NMDA antagonists... dumb question...

[blase deviant]

...okay NMDA antagonists prevent tolerance to pretty much everything.

So, do NMDA antagonists prevent tolerance forming to each other?

E.x. if you took 30mg DXM or so and then did Ketamine, would it remove your tolerance/would you be able to do it the next day with no tolerance rising?

Or does it work the opposite way, and would taking different NMDA antagonists consecutively or together increase your tolerance?

Yeah, this is pretty stupid, but I was curious.

 

[BilZ0r]

Taking DXM on top of ketamine would just be like taking more ketamine as far as the NMDA receptor is concerned.

 

[5-HT2]

^^^well, perhaps not as far as the receptor is concerned, but probably as far as tolerance is concerned.

 

[BilZ0r]

How would that work? Tolerance develops to some of the behavioural effects and the interoceptive cues of NMDA receptor antagonists[1, 2]. How would taking more of an agonist for an ion channel, reduce tolerance to another agonist for that ion channel.

Or is it a site thing? Ket and DXM different sites on the channel?