Modern SERT/DAT releasing compounds + Comparison

[Leprechaun]

In the last 15 years, it's been more and more common to see a number of compounds released which can replace the effects of MDMA as a popular recreational and therapeutic compounds. Most of these are benzo-furans, which instead of a Methylene Dioxide ring, there is a Furan ring.

These compounds all have similar properties but people do notice different effects, primarily duration.

A direct comparison of non-subjective effects on various neural substrates has been done.

Here is a great study which shows a direct comparison between the many new compounds available : https://pmc.ncbi.nlm.nih.gov/articles/PMC4500375/


CONCLUSION OF STUDY

Benzofurans are monoamine transporter blockers and monoamine releasers, similar to MDMA, but they also interact with 5-HT receptors. This mechanism of action predicts psychotropic and clinical toxicological effects that are similar to the entactogen MDMA but with additional hallucinogenic properties. The benzodifuran 2C-B-FLY is a potent hallucinogen, probably also associated with a risk for clinical complications related to vasoconstriction (e.g. ischaemia and hypertension). Although structure–activity relationships exist, the present study showed that structurally very similar compounds may exhibit distinct pharmacological profiles, illustrating the need for pharmacotoxicological profiling of each novel psychoactive substance.