Health New molecular structure for psychedelic drugs : ZC-B and LPH-5

[Dr.Methyl]

Here are the molecules :
- ZC-B https://en.wikipedia.org/wiki/ZC-B
- LPH-5 https://en.wikipedia.org/wiki/LPH-5_(drug)

It seems now some companies are aware of the use of hallucinogens to threat some disorders such as alcoholism/addiction and depression. But the problem is the actual tests for exemple those made by MAPS are made using well-known molecules such as psilocybine or LSD but theses molecules are in public domain a long time ago, therefore they couldn't be patented. So they developed new 5-HT2A agonist for the future market. I think they will develop also their own therapies to sell the molecule. This is a new era in the prechedelic use as treatment.

They're not so hard to synthetise and I would be happy to test ZC-B or the 2C-B analogue of the LPH-5 !

 

[emkee_reinvented]

Sounds nice, might as well have included modifications on 2C-T2.
My absolute favourite or 2C-E, Mescaline , the grail, unknown to me.

Ditched Kilos home grown San Pedro, for my exes pregnancy.
Kids and Cactus, according pregnant woman [mine] is murderer.
And males become softies as they get kid s, so the Cactus-ses lost.
Absurdisme won, San Pedro being about a spineless Cactus.

Woman pregnant [mine] lost the logic part of her mind.
So poison s were alright, Catusses killers, just for guy s.
That didn t reproduce yet.

Maybe she never had it in the first place mine ?
A logic mind.

 

[perpetualdawn]

Really interesting, thanks for sharing @Dr.Methyl Tantalizing to think about whole new branches on the psychedelic family tree opening up, even if they do get patented and locked up. I'd be very curious to try these if they turned out to be safe. The selectivity of LPH-5 for 5ht2a over 5ht2b sounds like a good contender for semi chronic dosing like microdosing with less risk for heart valve issues.

Pity about those cacti @emkee_reinvented - my wife raised some similar concerns when she was pregnant but agreed that the spines would be a big deterrent, never mind the horrible taste. My boy toddler did end up plucking a 5 year old peyote cactus out of its soil, and then kind of crushed it. It was sad for a moment but it was easy to reflect that it would be more fun watching him grow up anyways.

 

[emkee_reinvented]

My first born was allowed to play with my CD s.
"Yeah imagine if she would have missed that motorist development',
what then ? my lovely lil girl would get retarded. Yeah for sure.
If you miss the logic part of your brain.

The CD s ended in the dumpster bruised and battered,
bye bye 1000,-s of investment. Crazy.

 

[Esperighanto]

Catusses killers, just for guy s

Sounds like you knocked up a wacky woman bro, but cactus powder can be easily mislabeled and hidden before extraction, ngl.

It was sad for a moment but it was easy to reflect that it would be more fun watching him grow up anyways.

Next time dehydrate it and store it away for later!

@Dr.Methyl LPH-5, TCB-2, ZC-B, etc all represent novel scaffolds that could also potentially be made as FLY/Butterfly/Dragonfly compounds, and their hemi-versions as well. 2,4,6 and 3,4,5 substitutions of phenethylamines can also be applied to the same strategy as the three newer scaffolds, which really, much like phenylmorpholines (like phenmetrazine) they work on, seemingly, aromaticity and the nearby presence of a nitrogen. Arylcyclohexylamines are arguably just this and cyclohexanol with an alkyl group on other side, and tryptamines are highly reminiscent of the Indole analogs of phenethylamines, think about benzofurans also being off by a single oxygen. Uncommon nitrogenous substitutions on phenethylamines (FLY-type variants included) are also active, N-[OH/BMD] all show activity, as do Beta-[MeO/HO/EtO/Me/Keto], so per unique 4-substitution you've got five possible nitrogenous substitutions (including unsubstituted, NBOH and NBOMe as well), times 6 unique beta substitutions, three alpha substitutions if including the DOx's and 4Cs, and the subtitution at the 4th position could be 2C-[B/C/I/iPR/Pr/YN/AL/CP/V/E/D/T-X/BI-X], 5*6*4=120 unique phenethylamines, not including any of the FLY business, Tweetios, or things like the recently patented 2C-E-5iPR. Among other substituion patterns, there are also odd configurations, your metaescalines and TOMSOs and the sort, from the depths of PiHKAL.

The majority of the newer Trachsel-era ones (2C-YN/V/AL/CP], as well as the 2C-T's and 2C-BI's are close in production processes to 2C-B or 2C-I, but alkyl substitutions have their own pain-in-the-ass routes. Nitrogenous and beta substitutions are technically very simple but it is another step, I was always curious why Beta-methyl, beta-keto, or beta-meo 2C's weren't more popular.

