Meth & GHB Combo, Dosage Question?

[KattyKorner]

I want to start off by saying I know that mixing a stimulant with a downer is bad. I'm also just asking theoretically because the combo sounds good, but also because I'm just curious. Not "swim" type stuff, genuinely just curious

But meth obviously lasts a long time. And ghb doesn't, and is relatively safe as long as one isn't using ANY other downers, and uses reasonable doses.

So I guess the main question would be "if someone uses meth, and takes a dose of ghb, could they take a heavy front dose, say, 3 grams, maybe more, would that just make one pass out, or would the meth keep them awake, but just terribly sloppy?"

Not looking to justify this usage, or dosage. More asking for the question behind the question "How well, and in what manner, would meth allow larger doses of ghb, and how would the larger doses affect one, in general"

Just had the thought of one day trying both, and trying the ghb before hand to get an idea of dosing, but using both raised questions for me that I wanted answered.

Thank you!

 

[axe battler]

Yeah the meth would probably keep you awake at higher doses.
Thing is that for me, doses just below those at which I pass out made me feel quite shitty and make me twitch and my muscles sore, and this feature would be even worse on methamphetamine. I'd adhere to the same doses as those you'd take sober.
Also, never done ghb, but have done GBL a lot, and this is apparently pretty identical. This seems to happen with all gabapentinoids, like phenibut and pregabalin, so I can imagine ghb would be no exception.

 

[Kizaru]

I want to start off by saying I know that mixing a stimulant with a downer is bad. I'm also just asking theoretically because the combo sounds good, but also because I'm just curious. Not "swim" type stuff, genuinely just curious

But meth obviously lasts a long time. And ghb doesn't, and is relatively safe as long as one isn't using ANY other downers, and uses reasonable doses.

So I guess the main question would be "if someone uses meth, and takes a dose of ghb, could they take a heavy front dose, say, 3 grams, maybe more, would that just make one pass out, or would the meth keep them awake, but just terribly sloppy?"

Not looking to justify this usage, or dosage. More asking for the question behind the question "How well, and in what manner, would meth allow larger doses of ghb, and how would the larger doses affect one, in general"

Just had the thought of one day trying both, and trying the ghb before hand to get an idea of dosing, but using both raised questions for me that I wanted answered.

Thank you!

Mixing downers with stims being bad for your heart is mostly Bull shit in my opinion . I did ghb with stims for years and it only has a positive effect on my heart (lowering heart rate and bp) xyrem (pharma ghb) is even prescribed combined with adderal fda approved .

 

[ninjapirateroberts]

I don't know about GHB, but I have seen some ADHD people take Xanax (alprazolam) 0.5mg - 1mg together with their stimulant drug and say they have a better experience that way. Personally, I believe taking CNS depressant drugs together with stimulants would "dumb down" the therapeutic effects of stimulants since they counteract (same with taking L-Theanine with stimulants, some people say it dumbs down stimulants, so they avoid that combo).

I only take alprazolam as an emergency remedy for a panic attack once in a while. I don't take any downers with stimulants (I used to take alprazolam 1mg to sleep due to acute stimulant-induced insomnia, but I've discontinued alprazolam usage).

Maybe take staggered doses than one large dose because taking one larger dose might over-saturate membrane proteins that are involved mediated transport of the drug.

 

[ninjapirateroberts]

Mixing downers with stims being bad for your heart is mostly Bull shit in my opinion . I did ghb with stims for years and it only has a positive effect on my heart (lowering heart rate and bp) xyrem (pharma ghb) is even prescribed combined with adderal fda approved .

I think that is one of the medical "dogmas" that taking for example Xanax with Adderall is "bad for your heart" because "one is telling heart to speed up and the other is telling heart to slow down". It is like the medical textbook dogma of unopposed α-receptor stimulation when mixing β-blockers with stimulants for people with hypertension. Many doctors call the dogma of "unopposed α-receptor stimulation" as complete bullshit since the actual evidence for that is still lacking on studies.

