Right now I've been really short on my supply of opiates. I'm about to get a 10mg methadone that I'm going to IV. I have NEVER taken methadone prior, and this a single dose one time thing. I know for fact I'm getting a whole bunch of dilaudid tomorrow. My question is if I take this 10mg dose IV right now at 7:30 will it significantly interfere with my 12mg dose of dilaudid tomorrow? I understand there is a blocking effect but this is a one time thing and I'm IVing it which I believe shortens the half life somewhat which is 36-55 hours. Does anyone have experience similar to my situation.