 

[xdrc]

Can you link the 2C-E-5iPr patent please? I assume the 5-isopropoxy compound?

 

[emkee_reinvented]

Dehydrating for the unknown is easy done in a self defrosting fridge.

Which is basically freeze drying, before thinking bout chemical dehydration,
Would i ve had one att i done it but drying turned the San Pedro to funghi mush.

 

[Esperighanto]

Can you link the 2C-E-5iPr patent please? I assume the 5-isopropoxy compound?

Here's a link with the DOI so you can Sci-Hub it.

 

[perpetualdawn]

Next time dehydrate it and store it away for later!

So small it wasn't even worth it. Peyote grows so slowly, even after ~5 years I think it was <1cm across.

 

[Esperighanto]

So small it wasn't even worth it. Peyote grows so slowly, even after ~5 years I think it was <1cm across.

Jesus man even the tiniest buttons should be an inch or two within 3 years of indoor cultivation, were you starving it of light or something? <1cm is insanely small in amount, it took maybe 2-3 fistfuls of peyote to even notice it as far as effects go. I'm suspecting this was hardgrown outdoors to be so small after so long?

 

[emkee_reinvented]

Jesus man even the tiniest buttons should be an inch or two within 3 years of indoor cultivation, were you starving it of light or something? <1cm is insanely small in amount, it took maybe 2-3 fistfuls of peyote to even notice it as far as effects go. I'm suspecting this was hardgrown outdoors to be so small after so long?

My two headed Peyotl, never grew notice able.
It did flower, get sun, special soil, special succulent fertiliser.
Was in good healt but in 5 years was still as big as when bought.

Slow runner, Peyote s !

 

[Esperighanto]

My two headed Peyotl, never grew notice able.
It did flower, get sun, special soil, special succulent fertiliser.
Was in good healt but in 5 years was still as big as when bought.

Slow runner, Peyote s !

Wow, if it was flowering it must've been at least happier than not! I have a tough time getting Lophophora to flower compared to Ariocarpus which flower like motherfuckers. Have you ever dabbled into the world of the "false peyotes"?

 

[emkee_reinvented]

No only experience was with MethylAllylEscaline,
and took 20/ 30 mg both to low to notice.

Should have taken all in one go, but me bit to careful.

San Pedro, few KG, homegrown, in the wastebin when i got kids
My Bitch was, well a bitch and now also a ex.
Who knicked my kids, so actually a

 

[Esperighanto]

No only experience was with MethylAllylEscaline,
and took 20/ 30 mg both to low to notice.

Should have taken all in one go, but me bit to careful.

San Pedro, few KG, homegrown, in the wastebin when i got kids
My Bitch was, well a bitch and now also a ex.
Who knicked my kids, so actually a

I usually purchase SP in ten pound intervals, the ugly cuts that couldn't sell well so I get them mad cheap, powderize and extract from there. It's the way to do it imo. Can be a quick, lean, mean operation with CIELO tek or just an acetate extraction.

I'm interested in synthesizing some of the tetrahydroisoquinolines (THIQs) that give peyote a unique experience, to combine with non-mescaline phenethylamines to see what peyote would be like if it hypothetically contained a 2C-X or DOX, by being able to mix a 2C-X or DOX alongside some THIQs, you know? Might be neat.

 

[emkee_reinvented]

I usually purchase SP in ten pound intervals, the ugly cuts that couldn't sell well so I get them mad cheap, powderize and extract from there. It's the way to do it imo. Can be a quick, lean, mean operation with CIELO tek or just an acetate extraction.

I'm interested in synthesizing some of the tetrahydroisoquinolines (THIQs) that give peyote a unique experience, to combine with non-mescaline phenethylamines to see what peyote would be like if it hypothetically contained a 2C-X or DOX, by being able to mix a 2C-X or DOX alongside some THIQs, you know? Might be neat.

2C-T2 was my favorite, way above 2C-B/ 2-CE.
But i react poor too Phens and Trypts, don t know why.
My body doesn t like em. Except the [mainly 1-st] i mentioned.

That s why Lysergic s always disappear [in me].
While 4 off 5 DOC blot s lay years, waiting anticipating/ dissipating.

Who knows.

 

[Dr.Methyl]

LPH-5, TCB-2, ZC-B, etc all represent novel scaffolds that could also potentially be made as FLY/Butterfly/Dragonfly compounds, and their hemi-versions as well.

Don't forget the firefly ring that sounds very potent. Here in the picture is my tentative to make 2C-B-Firefly via double bartoli indole synthesis when I was working for D. Trachsel.

