naltrexone rebound and use in the opioid naive

[Neuroprotection]

sorry if this has been discussed before, but I was wondering if there is any sort of rebound effect when stopping high dose long-term naltrexone. i’ve read one anecdote claiming that it created a natural but strong opioid high but I doubt this happens in most people.
I once read an article warning that stopping naltrexone after long-term use can cause reward hypersensitivity to alcohol and certain other drugs but unfortunately, I can’t find the article to post here.
This makes me wonder, as a person who has never tried opioids, what would happen if I took a high dose of naltrexone(50 to 100 mg) daily for a month or so and then stopped?
I’d love to know if anyone has tried this, especially if they had never used opioids
Thanks in advance.

 

[Neuroprotection]

Just for a bit more context, my intention isn’t to get an opioid high, but rather to enhance dopaminergic function, motivation and stress resilience. however, more than that, it’s just something I want to do out of curiosity

 

[Neuroprotection]

I’m really surprised this got no replies, does no one have any experience with this?

 

[darkFrozenLight]

I've tried the same thing as an experiment with both a one time dose of 50mg and then with a taking this for a length of time. This was over 10 years ago so I don't remember the specifics, but I experienced nothing after the one time dose or continual dosing. However, I'm one of those people who doesn't experience any negative effects from nalterxone, I know some people experience dysphoria while taking it so things might be different for them.

Also, I remember reading something (but maybe I'm misremembering) that naltrexone in the presence of no agonists acts like a very mild opiate agonist and this is why people sometimes get withdrawals from taking it for a length of time especially with low dose natrexone doses (1-5mg).

 

[Skorpio]

Don’t have the time for a full answer, but idk if naltrexone completely works its positive effects via reversing receptor down-regulation

It has some very beneficial effects on microglia via toll like receptor 4 antagonism, so if look toward that to answer your question .

 

[Neuroprotection]

Don’t have the time for a full answer, but idk if naltrexone completely works its positive effects via reversing receptor down-regulation

It has some very beneficial effects on microglia via toll like receptor 4 antagonism, so if look toward that to answer your question .

From reading many studies about aboutthe MU receptor, I got the impression that this receptor has many modulatory effects on neurons that have nothing to do with its traditional direct signal in pathway. if I remember correctly, it can form complexes with other receptors and might have some control over dopamine surface receptor expression.
What I found really fascinating is that MU receptors might be required for the experience of both positive and negative emotions, for example in response to music.

Anhedonia to music and mu-opioids: Evidence from the administration of naltrexone - Scientific Reports

Music’s universality and its ability to deeply affect emotions suggest an evolutionary origin. Previous investigators have found that naltrexone (NTX), a μ-opioid antagonist, may induce reversible anhedonia, attenuating both positive and negative emotions. The neurochemical basis of musical...

www.nature.com