morphine makes my pain REALLY BAD sometimes

[Stephy]

Has anyone known of morphine making their pain worse sometimes, like really worse. beyond the fact that my pain is no where near helped. I don't know what to do. has anybody ever has this problem? sorry of where i put it, i couldn't find the opiod page.

 

[Quasimoto]

Paradoxical reactions from drugs are known to occur. Although, increased pain perception from morphine might be more of the rare ones.

What type of pain are you suffering from? Is this chronic pain? What conditions do you have?

Are you using pharmaceutical morphine prescribed by a doctor?

We need a little more info to help you out here.

 

[marcoman]

More info needed for sure, and hope you don't have bone cancer...as that's pretty bad pain..and often worse at night.

 

[Stephy]

i have a lot of low back pain. DDD, spondylitis, spondiosis, herniated and bulging disks, and they have been telling me i need a vertebral fusion surgery. my spine pops and not the good kind of pop people are always telling me it's fine... it's JUST AIR LEAVING and it doesn't hurt you... it's hurts like a son of a bitch and every time it pops it gets angrier and angrier feeling more and more inflamed!!! I admit to having a very sedentary life without enough exercise with weak core muscles. I've never been good at being out in the sun. i burn very easily so i never liked being out in it. less than an hour and i can burn very very badly and painfully. as you can imagine very painfully. I experience extraordinary pain as soon as i stand up. i believe from weak muscles. i take prescription morphine over a decade, but most of the time it's never given me real relief. it was 30mg xr time 4 day. with a 15 mg ir for breakthrough. now i have 25mcg fentanyl patch every 72hr with 30mg ir morphine x4a day. BUT NONE OF IT WORKS... just takes the edge off a bit. i hate it all!

 

[Keif' Richards]

@Stephy hey I'm sorry that you're struggling with this. Pain ruins people's lives. Often times we don't see it, as these people are stuck inside, in bed or on the couch. It's shitty. I really feel for you. This isn't the end of the road though. If this stuff is not working, there are plenty of other things to try. There are Opioids, partial agonists, Opioids like Tramadol that feature SNRI effects in addition to the Opioid agonism; there is a lot to try.

It's considered very rare, though there are people out there who are "immune" to the effects of Opioids. There are people who get little to no effect from any kind of exogenous Opioid. I don't fully understand the phenomenon. It's so rare that there is not a lot of information out there.

Have you tried muscle relaxers before like Carisoprodol (Soma) or Cyclobenzaprine (Flexeril)? I know a lot of people with severe back issues who benefitted from an adjunct medication to their Opioids. This could also be something like an antispasmolydic (reduces spasms).

Furthermore, a lot of people get actual, general pain relief from Gabapentinoids like Gabapentin (Neurontin) or Pregabalin (Lyrica). For someone with severe issues like yours, it would make more sense to just try Pregabalin first as it is stronger. This could be another useful adjunct to your Opioids.

I'm not sure if you use Cannabis or if you're able to where you live, but it can't hurt to throw some of that into the mix. Cannabis is one of the, all things considered, greatest pain medications known to man. People with severe pain can take highly concentrated oil and many people describe its usage as life-changing.

Factor in your NSAID regimen, maybe some Lidocaine patches and then you might feel well enough to bust out some very basic Yoga or whatever you like (I recommend Yoga 100%). Once you find your pain relief, make sure you use the time efficiently by applying yourself to lifestyle changes that might help with your pain.

So see, you have lots of different options right here in this thread. This is just a short list. There are all kinds of medications and treatments out there. It's my honest belief that you will get through this and get your quality of life back if you push yourself and stay dedicated. I know the couch is comfortable, but too much couch is the enemy.

If you have any questions or need any kind of help, you know where to find us.

 

[WellTram]

Take antihistamines or CNS stimulants except modafinil, which Is making pain worse because of H1 agonism. And tizanidine works great, benzos actually reduce opioid analgesia so don't except much from them

 

[ageingpartyfiend]

Take antihistamines or CNS stimulants except modafinil, which Is making pain worse because of H1 agonism. And tizanidine works great, benzos actually reduce opioid analgesia so don't except much from them

Can definitely attest to modafinil possibly making pain worse

I've noticed that a few times after consuming and wondered if the modaf was causing it

 

[ChemicallyEnhanced]

Has anyone known of morphine making their pain worse sometimes, like really worse. beyond the fact that my pain is no where near helped. I don't know what to do. has anybody ever has this problem? sorry of where i put it, i couldn't find the opiod page.

Yes. Opioid-induced hyperalgesia is a thing. Basically, opioids start making you extra-sensitive to pain, so make your pain worse.
You might find that by reducing/stopping your Morphine, overall your pain levels get BETTER.
But, obviously, if it's something you take every day, don't just suddenly stop taking it or you'll go into withdrawal.

 

[Stephy]

@Stephy hey I'm sorry that you're struggling with this. Pain ruins people's lives. Often times we don't see it, as these people are stuck inside, in bed or on the couch. It's shitty. I really feel for you. This isn't the end of the road though. If this stuff is not working, there are plenty of other things to try. There are Opioids, partial agonists, Opioids like Tramadol that feature SNRI effects in addition to the Opioid agonism; there is a lot to try.

