So I was very intrigued after coming across information regarding a substance produced in the brain called nociception. It apparently is produced much like natural endorphins in the brain, except it basically has the opposite function. It makes animals feel pain/sensitivity, and in opiate addicted animals, it is found in higher levels, and is probably responsible for tolerance building. (Non-junkie) Animals shot up with this basically exhibit classic withdrawal symptoms. It is a necessary chemical in brains of animals and humans, as without it we wouldn't feel pain
Just to be clear this is not like narcan/naloxone etc where it blocks opiates and rips extras out of your receptors. It's not an antagonist, it's actually sort of an inverse-agonist.
I've researched this as much as possible but still not sure if I totally get it. Is everything I have above true? That's basically what the interwebz various sources said. Also curious if you could somehow repress it, cold you stop tolerance from building? Also could you stop from having withdrawals? Obviously opiate addiction causes your brain to make less natural opiates, and that's where I always assumed withdrawal came from, your receptors being empty because they're used to being overloaded. Is it 50/50 receptors empty of opiates and others filled with the nociception? Or how does that work?
TL;DR what role does nociception play in addiction/how is it altered during addiction, how does it effect tolerance? Can it be controlled? Etc. Understand basically how it works in normal animals/people, but interested in its role in an opiate addicted body
I'm sure I've made a fool of myself as I know nothing about how this works. Try to be nice, and keep it simple as possible
Just to be clear this is not like narcan/naloxone etc where it blocks opiates and rips extras out of your receptors. It's not an antagonist, it's actually sort of an inverse-agonist.
I've researched this as much as possible but still not sure if I totally get it. Is everything I have above true? That's basically what the interwebz various sources said. Also curious if you could somehow repress it, cold you stop tolerance from building? Also could you stop from having withdrawals? Obviously opiate addiction causes your brain to make less natural opiates, and that's where I always assumed withdrawal came from, your receptors being empty because they're used to being overloaded. Is it 50/50 receptors empty of opiates and others filled with the nociception? Or how does that work?
TL;DR what role does nociception play in addiction/how is it altered during addiction, how does it effect tolerance? Can it be controlled? Etc. Understand basically how it works in normal animals/people, but interested in its role in an opiate addicted body
I'm sure I've made a fool of myself as I know nothing about how this works. Try to be nice, and keep it simple as possible
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