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Mysterious stimulant in Slim Xtreme dietary supplement

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otto

Greenlighter
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First of all hello to this forum.

this is my very first post here and i would like to preemptively apologize in case that my question or anything related to my post might not be appropriate or perhaps better located in an other sub-forum.

I have consciously chosen the advanced discussion subforum, as I think that my question is a bit complicated and requires extended experience and deep insight / knowledge with regards to the pharmacology of designer stimulants and perhaps some experience with analytical chemistry, as I have also some GC/MS data at hand.

O.K., enough preface, let's start now.

As the thread title indicates, it's about a legally available dietary supplement that is pretty popular in the USA and in Europe (mainly in U.K.) and that has been introduced a few months ago by a dietary supplement company that used to produce and distribute products targeted to boybuilders, fitness-enthusiasts and athletes.

At the moment I won't mention the name of the product and of the company as I am not sure in how far this would be against the forum rules, but if I get green lights from admins or moderators, I can certainly mention the names in case that anyone is interested.


The said product is marketed for "fat loss", "appetite suppression" and "energy". Now, there are hundreds of such products, most of which are based on caffeine and some other herbal appetite suppressants. so far, so underwhelming.

However, this product unexpectedly gained a HUGE feedback from the user base (e.g. at bodybuilding boards/forums), with people reporting effects similar or even superior to methylphenidate or modafinil. Most strikingly, even one pill taken early in the morning (6 AM) causes whole-day appetite-suppression and mental energy, without the typical "crashes" that are known from caffeine/ephedrine based products. people report that they simply "forget to eat" and have to force themselves to down food in order to get a minimum of required nutrients. morover, during the first few nights, it is almost impossible to sleep, despite taking only one pill in the morning.

A comprehensive compilation of reported effects and symptoms:

- 12+ hours of appetite eradication
- extremely increased "mental energy"
- extremely increased drive to work
- insomina
- slight euphoria
- significant anxiogenic effects
- dry mouth
- dose-dependent teeth clinching / grinding
- hypervigilance
- tachycardia

While most people report that they got excellent focus and concentration, some reported amnesia-like effects, especially problems with working-memory.

Of course, it appears very probable that this dietary supplement is somehow adulterated or tainted with a designer stimulant, because according to the label it contains only 100 mg of caffeine, some amino acids (tryptophane, l-tyrosine), some herbal extracts ('cha de bugre' [=cordia salicifolia], acai berry extract, cocoa seed extract) and a minuscule amount of aniracetam. the total amount of the entire proprietary blend is 500 mg per serving. it is recommended to take only 1-2 servings in the morning (once daily).

So, many educated people tried to figure out and speculated what in all world would have such extreme effects that are entirely unknown from typical over-the-counter supplements. at various discussion boards, people have theorized that it might be modafinil or adrafinil or a derivative thereof, or perhaps a sibutramine derivative. People who have taken modafinil in the past have described the effects from this product as significantly stronger than modafinil, especially with regards to appetite suppression.

A chemist from USA got some caps sent by a concerned user and performed a GC/MS on it in his own lab. Unfortunately, although he is regarded as a world class chemist, he openly admitted that the spectrum is close to modafinil but does not match it entirely and that it most probably is a derivative he never heard of.

I have attached the mass spectrum on this product to this post and my question would be:

Does anybody have an educated guess what this stuff in question could be?
I have described the physiological effects as accurately and comprehensively as possible, and below there is the mass spectrum.

As I am one of the people who had been taking this product without knowing what it does contain (and still ebing clueless), I would really love to know whether anyone could help to figure out what is going on here.
Whic designer stimulants do you know would come close to the effects described here?


Any input would be very appreciated, regardless if pertaining to the GC/MS data or pertaining to pharmacological effects. Whoever does have a guess is highly welcomed to post it here.

Thank you very much in advance!!!
 

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Have you got the GC trace as well, because on its own that MS spectra is not very helpful.

it looks rather like diphenylmethylpyrrolidine.

in fact I will lay money on it. diagnostic ions are M/z 70 for substituted pyrroles C4H8N+ and 165 for diphenyl methane C13H9+

not sure about the world class chemist....
 
