If you say you experienced some withdrawal from caffeine?
Withdrawal from cheeseburgers?
Withdrawal from orgasms?
There is no legal merit when you use the word withdrawal if you stop anyone with something to gain from parlaying it into an admission of dependency or addiction.

I've experienced withdrawal from many things be it happiness, a person's company, a band, a foreign substance taken internally and incorporated into my biochemistry.
I have not however been dependent or addicted to any of those things.

Are you dependent or addicted to feeling good from riding roller coasters or swimming?
Of course not but, you will experience forms of withdrawal mentally and physically if you do not feel good for a great length of time.
The English language is fascinating but few will ever know just how advanced the technology of language is until they learn some Legalese or the form of English used in fields of engineering.
I've done a bit in both.

 

[RacemicNature]

OP, Have you ever experienced real acute opiate withdrawal? No offense, but i think noopept, or any nootropic, will fall way short of being the panacea that you are claiming. i've tried it and at most it can soften subtle aspects of the mental withdrawal, but barely noticable really. Perhaps it can protect your brain against damage from excitotoxicity and the like, but the tangible experience of pure misery and akathisia is hardly affected. Yes, everyone is different, but there are far better "go-to's" to buffer the experience of withdrawal. I would be interested in the nootropics effect on the duration of withdrawal however...

 

[JonnyDeath]

OP, Have you ever experienced real acute opiate withdrawal? No offense, but i think noopept, or any nootropic, will fall way short of being the panacea that you are claiming. i've tried it and at most it can soften subtle aspects of the mental withdrawal, but barely noticable really. Perhaps it can protect your brain against damage from excitotoxicity and the like, but the tangible experience of pure misery and akathisia is hardly affected. Yes, everyone is different, but there are far better "go-to's" to buffer the experience of withdrawal. I would be interested in the nootropics effect on the duration of withdrawal however...

I have but consider the diversity of drugs containing opiates, semi-synthetic opiates and synthetic opiates today and the way they're both used and abused.
Pills.
Snorting.
Smoking.
Intravenous.

Have you ever experienced acute opiate withdrawal?
There's a massive lack of information in your question.
Personally cannabis has been sufficient to eliminate withdrawal completely but we're all different and I was an extremely heavy cannabis user for more years than I can even calculate before experiencing long term opiate use.
I've never snorted, smoked or injected so I am surely at the lower level of intensity but it's still a rather miserable experience.
On the other hand the opiate I've withdrawn from, which will remain unnamed, is ranked worse than heroin by many others who have suffered through a wide variety of opiate withdrawal. When your serotonin receptors start functioning again you're being slammed by every emotional low that was suppressed during the length of use all at once during withdrawal.
For me it was far worse mentally and emotionally than physically because unlike 99.999% of drug users I'm extremely active physically working out anywhere from 3 to 5 times a week.

You'd be surprised what doing 500 jumping jacks, 200 curls, 200 rows etc. will do for physical withdrawal aside from simply pushing the drugs out of your system on a regular basis.
A very large dose, as in over a gram, of noopept and aniracetam was enough to subside the extreme mania the withdrawal was putting me through.
That 7 or 8 days of withdrawal was easily as bad as when I suffered a severed sciatic nerve that for about 6 months made every single movement in any way, shape or form by any body part equivalent to being shot PBR by a rifle each and every single time and I've had more severe injuries that hurt a lot less.
My first surgeries being at the age of 10 which result in my first exposure to opiates which was intravenous.

So yes, I have definitely experienced acute opiate withdrawal but I'm not your typical couch potato or alley dwelling drug addict either. Even the typical long term cannabis user today will do some rather humiliating things for a bag of weed I wouldn't dream of doing even when going through the living nightmare of withdrawal I've experienced twice on synthetic opiates.

 

[Fornax55]

This is a bump but I U'dTFSE and came up with this so... are either of the two people who posted in this thread still kickin' around? I've got some Qs to ask you two, or anyone who could answer... although, Jonny, your ability to hide specifics and keep parts of your answers hidden makes me somewhat doubt your legitimacy...

anyway, does anyone have any experience with this? Any idea why OP would choose Noopept and Aniracetam over the dozens of other nootropics? I have both of these , and a host of other nootropics but I don't want to experiment with them until after I've stopped taking illicit substances so as to not clog up my brain with too many different substances and possible interactions.

 

[《Plasticity》]

I'm physically dependent on opioids and have been using aniracetam, noopept, and alpha GPC along with a few other things like Mucuna Pruriens for the past few months... experimenting and playing with each individualy and in combination. I see no improvement in withdrawal symptoms when on any of these drugs, not even withdrawal induced depression and anxiety unfortunately.

Oddly enough they worsen rebound symptoms I get from drinking alcohol, though I only ever started getting rebound from drinking in the first place due to being dependent on etizolam a while back. From what I remember noopept and other nootropics affect glutamate. Not sure if that has to do with my increase in GABAergic rebound effects.

I have been having great success lessening opioid withdrawal with calcium channel blockers though, verapamil in particular. Not surprisingly I discovered that it has been demonstrated to be an effective withdrawal aid (1, 2, 3, 4). It is also very effective at preventing the development of tolerance and dependency. Anyways, this thread isn't about calcium channel blockers so I'll shut up .

 

[DarkStarCrashes]

I find that the use of phenibut greatly helps withdrawal symptoms, especially if one has not been using phenibut daily prior to the withdrawal. It provides a sense of well being and euphoria that counter some of the depression of the withdrawal, as well as providing a significant amount of energy when used at appropriate doses to counter the lethargy associated with W/D. As phenibut is structurally similar to both gabapentin and pregabalin, both of which also help during withdrawal, it also helps eliminate RLS. When used in addition to gabapentin or pregabalin its effects are potentiated although dose should be lowered accordingly. If you add tramadol into the mix for its delta opioid receptor activity and kratom for its mu receptor activity you may be able to supply yourself with an affordable and realistic backup supply to have on hand at all times when you begin the withdrawal process.

Of course, the best and most efficient way to avoid withdrawal is to cease the use of opiate and opioid drugs completely - perhaps by way of a bupe or methadone maintenance program. Best of luck to you.

 

[chrisincville]

"I have been having great success lessening opioid withdrawal with calcium channel blockers though, verapamil in particular. Not surprisingly I discovered that it has been demonstrated to be an effective withdrawal aid"

Similar to the way gabapentin works (while not a calcium channel blocker, it does modify said channel to produce some of the same effects). Yes? No?

 

[《Plasticity》]

Couldn't tell you. Gabapentin's MOA is still poorly understood and AFAIK it isn't known why it helps with opioid withdrawal, although it definitely does help. Aside from it's action on voltage gated calcium channels it is also theorized to modulate GABA and glutamate.

Both seem to help in the same way though. That is by actually reducing symtoms as opposed to just masking them like a benzo would. Verapamil doesn't even have any effects or symptoms besides slightly lowered blood pressure and withdrawal relief, IME at least.