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Dissociatives Methylenedioxyphencyclidine ?

If I look at the Swiss Target Prediction i'll let it go. Doesnt look favorable.

We all feel emotional about MDMA but emotion shouldnt guide molecular design

NMDA antagonism isnt even in the top-10 of predicted effects.
 
Medicinal chemists generally make better guesses than most of those tools and physical assays are always needed for confirmation

If there are positive reports for activity of a compound I would never disregard it just based on a computational tool
 
someguyontheinternet said:
Medicinal chemists generally make better guesses than most of those tools and physical assays are always needed for confirmation

If there are positive reports for activity of a compound I would never disregard it just based on a computational tool
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Kinda synonymous to how machines took over manual measurement, the machine broke down. And one almost retired old skool guy. Who was the one doing it manual before that machine came. Was the only one in the whole company who stil had the knowledge how to do it by hand.

So knowledge almost lost, would the previous manual instrument not have been kept all the time. It would have been an other scenario. Waiting for repair or a new bought machine.

Same era my Grandfather lived. who would reproduce any broken part, of any machine at the place he worked by hand.
Precise to mm, that was his job.

edit : is this btw why so many worthless RC were created and produced/ sold. Where these based on computer models orso, things like 4-BMAR, 3-MMA or DesMethylFlunitrazepam [might be personal physiology] all seemed inactive.
Ok and offcourse there is the marketing value of the name. Which with this compound also is part of making 💲, ...-PCP. Saw a doc on PCP and someplace in US its the DOC, and the effects of reasonable doses seemed pretty euphoric.

But there is no reason this compound will act (a bit) the same way [except when its a pro-drug].
Otherwise past learned me its very unpredictable.
 
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I think many times medicinal chemists aren't even involved and they just start slapping functional groups here and there, that's why we get so much useless junk. Some companies do have medchem departments like that one lab in Europe I presume but other mass producers are just trying to move compounds
 
Asante said:
If I look at the Swiss Target Prediction i'll let it go. Doesnt look favorable.

We all feel emotional about MDMA but emotion shouldnt guide molecular design

NMDA antagonism isnt even in the top-10 of predicted effects.
Click to expand...
Hello

Can confirm this compound is active and fantastic! Not only that but the 3,4-MD substitution is incredibly fruitful for other amines. I've found its produced delightful results with 3,4-MD-PCiPr and 3,4-MD-PCPr. Reports and notes for those will come with time (so many novel ACH's so little time...)

But even beyond my qualitative experience, Jason Wallach made a handful of 3,4-MD subbed ACH's for his dissertation and all are quite active and high affinity in vitro.

Something I will say for the 3,4-MD ACH's that I've observed across the existing amine moieties is that they are quite unforgiving- the experience effortlessly ventures into the territory of being intense and unmanageable, with racing thoughts and unnavigable amplifications of certain streams of thought, often looping into paranoia or fixation. In this regard they can be quite therapeutic when harnessed with intention, but they can just as easily go very wrong. 3,4-MD-PCP has given me intense panic attacks fixation on bizarre sexual shame (separate from the experience I reported on), 3,4-MD-PCiPR has sent me into intense paranoid episodes about jeopardizing my job, or that one of my closest friends was plotting against me- but it has also offered glowing sociable experiences where I've made wonderful connections with others. These don't seem to be drugs of casual use, and others who have experienced them have reported similar- unfettered delight and insight but sometimes harrowing dysphoric trials- they are incredibly sensitive to set and setting, moreso than any other hallucinogens I have explored really. I have a lot on my plate but I hope to generate more detailed data and reports on 3,4-MD-PCiPr and 3,4-MD-PCPr in the near future.

I also have 3,4-MD-PCDE lying around- intranasally it's just a stimulant, but it appears that tertiary amines with arylcyclohexylamines metabolize into equal portions of the corresponding secondary amine- so perhaps 3,4-MD-PCDE is a prodrug to 3,4-MD-PCE, which I've heard is wonderful in its own right. I need to experiment with other routes of administration for this.

Also STP is notoriously unreliable for NMDA antagonists. Don't let it kill your hype!
 
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