 

[ninjapirateroberts]

But benzo use does seem to affect the mortality rate:

Patterns of Benzodiazepine Use and Excess Risk of All-Cause Mortality in the Elderly: A Nationwide Cohort Study - PubMed

<p>These findings confirm the existence of an excess risk of mortality associated with benzodiazepine use and provide pattern- and age-specific estimates. Higher risks were observed for patients aged < 80 years, short-term use, or chronic use recently interrupted. If the two latter can relate to...

pubmed.ncbi.nlm.nih.gov

Association Between Benzodiazepine Use With or Without Opioid Use and All-Cause Mortality in the US

This cohort study uses data from the National Health and Nutrition Examination Surveys to evaluate whether benzodiazepine use, with or without opioid use, is associated with increased all-cause mortality relative to the use of low-risk antidepressants.

jamanetwork.com

 

[Kizaru]

I don't know about GHB, but I have seen some ADHD people take Xanax (alprazolam) 0.5mg - 1mg together with their stimulant drug and say they have a better experience that way. Personally, I believe taking CNS depressant drugs together with stimulants would "dumb down" the therapeutic effects of stimulants since they counteract (same with taking L-Theanine with stimulants, some people say it dumbs down stimulants, so they avoid that combo).

I only take alprazolam as an emergency remedy for a panic attack once in a while. I don't take any downers with stimulants (I used to take alprazolam 1mg to sleep due to acute stimulant-induced insomnia, but I've discontinued alprazolam usage).

Maybe take staggered doses than one large dose because taking one larger dose might over-saturate membrane proteins that are involved mediated transport of the drug.

I am a very experienced ghb user, here in Holland its pretty common . I have used ghb for almost 10 years now and i have always combined it with stims (amps) . The only warning with stims and g which is even stated on official addiction clinic site is that when the speed wears off the ghb can suddenly overwhelm and make you nodd while before on stims you could take double the dose . This is very easy avoidable if you are not a complete moron obviously . Benefits of taking ghb with adderal/dex/meth they go hand in hand and is extremely synergising . I can still eat ALOT while tweaking which for most people is impossible . One of the main reason speed can fuck you up is because people can't and won't eat while doing meth . All side effects and damage is so much reduced because i simply eat all the way till i go sleep . Also if you are awake for to long like over 72 hours , there is no anxiety if your on g . And even when being awake 3 days i sleep couple of hours and get deep sleep wake up and feel fine . Reduced heart rate and bp while being on stims . I can easily go to gym and do exercise with my heart rate not going above 100 or 110 . And this doesnt feel bad for the heart at all , it makes the damage from stims much "less" . I can only say i speak about experience and i think i can say a positive thing about it after having done it for years and years . Also here in Holland everyone combines g with stims , i almost don't know anyone that doesn't . G is 100% made for speed , specifically speed and not so much cocaïne . Alcohol and cocaïne is better then g and cocaïne , while g is way way better with speed compared to coke . And don't let me even get started about the libido benefits . G even works as viagra , with stims you have high libido but stim dik , problem solved with ghb instant . G is king , very abusable and addictive so keep this in mind . Unfortunately not many people have experience with it . To much bs with dosing ghb is "incredible" dangerous which isn't true at all . There is "alot" of misconception about oding on ghb . Yes it can be dangerous if combined with other cns depressants for real . But on its own its actually a very superior sleep aid , the od dose is far above a heavy "sleep dose" so you either have to intentionally take extreme high dose other wise you will pretty much always fall asleep if you accidentally would take to much long before you reach od doses . Also what most people don't know ghb is since 2002 fda approved for the treatment of narcolepsy called Xyrem which can be used from age 7 . This obviously removes alot of horror stories about ghb in my opinion..

