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Melatonin potentiating psychedelics?

fourty6andtwo

fourty6andtwo

Bluelighter
Joined
Dec 16, 2006
Messages
20
Anyone ever tried taking a few melatonin tabs with some other tryptamine...I know its not psychoactive on its own but might it have synergistic effects with other tryps? hmm...
 
not too sure about other people but melatonin gives me extremely pronounced sleepyness, great as a sleep-aid as i tend to be able to wake up very easily but i'm not too sure about combining with other tryps.. maybe it takes on another effect beyond relaxation?
 
i also take it every night to help me sleep.

melatonin has been known to cause very strange, vivid dreams in higher amounts. i've also had this effect in the past. i suppose a "synergy" is POSSIBLE, but i'd imagine it's not probable...
 
If I try to take in on the tail end of a trip to sleep I find it has the opposite effect and slightly intensifies the trip.

I've also noticed a bit of synergy with pot.
 
Yes definatly at the end of a trip, I usually have to help it along with a few shots. But Always a winner for that much needed sleep after my brain has it's workout. My sweet spot is 9mg of melatonin. But it seems as though it loses it's magic after a while.
 
When I first started doing acid I thought I'd read somewhere that it could help with the body load i.e. anxiety from electric spinal sensations. I took some and I had little trouble so I ascribed the changed effects to the melatonin. Later once I went to a tripping party and handed out a couple mgs of melatonin (they were 0.1 mg pills) so these guys were looking at the pile like: dude have you even taken this many??? But the stuff is pretty harmless and the pill dosage so so tiny. We had a very open and truthful group trip but we decided the melatonin did nothing. So now I'm gonna stick with:
Yes, it works! As a placebo!

(not talking about any melatonin effects on sleep, that's a whole other story i.e. its proven to help with our biocycle)

And I never took as much as 9 mg, maybe that could indeed amount to something
 
Actually in my experience Melatonin CAN potentiate some tryptamine and phenethylamine psychedelics but you should only start using the Melatonin a few nights in advance of a trip never take the melatonin and psychedelic at the same time. Over the summer I'd noticed a few posts to forums where people were talking about preloading on really high doses of melatonin for 5-7 nights as a way to make a 2ce trip stronger and longer lasting in effect. They were talking about taking doses as high as 24 mg of Melatonin nights before a planned trip. The guy who started the thread said the best approach was to start taking like 3-6 mg of melatonin at night 5-7 days before you trip. And to each night increase your dosage by 3 or 6 mg working your way up to 21-24 mg of Melatonin the night before your trip.

So a friend of mine tried the melatonin preloading thing on a few occasions before doing 2ce and he raved about the results. He swore his trips were a lot longer, more intense and visual the times he preloaded with Melatonin.

So eventually I had to see for myself what all this melatonin preloading could do to a phenethylamine or tryptamine psychedelic experience. So I tried preloading on melatonin at night for a few nights before a Hawaiian Baby Woodrose trip. The trip did in fact seem more intense, visual and long lasting than usual. I've since then tried the melatonin/woodrose combo a few more times with good results. Maybe I'm just getting placebo but whatever it is it sure feels like a better trip to me.
 
And I never took as much as 9 mg, maybe that could indeed amount to something.
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I've never taken that much either, but luckily its impossible to OD on melatonin (unlike many sleep aids). Volunteers were given 6 grams nightly for a month and stomach discomfort and sleepiness were the only side effects.

There is no doubt melatonin works though, it puts 6+ billion people to sleep every night, the trick is finding the sweet spot with supplements. Thats why there's such a wide range of dosages available. I prefer 1mg or 3mg pills myself.
 
I took 21mg of melatonin about 45min before MDMA to help with sleep later and for its antioxidant effects. The MDMA dose was 48mg plugged. This was more intense and more psychedelic than a 150mg oral dose. I don't know if the melatonin potentiated the MDMA or it was something else that caused it. I used piracetam earlier in the day and drank a small amount of wine right before plugging the MDMA.

I'll try this again eventually, and see if it can be repeated. I really doubt melatonin would cause such a drastic increase in MDMA's effectiveness.
 
Tryptamine*Dreamer said:
I took 21mg of melatonin about 45min before MDMA to help with sleep later and for its antioxidant effects. The MDMA dose was 48mg plugged. This was more intense and more psychedelic than a 150mg oral dose. I don't know if the melatonin potentiated the MDMA or it was something else that caused it. I used piracetam earlier in the day and drank a small amount of wine right before plugging the MDMA.

I'll try this again eventually, and see if it can be repeated. I really doubt melatonin would cause such a drastic increase in MDMA's effectiveness.
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Melatonin definitely potentiates all psychedelics, and does it well; if you want to prove yourself of how powerful Melatonin is. Take approximately 3-4mg with some Grapefruit juice and wait about 2 1/2 - 3 hours.

