Hello.
I read whole WHO documents about tramadol, oxycodone, metabolites and many research that provided this rusults:
Tramadol is low potency MOR agonist with Ki = 2400nM.
However, if u are able to metabolize tramadol into O-DSMT (by cyp2d6),
most of metabolizers convert 15-20% of ingested tramadol into O-DSMT which is full MOR agonist with Ki = 11 nM.
Oxycodone is MOR agonist with Ki = 18 nM.
This means, tramadol ( metabolized into O-DSMT) is even more potent than oxycodone and this combined with it's longer duration of action, added monoaminergic properties can be the cause of tramadols horrible withdrawal symptoms.
Also, even less than 50mg (37,5mg) , sometimes cause vomiting for new users due to rapid raise in serotonine.
The only reason they marketed tramadol as much less addictive, is longer time to take effects = no rush. This is because metabolizing tramadol into O-DSMT take some time but in form of oral drops, i feel it in 30 minutes. In IR tablets in 1 hour.
But many, many years ago they knew this is potent synthetic opioid with SNRI and other added properties.
Just little bit of i formation.
Be safe and and have a nice day.
I read whole WHO documents about tramadol, oxycodone, metabolites and many research that provided this rusults:
Tramadol is low potency MOR agonist with Ki = 2400nM.
However, if u are able to metabolize tramadol into O-DSMT (by cyp2d6),
most of metabolizers convert 15-20% of ingested tramadol into O-DSMT which is full MOR agonist with Ki = 11 nM.
Oxycodone is MOR agonist with Ki = 18 nM.
This means, tramadol ( metabolized into O-DSMT) is even more potent than oxycodone and this combined with it's longer duration of action, added monoaminergic properties can be the cause of tramadols horrible withdrawal symptoms.
Also, even less than 50mg (37,5mg) , sometimes cause vomiting for new users due to rapid raise in serotonine.
The only reason they marketed tramadol as much less addictive, is longer time to take effects = no rush. This is because metabolizing tramadol into O-DSMT take some time but in form of oral drops, i feel it in 30 minutes. In IR tablets in 1 hour.
But many, many years ago they knew this is potent synthetic opioid with SNRI and other added properties.
Just little bit of i formation.
Be safe and and have a nice day.