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Have you got the GC trace as well, because on its own that MS spectra is not very helpful.

it looks rather like diphenylmethylpyrrolidine.

in fact I will lay money on it.

not sure about the world class chemist....

Unfortunately, this is all I have. But I will get in contact with the chemist and ask him for the GC trace as well.

BTW, as you are moderating this section, I would like to know whether it is allowed or not to mention the name of the product and of the company.

I have already received PMs with people who are asking to get the information.

What should I do and what is allowed here?

Thanks!
 
Unfortunately, this is all I have. But I will get in contact with the chemist and ask him for the GC trace as well.

BTW, as you are moderating this section, I would like to know whether it is allowed or not to mention the name of the product and of the company.

I have already received PMs with people who are asking to get the information.

What should I do and what is allowed here?

Thanks!

post the name, I think naming the product is OK, don't post links to the company or to sources.
 
Have you got the GC trace as well, because on its own that MS spectra is not very helpful.

it looks rather like diphenylmethylpyrrolidine.

in fact I will lay money on it. diagnostic ions are M/z 70 for substituted pyrroles C4H8N+ and 165 for diphenyl methane C13H9+

not sure about the world class chemist....


Wow, I just saw your post edit. I am really fascinated how you pulled this substance within a few seconds that hundreds of people have been non-successfully speculating about for months.

My old teacher used to say: you don't need to know everything, but you should know whom to ask!

apparently I found the real experts here!

I am entirely unfamiliar with designer stimulants, so would you say that the described pharmacological effects would fit to diphenylmethylpyrrolidine?
 
diphenylmethyl pyrrolidine is the pyrrolidine analog of desoxypiradrol. and if it is anything like desoxypipradrol it is a very long lasting stimulant.

it is used industrially for resolving chiral things, CAS 119237-64-8 it has other names such as diphenyl-2-pyrrolidinyl-methane
see http://www.erowid.org/archive/rhodium/chemistry/pyrrolidinyl.html

the related diphenyl-2-pyrrolidinyl-methanol has been associated with cardiovascular toxicity, it differs by an OH group

http://jmt.pennpress.org/strands/jmt/pdfHandler.pdf?issue=20080403&file=20080403_167_169.pdf

I know nothing more about it, though I am sure others here can help fill in the gaps
 
many many thanks for your awesome and invaluable input!!!

Is diphenylmethylpyrrolidine actually being used for recreational purposes? i am somehwat surprised as I never in my life heard about it (but I also never searched for it either).

maybe there are people who could comment on the pharmacodynamics of diphenylmethylpyrrolidine and if it would be compatible with the effects / symptoms I described in my first post.
 
apparently I found the real experts here!

Vecktor is a world class chemist ;) which is why he gets shitty with all the high school students coming on here posting crap haha.

I was thinking DPMP (i.e. 2-diphenylmethylpiperidine) as soon as reading the symptoms you described, so the slightly more obscure diphenylmethylpyrrolidine makes perfect sense. We never tested this one but it is certainly available, just figured it would be like DPMP but not so good, sounds like the duration may be a bit shorter though which would be a plus.

DPMP doesn't spoil your appetite that much usually so there is probably something else in there producing the anorectic effect, or DPMPy is a stronger anorectic, or bodybuilders expecting anorectic effects feel the effects they expect...who knows.

Also while it may not be the case this time, designer analogues of modafinil are something I've been expecting to turn up for some time...
 
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Well in a surprising show of ethics they do list the ingredients including

"Proline Analog [Phenyl-pyrrolidinyltoluene]"

which I think can safely be assumed to be 2-[1-phenyl-1-(4-methylphenyl)methyl]pyrrolidine which would indeed be a novel analogue (or at least I've never heard of it before)
 
Well in a surprising show of ethics they do list the ingredients including

"Proline Analog [Phenyl-pyrrolidinyltoluene]"

which I think can safely be assumed to be 2-[1-phenyl-1-(4-methylphenyl)]pyrrolidine which would indeed be a novel analogue (or at least I've never heard of it before)

no the mass spectrum presented is wrong for that,the 4-methyldiphenylmethane fragment would be 14 AMU heavier, it is 2-(1,1,-diphenylmethyl )-Pyrrollidine with a bit of deliberate misnaming on behalf of the vendor.