It's considered very rare, though there are people out there who are "immune" to the effects of Opioids. There are people who get little to no effect from any kind of exogenous Opioid. I don't fully understand the phenomenon. It's so rare that there is not a lot of information out there.

Have you tried muscle relaxers before like Carisoprodol (Soma) or Cyclobenzaprine (Flexeril)? I know a lot of people with severe back issues who benefitted from an adjunct medication to their Opioids. This could also be something like an antispasmolydic (reduces spasms).

Furthermore, a lot of people get actual, general pain relief from Gabapentinoids like Gabapentin (Neurontin) or Pregabalin (Lyrica). For someone with severe issues like yours, it would make more sense to just try Pregabalin first as it is stronger. This could be another useful adjunct to your Opioids.

I'm not sure if you use Cannabis or if you're able to where you live, but it can't hurt to throw some of that into the mix. Cannabis is one of the, all things considered, greatest pain medications known to man. People with severe pain can take highly concentrated oil and many people describe its usage as life-changing.

Factor in your NSAID regimen, maybe some Lidocaine patches and then you might feel well enough to bust out some very basic Yoga or whatever you like (I recommend Yoga 100%). Once you find your pain relief, make sure you use the time efficiently by applying yourself to lifestyle changes that might help with your pain.

So see, you have lots of different options right here in this thread. This is just a short list. There are all kinds of medications and treatments out there. It's my honest belief that you will get through this and get your quality of life back if you push yourself and stay dedicated. I know the couch is comfortable, but too much couch is the enemy.

If you have any questions or need any kind of help, you know where to find us.

sorry. i hurt too much to read long messages. i was only able to write a long one because i used to talk to text over a12 hour period to write mine. I've tried everything medial branch blocks cortisone shots nerve ablations Chiropractic care acupuncture Gabapentin muscle relaxers anti-depressants you name it I've tried it! Heat belts cold packs muscle rubs massage digging into a tennis ball or self massage until I had bruises. I've tried every opiate out there and every muscle relaxer. I've also tried every antidepressant out there and mood stabilizers. Physical therapy. Don't think I've tried Tramadol but I've tried Darvocet hydrocodone Dilaudid oxycodone hydromorphone and everything else I can't think of right now. I've tried and can't stand Gabapentin tried to tell the doc that it didn't do anything for me I don't have nerve pain but he said I had to try it anyway just to exhaust our efforts. I have tried Lyrica or pre-gabapentin as well but it wouldn't be a bad idea to try it again I actually was thinking about that already. I even went back to dried smoking pot it didn't help either. I've done the yoga I've done the motion is lotion. Unfortunately TV and the internet are the only things that help me to try and put my pain out of my head and actually help with the pain. I'm even doing this virtual reality physical therapy at home where this company sent me a VR headset and I try using that that actually helps a little bit but because I'm got something entertaining you know that I don't have to go and use up my energy and helps me forget about my pain a little. However like you said too much couch is not a good thing and although playing on my phone helps me relieve some of my pain there's no way I can stay on the couch all the time and not be able to pay my bills. LOL I also have chronic fatigue syndrome and facial blindness so I don't have a lot of people in my life. Because I can't remember faces never been able to since I was a kid never knew that wasn't normal either. So no there really aren't very many options out there for me anymore as I've already used them all

** I forgot about NSAIDS they've given me bleeding duodenal ulcers so I can't use them too much not that they help anyway

 

[Stephy]

Yes. Opioid-induced hyperalgesia is a thing. Basically, opioids start making you extra-sensitive to pain, so make your pain worse.
You might find that by reducing/stopping your Morphine, overall your pain levels get BETTER.
But, obviously, if it's something you take every day, don't just suddenly stop taking it or you'll go into withdrawal.

Yeah I've read about that and that's exactly what I was worried about

 

[Stephy]

Can definitely attest to modafinil possibly making pain worse

I've noticed that a few times after consuming and wondered if the modaf was causing it

Can definitely attest to modafinil possibly making pain worse

I've noticed that a few times after consuming and wondered if the modaf was causing it

I don't know what that is tell me about it

 

[Stephy]

Take antihistamines or CNS stimulants except modafinil, which Is making pain worse because of H1 agonism. And tizanidine works great, benzos actually reduce opioid analgesia so don't except much from them

Benzos are probably the only thing I don't do. I can't use Tizanidine and knocks me on my ass puts me right to sleep!

 

[Stephy]

@Stephy hey I'm sorry that you're struggling with this. Pain ruins people's lives. Often times we don't see it, as these people are stuck inside, in bed or on the couch. It's shitty. I really feel for you. This isn't the end of the road though. If this stuff is not working, there are plenty of other things to try. There are Opioids, partial agonists, Opioids like Tramadol that feature SNRI effects in addition to the Opioid agonism; there is a lot to try.