2,4,6 and 3,4,5 substitutions of phenethylamines can also be applied to the same strategy as the three newer scaffolds, which really, much like phenylmorpholines (like phenmetrazine) they work on, seemingly, aromaticity and the nearby presence of a nitrogen

I bet everything the phenylmorpholine and phenmetrazine are active like the 2c-x and its alpha-methylated DOX respectively. LPH-5 is in fact just like the phenylmorpholine but with a carbon instead of the oxygen. Here is a chloroacetylation methods of arenes with FeCl3.

Here's a link with the DOI so you can Sci-Hub it. (note: Request about 2C-E-5IPrO tweetio patent)

This document is very interessant indeed, there are comparison for a lot of exotic structures such as DOiBu, 2C-T-33 and BW723C86 with a strange (2-thienyl)methoxy group at the position 5 of the tryptamine... By the way I don't see any patent for the 5-isopropoxy 2C-E tweetio.

 

[perpetualdawn]

Jesus man even the tiniest buttons should be an inch or two within 3 years of indoor cultivation, were you starving it of light or something? <1cm is insanely small in amount, it took maybe 2-3 fistfuls of peyote to even notice it as far as effects go. I'm suspecting this was hardgrown outdoors to be so small after so long?

Yeah evidently I wasn't growing it very well. It could have been the conditions - I'm in a pretty chilly climate with dark winters. Maybe it got stressed somehow and it didn't get into a growing mood. I was never really sure why it wasn't doing much, and then when my son plucked it I kind of gave up. Maybe my soil was wrong. I always had them in as sunny a place as I could find. Dunno. I'd like to try again. I always wanted to do grafts on pereskiopsis. I had some of that for a while and endured its really nasty fine spines.

When I ate peyote (from the wild, years ago, I have some guilt about that now, and I wouldn't repeat because I really feel like non-indigenous people should be only eating cultivated peyote due to how threatened the plant is now) I think I only ate two or maybe three buttons and was quite flying. But they were real old peyotes, quite large diameter. Such beautiful plants.

 

[Esperighanto]

Don't forget the firefly ring that sounds very potent. Here in the picture is my tentative to make 2C-B-Firefly via double bartoli indole synthesis when I was working for D. Trachsel.

Fascinating, what's the logic on the SAR with a structure like this? I imagine that the idea would be the creation of a dimer that gets lysed via metabolism into something expected to be active, but do we have an understanding on how adjacent halogens like the two bromines in there would metabolize? Triisopropylsilyl groups are also something I've never seen on a medication expected to be consumed, do you think that would be safe? Genuinely curious here.

Must've been fascinating working in Trachsel's lab as well!!! Any experiences or learnings from there that you wish made it into his book Phenethylamines or his other papers?

I think I only ate two or maybe three buttons and was quite flying. But they were real old peyotes, quite large diameter. Such beautiful plants.

The size/age were likely highly relevant here. Research surrounding Lophs in general indicates that not only mescaline content, but also MAOI/THIQ content increases with age. Were the plants you harvested actively flowering? Without seeing the flower, you can't tell if there's even mescaline in a button (williamsii vs. fricii/diffusa genetics) so maybe what you caught here was an experience more fueled by MAOIs and THIQs than mescaline, if that makes sense.

 

[perpetualdawn]

Were the plants you harvested actively flowering? Without seeing the flower, you can't tell if there's even mescaline in a button (williamsii vs. fricii/diffusa genetics) so maybe what you caught here was an experience more fueled by MAOIs and THIQs than mescaline, if that makes sense.

At that time I had two different moments in the desert eating peyote. The first time, I don't think they were flowering. Then about 2 weeks later I went back in for another round. It had rained so the desert was in full bloom but tbh I forget if the peyote specifically was flowering (I think maybe not yet? I reckon I would remember that) but all kinds of other cacti were - barrel cacti etc - it was so colourful, beautiful and surreal. Anyways if the peyote was flowering I wouldn't remember enough detail to be able to ID the variety retrospectively. The region was in williamsii range and not fricii or difusa according a map I just looked at. Subjectively it had things common with later Trichocereus excursions, so I think there was mescaline in the plants. But who knows really.

Both times the buttons were so extremely bitter, it took a lot of mental fortitude and time to get them down, even just the 2-3 big buttons. By the time I got them down, I was already feeling woozy and couldn't have stomached any more. The second time a big meteor or something lit up the night sky at one point, and the next day lightning struck the ground 20-30ft in front of us on the way out. I don't know why it didn't hit us since we were sticking up higher than the ground. Celestial.

I'd love to go back there and just walk around and not eat any. It was such a magical place, I hope it's not been destroyed by ranching etc over-harvesting.

edit: sorry for taking this so far off topic here!

 

[Hexagon Sun]

Instantly falling in love. They seem really delicious... It´s time for the good of phens (well, kind of) to have a comeback