I like the random but irrellevant proline refs though
 
can we not post glowing endorsements ripped from elsewhere when it doesn't add anything to the discussion, this stuff is one small step from a substance known to cause cardiovascular toxicity.

using stimulant anorectics is dumb.
 
Well in a surprising show of ethics they do list the ingredients including

"Proline Analog [Phenyl-pyrrolidinyltoluene]"

which I think can safely be assumed to be 2-[1-phenyl-1-(4-methylphenyl)methyl]pyrrolidine which would indeed be a novel analogue (or at least I've never heard of it before)


wow, that's really new.

here is what the product label shows at a large and popular online supplement store - the place from which most people actually purchase this product:


Here is a copy/paste of the label:

45 Capsules
Supplement Facts
Serving Size1Capsule
Servings Per Container45

Amount Per Serving % Daily Value

SX Proprietary Blend 500mg **
Cocoa Seed Concentrate (Standardized For Methylxanthines Equal To 100mg Caffeine/cap), AminoSlim-4*, Ginseng Root Extract (Standardized To 80% Ginsenosides), Aneurin DBE™ (Thiamine Disulfide Butyrate Ester), Acai Berry 4:1 Extract (Standardized To 10% Polyphenolic Antioxidants), Cha'de Bugre 10:1 Extract (Standardized For Purine Metabolites), *AminoSLim-4: A Combination Of Energyizing Amino Acids (Tyrosine, Tryptophan, Proline, And Carnitine) Specifically Enhanced To Assist In Significant Weight Loss.

** Percent Daily Values not established


However, I just checked the site of the company that produce this product and and saw the added "Proline Analog [Phenyl-pyrrolidinyltoluene]"

Apparently they have different versions of the label.....
 
wow, that's really new.

Yes, they probably read your thread on bluelight and changed the ingredients info on their website straight away so they can pretend its always said that. Do not underestimate the exposure of what you write on public forums like this.
 
can we not post glowing endorsements ripped from elsewhere when it doesn't add anything to the discussion, this stuff is one small step from a substance known to cause cardiovascular toxicity.

using stimulant anorectics is dumb.

I am sorry. these quotes were only meant to further support the notion that we are dealing with a substance that is of very unusual neural effects, at least for the average consumers of OTC products who use to regard caffeine and ephedrine as the holy grails of energizers.

I fully agree with you that the potential dangers of such substances can't be emphasized enough, and that it is highly unethical when a company does try to "hide" synthetic psychoactive substances in herbal dietary supplements with insufficent clinical research and safety data.
It was this concern that led me to this site in my search for more answers.
 
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Yes, they probably read your thread on bluelight and changed the ingredients info on their website straight away so they can pretend its always said that. Do not underestimate the exposure of what you write on public forums like this.


haha, i don't think so. but this kind of discussions and speculations on whether this product may be adulterated or not have been done on public forums for the last couple of months, so this company has certainly been aware that they are getting in the focus....

BTW: there is even a third version of the label that lists aniracetam as another ingredient. Apparently they are changing their labels every week....
 
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no the mass spectrum presented is wrong for that,the 4-methyldiphenylmethane fragment would be 14 AMU heavier, it is 2-(1,1,-diphenylmethyl )-Pyrrollidine with a bit of deliberate misnaming on behalf of the vendor.

I like the random but irrellevant proline refs though

excuse my ignorance, but does that mean that "Phenyl-pyrrolidinyltoluene" is just a misnamed diphenylmethyl-Pyrrollidine or is it an additional substance/ingredient in that product that is unrelated to the diphenylmethylpyrrolidine ?
and last question: does "Phenyl-pyrrolidinyltoluene" actually exist and if yes, does it possess known psychoactive effects?
 
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