MPT Inactive? Perhaps not

[Bal0n]

TiHKAL states the following:

The isomer of MIPT with a considerably less bunched up propyl group, N-methyl-N-propyltryptamine or MPT. This was made via the amide from indoleglyoxyl chloride and methylpropylamine, and reduction with LAH. MS (in m/z): C5H12N+ 86 (100%); indolemethylene+ 130 (8%); parent ion 216 (1%). Several human trials, up to twenty milligrams orally, showed no effects of any kind, so the activity, if there is any, is definitely less than that of MIPT. So the lumpiness of the isopropyl may be playing some role. There is no other way that is obvious of challenging this without adding more carbon atoms, and that would introduce another variable. This same decoration scheme has been used successfully in several other of the tryptamines in this story.

I was wondering, what is it that makes the isopropyl analogue of MPT more active? As far as I know there is no interaction between the 5-HT receptor and the alkyl tail. Or is there?

I know FnB drawed some pretty models with different compounds which nicely displayed the interaction with the serotonin receptor, could someone do that with MPT and MiPT as well? I'd be great .

 

[Jamshyd]

As we all know, plain DMT is assasinated by gut MAO. What seems to be less publicized is that DPT is also attacked by gut MAO, but somehow parts of the dose survive the attack and end up in the CNS.

DiPT, in contrast to DPT, is active orally (at least, reliably).

We know that MiPT is reliably active orally. Your quitation claims that MPT is inactive, and insinuates something about the isopropyl group. I guess it logical to say that the isopropyl group reliably protects the molecule against gut MAO.

Will someone fucking make PiPT already?? Geez, chemists are annoying!

 

[Bal0n]

How ignorant, I didn't even think of crossing the BBB or MAO affinity.

 

[hugo24]

PIPT,damned,something I always wanted to taste!Propyl and Isopropyl on that nitrogen,must be a winner,would be even orally active-and who knows it might have some auditory effects like DIPT.

Apropos MPT: at 86mg (freebase),there was some activity,duration 3h.Minor visual enhancement,but very erotic.Most remarkable (in hindsight) were the auditory effects/enhancement.Another one rotting on the shelf to be tasted again at higher doses...

All our theories are great,but then,why is DET orally active,much more that DPT ?And why is MET active? More so if compared to MPT? Is propyl just already on the wane?

 

[Jamshyd]

^ Thanks for the info in MPT (*is jealous*) haha.

But anyways, I think shulgin pointed out (agreeably) that there is a pattern in potency DMT < DET < DPT

I would like to know how much is DET affected by gut MAO. While DET is orally active at lower doses than DPT's oral activity, is it still very irratic in effect? It seems like it. Same goes to MET, but even less is known about this one.

 

[Morninggloryseed]

Jamshyd, why does DET seem inconsistent with oral dosages? I'm not trying to be argumentative, just wondering if I have missed a bunch of oral DET reports. From reading TIHKAL, DET seems fairly consistent in effect with oral dosages, at least more so than DPT.

 

[Jamshyd]

Well, I was actually wondering... didn't mean to make it sound like a statement. The thing with DET is that it seems to be very subtle in effect (I haven't tried either but I'd say it seems to behave similarly to MiPT in terms of subjective effects - at least when reading reports of both). The TiHKAL reports do seem consistent, however that consistency seems to be their ambiguity! Even that 400mg entry: "Too much." Ok, sorry to hear, but what do you mean...?

So I guess perhaps DET is somewhat irratic orally, but that is difficult to determine due to its subtle nature.

Of course, I could be wrong.

 

[yaesutom]

PIPT,damned,something I always wanted to taste!Propyl and Isopropyl on that nitrogen,must be a winner,would be even orally active-and who knows it might have some auditory effects like DIPT.

Apropos MPT: at 86mg (freebase),there was some activity,duration 3h.Minor visual enhancement,but very erotic.Most remarkable (in hindsight) were the auditory effects/enhancement.Another one rotting on the shelf to be tasted again at higher doses...

Interesting. Well I gave TMT / alpha-methyl-DMT a trial once so far, orally active although requires a kind of largish dose, I guess just because of that N,N-DMT part up there i automatically had some excitement that it might be similar to DMT (or psilocin, 5meo-dmt, etc, the 'dmt' feeling). Well actually I thought it was most like DiPT!

What I noticed the most was the auditory stuff going on, it lowered the pitch and screwed up harmonics in a DiPTish way but different, clearer, unique. So later I was punching in every known tryptamine that I know of, or that was in Tihkal, known to do a similar thing to audio into chemdraw buut i'll save that and post something in that DiPT thread,

So MPT does the audio thing? lowered pitch? etc..

 

[hugo24]

Interesting to hear the TNT ähem TMT has audioeffects.All these methyls,pressed there seem to be able to mimic at least partially DIPT.If you look Another way at it,its like an indol with an isopropyldimethylamine!

Unfortunately my notes on MPT are very short,but if I remember it correct it was more like a unique enhancement of sound,not unlike high dose MDMA (ever heard a moped drive by on MDMA? "häm äm äm äm with like pseudoechos attached on very (h)äm" if you get the drift.

re: PIPT:this seems an unknown compound in Scifinder.

 

[fastandbulbous]

^ Only on BL would you ever find a sentence linking MDMA, mopeds & ham!

 

[hugo24]

You mean I'm suffering heavy mental synästhesia 8(

I should add its all in german (but that does not help I guess)

In all seriousness,the thread should be renamed to "MPT activity?".It def. is not inactive.

 

[Jamshyd]

re: PIPT:this seems an unknown compound in Scifinder.

Thus the frustration in my first post about no one making PiPT .

PiPT would be N-propyl,N-isopropyltryptamine. It is actually mentioned in a table in the EiPT entry in TiHKAL with a note beside it that it hasn't been tested yet.