Bupe No effect from 16mg suboxone snorted

[bluecollartweeker]

I decided to abuse my script today because i was getting extreme heroin cravings and wanted to snuff thosd out, but after railing all the powderd generic pills its been ebough time that i should be feeling high but im not. Is it because the naloxone in it is that strong it can kill the high from a 16mg dose?

 

[DeathIndustrial88]

It's because buprenorphine has a ceiling effect.

After enough is built up in your system, taking more doesn't do anything or cause any increase in effects.

Honestly after about 4-8mg, subs aren't going to really produce any more or better effects.
By 16mg, all of your opioid receptors are completely covered & no more bupe can attach to anything.
It builds up with daily use too, so if your taking it every day, then you have a bunch built up in your system.

Not only does it have a ceiling effect but it's also only a partial agonist, so it's not going to activate your receptors all the way.
Think of your receptors as locks & the drug molecules are the keys. Full agonists like heroin fit perfectly into the lock & open it up. Partial agonists fit but are the wrong shape, so they don't fit all the way & can only open the lock ever so slightly.

I can explain the whole way buprenorphine works but that's basically the gist of it. Taking more subs doesn't do anything.

 

[bluecollartweeker]

Im on 16mg daily for maintnence after a morphine and heroin addiction, where my tolerence to morphine reached 600mg at its peak. So does that mean i can take 8mg and stay in successful maintnence while pocketing the rest of the dose?

 

[DeathIndustrial88]

Im on 16mg daily for maintnence after a morphine and heroin addiction, where my tolerence to morphine reached 600mg at its peak. So does that mean i can take 8mg and stay in successful maintnence while pocketing the rest of the dose?

Yeah probably.

Buprenorphine is incredibly potent.
In Europe, buprenorphine gets used for pain in doses as low as 0.02mcg.

So as long as you aren't still withdrawing from morphine & heroin, you could easily drop your dose & probably be fine.
I do think the higher doses can some times help with cravings psychologically, but in reality, yeah anything over 8mg is pretty much overkill (unless you're coming off of a full agonist).

Most doctors also don't want people to discover that at around 2mg & under, you actually start to get a buzz from your bupe (although not a very good one). This is because the lower doses allow for your blood levels to drop sooner & to have receptors open to receive your next dose, which causes a mild buzz. So I think they keep people on ridiculously high doses so that their blood levels are constantly maxed out & they never feel their bupe. I think this is super counter-productive if the goal of maintenance is to help with cravings, but I digress. I could complain about how our healthcare is run all day. lol

 

[bluecollartweeker]

Fascinating, thanks for informing me

 

[DeathIndustrial88]

Fascinating, thanks for informing me

No problem!

And yeah the naloxone in subs is basically pointless.

Back in the day it use to be Subutex (straight buprenorphine). But the makers of Suboxone came up with the buprenorphine/naloxone combo & patented it as "Suboxone", claimed their product was "less abuse-able" due to the naloxone. Except bupenorphine is so strong at your opioid receptors that not even naloxone can displace it.

Many people think the naloxone is what causes withdrawals when they take bupe on a full agonist too, but that's not the case. It's actually the bupe that causes withdrawals because it's so strong that it rips other opioids off your receptor & replaces it with itself, leading to less receptor activation.

So yeah, the naloxone is useless.

 

[bluecollartweeker]

Wow that explains alot! Thanks.

Im going to over share here, but its cuz im spun on ritalin.

The receptor fighting explains why i got so sick after injecting a micture of 10mg oxymorphone and whatever half a pill of hydrocodone was while on 8mg of subs, it was a bad idea but i was emotional because my ex girlfriend made sure to remind me she was lying everytime she said she loved me, i was hoping id get high enough to atleast forget the pain but it wasnt a suicide attempt. (I only ever made a suicide attempt once with an OD if aripiprizole and i survived and the aftermath completely ruined my life but now 9 months later ive neve been happier to be alive!) If it wasnt for the subs maybe it wouldve been an OD. Its been 5 weeks since that day and i havnt touched a needle,

 

[DeathIndustrial88]

Wow that explains alot! Thanks.

Im going to over share here, but its cuz im spun on ritalin.

The receptor fighting explains why i got so sick after injecting a micture of 10mg oxymorphone and whatever half a pill of hydrocodone was while on 8mg of subs, it was a bad idea but i was emotional because my ex girlfriend made sure to remind me she was lying everytime she said she loved me, i was hoping id get high enough to atleast forget the pain but it wasnt a suicide attempt. (I only ever made a suicide attempt once with an OD if aripiprizole and i survived and the aftermath completely ruined my life but now 9 months later ive neve been happier to be alive!) If it wasnt for the subs maybe it wouldve been an OD. Its been 5 weeks since that day and i havnt touched a needle,

Hmm,
Well technically you can use full agonists on top of bupe.
It's only when you take bupe after a full agonist is in effect that it should cause problems.
For example if you're taking hydrocodone every day for a week & then you take 8mg of subs before it's worn off, then it will throw you into what is known as "precipitated withdrawal". But if you take hydrocodone on top of buprenorphine, it'll either do nothing (because bupe is blocking it) or just cause added effects (depending on how many receptors you have open for the hydrocodone to attach to).

I've used full agonists on top of my bupe many times in the past & have been fine.

So I'm not quite sure why you got sick.

I hope I don't sound preachy here, but shooting pills is pretty bad for you. If you're going to do this, it's best to have micron filters. Because some of the binders & fillers in the pills can get lodged in your circulatory system if they're not water soluble. It's possible you either just got sick from taking too many opioids or possibly from the injection itself.

I personally am pro-legalizing heroin & opioids, but I'm against using needles, as they can cause problems that you wouldn't have otherwise had to worry about if you had done the drug any other route. It can lead to infections, heart problems, loss of limbs, circulatory damage, etc..

So it might not mean much coming from a total stranger on the internet, but I'm proud of you for putting the needle down & leaving it down! Nothing wrong with getting high, as long as you're doing it in the safest possible way!

 

[neu_nobody]

Im on 16mg daily for maintnence after a morphine and heroin addiction, where my tolerence to morphine reached 600mg at its peak. So does that mean i can take 8mg and stay in successful maintnence while pocketing the rest of the dose?

You can take even less. They prescribe such insane dosages to block the receptors so you won't take heroin or morphine.
And like another person said, bupe indeed feels better in lower dosages. When I was using bupe, I felt the best on 2-4mg max. Anything more - and you are getting all the side effects, without any positive effects.
In a place where I live, drug addicts on substitution program use 1/2-1/3 of their prescribed dose, and save the rest.