Cocaine Meth and tolerance

[blight12]

Has anybody had the experience of a meth binge for 3 days blasting your tolerance for other stims out of the water?

I have had a great relationship with methcathinone usage daily without any increase in tolerance and now after 1 first time meth binge (1g "shards" over 3 days) the mcat does nothing even 4 days after the meth ended. How long until the tolerance gets back to normal?

Not all stims are insufflated only.

 

[Venrak]

The reasons for cross tolerance between stims with different methods of action are basically a combination of DAR downregulation and DA depletion. We can't give you an exact time frame, but waiting at least a week will allow for increased effects.

 

[tricomb]

I have never experienced what you're talking about, but chemically it would make sense that you'd feel drained after all that release of reward systems.

 

[NeighborhoodThreat]

I've noticed cross-tolerance across amphetamines, cocaine, and methylphenidate. Methamphetamine is even more potent than regular old amphetamine and I imagine that a full-on three day binge would drain your dopamine (and probably NE and serotonin) levels considerably. You may feel something from the cocaine, but, as others have said, its probably best to wait a while and allow your body to recover before doing more strong stimulants. Even though the methods of action of amphetamine/methamphetamine and cocaine are different, they still work with the same group of neurotransmitters.