It's considered very rare, though there are people out there who are "immune" to the effects of Opioids. There are people who get little to no effect from any kind of exogenous Opioid. I don't fully understand the phenomenon. It's so rare that there is not a lot of information out there.

Have you tried muscle relaxers before like Carisoprodol (Soma) or Cyclobenzaprine (Flexeril)? I know a lot of people with severe back issues who benefitted from an adjunct medication to their Opioids. This could also be something like an antispasmolydic (reduces spasms).

Furthermore, a lot of people get actual, general pain relief from Gabapentinoids like Gabapentin (Neurontin) or Pregabalin (Lyrica). For someone with severe issues like yours, it would make more sense to just try Pregabalin first as it is stronger. This could be another useful adjunct to your Opioids.

I'm not sure if you use Cannabis or if you're able to where you live, but it can't hurt to throw some of that into the mix. Cannabis is one of the, all things considered, greatest pain medications known to man. People with severe pain can take highly concentrated oil and many people describe its usage as life-changing.

Factor in your NSAID regimen, maybe some Lidocaine patches and then you might feel well enough to bust out some very basic Yoga or whatever you like (I recommend Yoga 100%). Once you find your pain relief, make sure you use the time efficiently by applying yourself to lifestyle changes that might help with your pain.

So see, you have lots of different options right here in this thread. This is just a short list. There are all kinds of medications and treatments out there. It's my honest belief that you will get through this and get your quality of life back if you push yourself and stay dedicated. I know the couch is comfortable, but too much couch is the enemy.

If you have any questions or need any kind of help, you know where to find us.

I've done the Lidocaine patches... they don't do a damn thing for my lower back but when my middle back starts having electric shock extreme pain some Biofreeze and a bunch of those is the one of the few things that does help. But it's my low back that is an excruciating pain all the time my middle back only hurts when I overdo myself

 

[WellTram]

Can definitely attest to modafinil possibly making pain worse

I've noticed that a few times after consuming and wondered if the modaf was causing it

Yes it Is. I take it in high doses in seasons of nonstop town news like 20 posts + marketing....It would be ultimate stimulant but it Is not like they say, Its acting also on peripheral parts of our body, causing same side effects as caffeine, amphetamines ( vasoconstriction, headaches, hot/cold feeling, paranoia). And i need 3x more of every downer while on it including opioids but still not enought to counteract that modafinil-induced pain....

 

[WellTram]

Benzos are probably the only thing I don't do. I can't use Tizanidine and knocks me on my ass puts me right to sleep!

Its great for fast sleep induction. But it Is very short acting

 

[Keif' Richards]

@Stephy that's really a sad situation. I read through all of the medications you've listed. You've definitely been through it. I'll try to make this shorter for you, so don't take it the wrong way if I sound abrupt.

- Screen Time is fine, just make sure you take breaks throughout the day. 10 hours straight of Youtube or Social Media or whatever tends to make people feel worse. It's like a drug. Lights, bells, whistles, excitement. Just like the guys who play slot machines.

- Pregabalin it sounds like you might have some reserved hope for Pregabalin. I recommend trying it. I don't think it's the key to your issue. Ideally we just want you with more energy and motivation to do stuff other than your screens which could open up your life

- Otherwise, I would recommend trying to get involved with research studies for pain. I know this might sound like a lot, but you can try to locate the studies that are centered around novel painkillers. Believe it or not, they say they're on the verge of having some new options soon. If everything else has failed, this could be the longshot that helps you.

We are here to help you with any questions and we're also here to support you. I don't really deal with chronic pain, but I know misery and hating being alive. I have felt in similar ways. I thought a way out for me was impossible. It wasn't and the same is true for you. You can find happiness and contentment even with your issues, I know it.

 

[rentedbythehour]

And tizanidine works great, benzos actually reduce opioid analgesia so don't except much from them

Just a side note here. Tizanidine actually made me suicidal. I'm not sure if it was a reaction with other meds I take but I'm positive it was tizanidine. I take cymbalta, which is also used for chronic pain, was on Ativan and various migraine meds. I was switched to Klonopin and methocarbamol (robaxin). Ever since then, I've been fine.

I used to take oxy. I was prescribed it for close to 20 years. I didn't have any negative side effects from it for probably 15 of those years. Once I started feeling more pain than I had before, I stopped taking it. I feel so much less pain, just in general since getting off of it.

It is also possible that your tolerance level has reached a plateau. There are ways you can reset it so the meds work better for you but I would talk to your DR about that. There are also more options than ever about treating chronic pain without any kind of opiates.

I cannot stress this last point enough. If you do end up getting surgery, please research your Dr. How many of these procedures has he/she done? Is it a neurosurgeon or an orthopedic back surgeon? Def go with a neurosurgeon. What's the success rate? Which levels would be fused? How will that limit mobility after? As someone who worked in the operating room for years, did many of these surgeries, sometimes people come out worse than they were when they went in. I can say the best results happen with people that have a positive frame of mind when they undergo surgery. They have plans and goals about what comes next in life. They always seem to recover quicker and do better overall.