 

[Kizaru]

I think that is one of the medical "dogmas" that taking for example Xanax with Adderall is "bad for your heart" because "one is telling heart to speed up and the other is telling heart to slow down". It is like the medical textbook dogma of unopposed α-receptor stimulation when mixing β-blockers with stimulants for people with hypertension. Many doctors call the dogma of "unopposed α-receptor stimulation" as complete bullshit since the actual evidence for that is still lacking on studies.

I think that is one of the medical "dogmas" that taking for example Xanax with Adderall is "bad for your heart" because "one is telling heart to speed up and the other is telling heart to slow down". It is like the medical textbook dogma of unopposed α-receptor stimulation when mixing β-blockers with stimulants for people with hypertension. Many doctors call the dogma of "unopposed α-receptor stimulation" as complete bullshit since the actual evidence for that is still lacking on studies.

I know with most things in practice its the complete opposite. Opioides and stims , benzo's stims, ghb stims . The only thing i have heard it might rlly be bad is a speedball , i don't know if this is true ? It probably also mostly has to do with the amount of both . If you take high doses of both its probally different then smaller doses .
And benzo's supposed to be bad with stims is utter bs because a normal amount of benzo's have zero cns depressant effects ..

 

[ninjapirateroberts]

I am a very experienced ghb user, here in Holland its pretty common . I have used ghb for almost 10 years now and i have always combined it with stims (amps) . The only warning with stims and g which is even stated on official addiction clinic site is that when the speed wears off the ghb can suddenly overwhelm and make you nodd while before on stims you could take double the dose . This is very easy avoidable if you are not a complete moron obviously . Benefits of taking ghb with adderal/dex/meth they go hand in hand and is extremely synergising . I can still eat ALOT while tweaking which for most people is impossible . One of the main reason speed can fuck you up is because people can't and won't eat while doing meth . All side effects and damage is so much reduced because i simply eat all the way till i go sleep . Also if you are awake for to long like over 72 hours , there is no anxiety if your on g . And even when being awake 3 days i sleep couple of hours and get deep sleep wake up and feel fine . Reduced heart rate and bp while being on stims . I can easily go to gym and do exercise with my heart rate not going above 100 or 110 . And this doesnt feel bad for the heart at all , it makes the damage from stims much "less" . I can only say i speak about experience and i think i can say a positive thing about it after having done it for years and years . Also here in Holland everyone combines g with stims , i almost don't know anyone that doesn't . G is 100% made for speed , specifically speed and not so much cocaïne . Alcohol and cocaïne is better then g and cocaïne , while g is way way better with speed compared to coke . And don't let me even get started about the libido benefits . G even works as viagra , with stims you have high libido but stim dik , problem solved with ghb instant . G is king , very abusable and addictive so keep this in mind . Unfortunately not many people have experience with it . To much bs with dosing ghb is "incredible" dangerous which isn't true at all . There is "alot" of misconception about oding on ghb . Yes it can be dangerous if combined with other cns depressants for real . But on its own its actually a very superior sleep aid , the od dose is far above a heavy "sleep dose" so you either have to intentionally take extreme high dose other wise you will pretty much always fall asleep if you accidentally would take to much long before you reach od doses . Also what most people don't know ghb is since 2002 fda approved for the treatment of narcolepsy called Xyrem which can be used from age 7 . This obviously removes alot of horror stories about ghb in my opinion..

Btw, to clarify, I was talking about therapeutic stimulant use for ADHD/ADD, not someone who uses recreationally because recreational users are most likely to use way higher doses that are out of the therapeutic index bounds for both meth and d-amph, which is a totally different case.

 

[Kizaru]

Btw, to clarify, I was talking about therapeutic stimulant use for ADHD/ADD, not someone who uses recreationally because recreational users are most likely to use way higher doses that are out of the therapeutic index bounds for both meth and d-amph, which is a totally different case.

Sorry i kinda used drugs , so i type fast and think fast . Yeah i understand , but even with recreational doses there is nothing going , so with therapeutic doses i don't rlly believe its bad while simultaneously being prescribed in combination .