Smoke about .5 of a gram, more if you prefer (Blunt, Bong, Joint) of some high quality cannabis, particularly a sativa strain. For a brief moment you will be so confused, because the high will be greatly enhanced and on so many different aspects. As the instant body rush begins to curl over your body like a wave. First, you will be sitting there wondering how you're seeing some nice OEV's and when you close your eyes the CEV's blast in your eyelids like a nuclear bomb went off. Then, you ask yourself how it it possible, that you feel like you're tripping.

Then, the excitement of it actually working drifts off, and you begin to enjoy a wonderful trip with just Cannabis and some nootropics.

You would be surprised, you can potentiate the Melatonin with 5-HTP, and then both will potentiate the Cannabis. Have the timing down, and right when the supplements are kicking in you smoke. This will result in some sort of synergy between the two and will remind you of the first time you smoked, how the highs used to be more insightful etc.

Nootropics are a wonderful thing.
 
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egor said:
can you say placebo??
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Try what I said above if you need to prove yourself wrong. Melatonin has some sort of psychedelic energy to it, in its own weird way, and when it's combined with a minor psychedelic like Cannabis it really brings out the true nature of the substance.

...And honestly if you feel like it's a placebo, then do some self-experimentation. Go out and by a $3.99 bottle of Melatonin, get some nice Cannabis (only $25-35 total) and follow the above instructions. If you feel like you won't be able to differentiate between a 3-4mg dosage and a placebo effect, then take 8-10mg. Just don't be too surprised in 1 1/2 - 2 hours when you go to smoke, that you are already feeling funny all over and yet you haven't even smoked yet. ;) Trust me, 8-10 mg will have you feeling nice if you're doutbful of 4mg.
 
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Perhaps it distracts MAO from breaking down whatever psychedelic you've ingested; that's the only mechanism I can see working for this.
 
butane said:
Perhaps it distracts MAO from breaking down whatever psychedelic you've ingested; that's the only mechanism I can see working for this.
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Science can't explain why you consciously die on DMT, and come back fine, body unharmed with satisfactory health. Wherein the user is pretty sure he/she just died, the entire experience itself feels almost familiar and the physical effects are as close as it gets to the real thing. The experience also replicates stories of people whom actually had REAL NEAR DEATH experiences but come out describing something that sounds like a DMT trip report.

If you were able to have a experiment going recording data of a guy actually beginning to die and someone receiving an I.V. DMT dosage, data would more in likely show similar readings, on all levels up until the point where the guy who was actually dyings heart stopped. However, up until that point, the response of the guy receiving the I.V. DMT (during) would simulate the real guy in process of making "the cross-over." The mannerisms, actions, body language, heart rate probably all would have a similar analysis between the real guy and the DMT guy. Only difference is, when the real guy's heart stops the DMT guy is on his way back.

So if Science can't explain the above, dont expect an explanation as to why Melatonin and THC work.
 
If it is placebo and using melatonin makes your trip stronger that way, it is still a good thing. It's not going to cause any harm and a good placebo can be just as good as something that really potentiates it.


If I can repeat what I did with good effects, I will not worry about whether it is just placebo. The antioxidant properties could be beneficial with MDMA. If melatonin works for you, just keep using it.
 
BiG StroOnZ said:
Try what I said above if you need to prove yourself wrong. Melatonin has some sort of psychedelic energy to it, in its own weird way, and when it's combined with a minor psychedelic like Cannabis it really brings out the true nature of the substance.

...And honestly if you feel like it's a placebo, then do some self-experimentation. Go out and by a $3.99 bottle of Melatonin, get some nice Cannabis (only $25-35 total) and follow the above instructions. If you feel like you won't be able to differentiate between a 3-4mg dosage and a placebo effect, then take 8-10mg. Just don't be too surprised in 1 1/2 - 2 hours when you go to smoke, that you are already feeling funny all over and yet you haven't even smoked yet. ;) Trust me, 8-10 mg will have you feeling nice if you're doutbful of 4mg.
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I agree with what you said, in all your posts in this thread, but IMO, and from my experiences (as well as other people's), I find it safe to say that cannabis can be very unpredictable (depending on strain, dosage, route of admin) in regards to how strongly or weakly psychedelic the effects of the herb can have on "whoever".
Ok, back to the subject of the thread; there's no reason to try to debate with me (whoever does/doesn't), as I won't be re-reading this thread. Peace.
 
I've had a few instances on the tail end of acid trips taking melatonin in an attempt to sleep.

I remember laying in bed and suddenly seeing all sorts of visuals on the ceiling. i thought it was odd. I'm unsure whether the increaed visuals were a result of the melatonin, or just a wave of visuals from the acid.

At the time I thought (and still think) it was just the acid creeping back up on me as it usually comes and goes for the last 2-4 hours of the trip.

However I don't have any solid evidence to say that it wasn't the melatonin that made me trip hard.
 
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